{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:44:13Z","timestamp":1776847453275,"version":"3.51.2"},"reference-count":43,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,5]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Tick-borne disease burdens are increasing globally, impacting mostly rural and vulnerable communities. Among the most important emerging tick-borne pathogens are the <jats:italic>Rickettsia<\/jats:italic> species within the spotted fever group (SFGR) because of their genetic diversity and high lethality rate. Colombia is highly affected by SFGR despite not being reportable diseases; thus, research and clinical management are neglected. Although some departments have demonstrated high seroprevalence rates, in others, such as Boyac\u00e1 Department, seroprevalence is unknown. Rickettsioses have not been described in Boyac\u00e1 since 1943, and conversations with local physicians raised suspicions of recent undiagnosed disease compatible with rickettsiosis in some rural areas of the department, warranting epidemiological investigation. Using biobanked human and canine samples from a previous 2021 vector-borne disease study in Miraflores municipality, Boyac\u00e1, we had an opportunity to unearth SFGR\u2019s exposure in the region. Samples were evaluated using IgG indirect fluorescent assays against SFGR and complemented by survey questionnaires evaluating associated factors. Findings yielded first-time SFGR serological evidence in Boyac\u00e1 with a 26.5% seroprevalence among dogs and a 20.4% among humans. Human and dog seroprevalences were positively associated, suggesting the presence of domestic transmission. Owning a greater number of domestic animals (prevalence ratio adjusted for all measured factors [aPR], 1.52) and living near crop fields (aPR, 7.77) were associated with an increased likelihood of household seropositivity. Our findings are consistent with the literature in Colombia, uncovering a suspected region where the disease is endemic. Future studies are warranted to continue defining high-risk areas to determine public health intervention plans.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0593","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T17:47:43Z","timestamp":1712684863000},"page":"1245-1252","source":"Crossref","is-referenced-by-count":5,"title":["Antibody Seroprevalence to Spotted Fever Group Rickettsiae in Miraflores, Colombia: A Cross-Sectional Study in Humans and Dogs"],"prefix":"10.4269","volume":"110","author":[{"given":"L\u00eddia","family":"Gual-Gonzalez","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, South Carolina;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Cantillo-Barraza","sequence":"additional","affiliation":[{"name":"Grupo Biolog\u00eda y Control Enfermedades Infecciosas, Universidad de Antioquia, Medell\u00edn, Colombia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam E.","family":"Torres","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, South Carolina;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan C.","family":"Quintero-V\u00e9lez","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n Epidemiolog\u00eda, Universidad de Antioquia, Medell\u00edn, Colombia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Medina","sequence":"additional","affiliation":[{"name":"Unidad de Control de Enfermedades Transmitidas por Vectores, Secretar\u00eda de Salud de Boyac\u00e1, Tunja, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella C. W.","family":"Self","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, South Carolina;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa S.","family":"Nolan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, South Carolina;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Global Planet Change","first-page":"103","article-title":"Land use and land cover change impacts on the regional climate of non-Amazonian South America: A review","volume":"128","author":"Salazar","year":"2015"},{"key":"b2","series-title":"Geophys Res Lett","first-page":"3618","article-title":"Deforestation causes different subregional effects on the Amazon bioclimatic equilibrium","volume":"40","author":"Pires","year":"2013"},{"key":"b3","series-title":"Trends 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