{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T18:22:56Z","timestamp":1790446976833,"version":"4.1.0"},"reference-count":18,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,7]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Brucellosis is a zoonotic disease that mimics many other diseases, making diagnosis difficult in pediatric patients. If the clinical signs of the disease are not well known and there is a delay in diagnosis and treatment, complicated brucellosis involving different body sites can develop. This study aimed to analyze the demographics, clinical information, laboratory test results, and imaging findings of children with brucellosis. Particular attention was paid to the involvement of organs and potential complications. Pediatric patients diagnosed with brucellosis at the Sanl\u0131urfa Training and Research Hospital in Turkey were retrospectively evaluated. In total, 101 patients diagnosed with brucellosis were included in this study. Bone-joint involvement was observed in 21 (20.7%) patients. High <jats:italic>Brucella<\/jats:italic> Coombs gel test (CT) titers (\u22651\/640) and increased erythrocyte sedimentation rate (ESR) were significant in the bone-joint brucellosis group (<jats:italic>P<\/jats:italic> = 0.022 and <jats:italic>P<\/jats:italic> = 0.0205, respectively). Fourteen (13.9%) patients had at least one organomegaly in which <jats:italic>Brucella<\/jats:italic> CT titers and C-reactive protein (CRP) levels were substantially higher than those in patients without organomegaly (<jats:italic>P<\/jats:italic> = 0.02 and <jats:italic>P<\/jats:italic> = 0.0049, respectively). Anemia, leukopenia, and thrombocytopenia were observed in 36 (35.6%), 10 (9.9%), and 4 (3.9%) patients, respectively. At least one elevation in liver function test (LFT) results was observed in 32 (31.7%) patients. High acute-phase reactants, such as ESR, CRP levels, and <jats:italic>Brucella<\/jats:italic> CT titers, may help identify complicated brucellosis. This study highlights that pediatric brucellosis can lead to cytopenia and elevated LFT results and should therefore be considered as a differential diagnosis.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0586","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T13:49:36Z","timestamp":1715694576000},"page":"305-311","source":"Crossref","is-referenced-by-count":2,"title":["Comparative Analysis of Pediatric Patients with Different Involvements of Brucellosis"],"prefix":"10.4269","volume":"111","author":[{"given":"Melis","family":"Deniz","sequence":"first","affiliation":[{"name":"Department of Pediatric Infectious Diseases, Sanl\u0131urfa Training and Research Hospital, Sanl\u0131urfa, Turkey;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hande","family":"\u015eenol","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Pamukkale University, Denizli, Turkey;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerim","family":"Parlak","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Sanl\u0131urfa Training and Research Hospital, Sanl\u0131urfa, Turkey;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feyza","family":"Kabar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Radiology, Sanl\u0131urfa Training and Research Hospital, Sanl\u0131urfa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"J Trop Pediatr","first-page":"fmab114","article-title":"Bacteremic and nonbacteremic brucellosis in children in Turkey","volume":"68","author":"\u00d6zdem","year":"2022"},{"key":"b2","series-title":"Lancet Infect Dis","first-page":"91","article-title":"The new global map of human brucellosis","volume":"6","author":"Pappas","year":"2006"},{"key":"b3","series-title":"Acta Clin Croat","first-page":"41","article-title":"Natural history of brucellosis in an endemic region in different time periods","volume":"48","author":"Bosilkovski","year":"2009"},{"key":"b4","series-title":"Turk J Pediatr","first-page":"199","article-title":"Osteoarticular involvement of brucellosis in pediatric patients: Clinical and laboratory characteristics","volume":"62","author":"\u00c7iftdo\u011fan","year":"2020"},{"key":"b5","series-title":"Pediatr Infect Dis J","first-page":"586","article-title":"Hematologic manifestations of brucellosis in children","volume":"37","author":"Justman","year":"2018"},{"key":"b6","series-title":"Cureus","first-page":"e11289","article-title":"Brucellosis in Saudi children: Presentation, complications, and treatment outcome","volume":"12","author":"Qasim","year":"2020"},{"key":"b7"},{"key":"b8","series-title":"Cureus","first-page":"e15950","article-title":"Complicated brucellosis with multisystem involvement: Two case reports","volume":"13","author":"Varikkodan","year":"2021"},{"key":"b9","series-title":"J Infect Dev Ctries","first-page":"1147","article-title":"A 10-year retrospective comparative analysis of the clinical features of brucellosis in children and adults","volume":"15","author":"Ma","year":"2021"},{"key":"b10","series-title":"J Pediatric Infect Dis Soc","first-page":"801","article-title":"Clinical practice guideline by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America: 2021 Guideline on diagnosis and management of acute hematogenous osteomyelitis in pediatrics","volume":"10","author":"Woods","year":"2021"},{"key":"b11","series-title":"Yonsei Med J","first-page":"33","article-title":"Complications of brucellosis in different age groups: A study of 283 cases in southeastern Anatolia of Turkey","volume":"44","author":"G\u00fcr","year":"2003"},{"key":"b12","series-title":"Clin Lab","first-page":"577","article-title":"Laboratory-based diagnosis of brucellosis\u2013a review of the literature. Part II: Serological tests for brucellosis","volume":"49","author":"Al Dahouk","year":"2003"},{"key":"b13","series-title":"Diagn Microbiol Infect Dis","first-page":"115003","article-title":"Risk factors for focal involvement in brucellosis","volume":"97","author":"Demirdal","year":"2020"},{"key":"b14","series-title":"Braz J Infect Dis","first-page":"520","article-title":"Unrecognized pediatric and adult family members of children with acute brucellosis","volume":"21","author":"\u00c7iftdo\u011fan","year":"2017"},{"key":"b15","series-title":"Pediatr Infect Dis J","first-page":"815","article-title":"Osteoarticular involvement in childhood brucellosis: Experience with 133 cases in an endemic region","volume":"32","author":"Bosilkovski","year":"2013"},{"key":"b16","series-title":"Vector Borne Zoonotic Dis","first-page":"545","article-title":"Pancytopenia as the initial manifestation of brucellosis in children","volume":"15","author":"Karli","year":"2015"},{"key":"b17","series-title":"Principles and Practice of Pediatric Infectious Diseases","first-page":"4562","author":"Young"},{"key":"b18","series-title":"Clin Infect Dis","first-page":"426","article-title":"Clinical findings, therapeutic approach, and outcome of brucellar vertebral osteomyelitis","volume":"46","author":"Colmenero","year":"2008"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/111\/2\/article-p305.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/111\/2\/article-p305.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/111\/2\/article-p305.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T12:39:09Z","timestamp":1723034349000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/111\/2\/article-p305.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,7]]},"references-count":18,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.23-0586","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,7]]}}}