{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T04:06:54Z","timestamp":1745035614951,"version":"3.40.4"},"reference-count":30,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,7]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Since the development of highly effective direct-acting antivirals, the WHO has set a goal of hepatitis C virus (HCV) elimination by 2030. Key to this strategy is increased screening and treatment. Pregnancy and the postpartum period represent a unique time when underserved populations have increased contact with the healthcare system. We propose using antenatal care to maximize case identification, treatment, and prevention. Pregnant individuals are an ideal sentinel population for HCV surveillance. Universal screening in pregnancy can provide population-level data. Once cases are identified, pregnancy presents an opportunity for intervention. Although not currently WHO approved, clinical trials are examining treatment during pregnancy. In the interim, identification of infection during pregnancy allows for optimization of the treatment cascade postpartum. Pregnancy can be used as a time for prevention. Taking advantage of patient engagement and existing infrastructure, pregnancy presents an opportunity to intervene in the fight for HCV eradication.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0629","type":"journal-article","created":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T14:16:25Z","timestamp":1703686585000},"page":"199-201","source":"Crossref","is-referenced-by-count":1,"title":["Pregnancy as an Opportunity for Hepatitis C Virus Elimination and Eradication"],"prefix":"10.4269","volume":"110","author":[{"given":"Sarah","family":"Boudova","sequence":"first","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle","family":"Tholey","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Sidney Kimmel Medical College, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan M.","family":"Fenkel","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Sidney Kimmel Medical College, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Derman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupsa C.","family":"Boelig","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Am J Perinatol","first-page":"e1","article-title":"Hepatitis C virus in pregnancy: a systematic review of the literature","volume":"38","author":"Andes","year":"2020"},{"key":"b2","series-title":"Lancet Gastroenterol Hepatol","first-page":"396","article-title":"Global change in hepatitis C virus prevalence and cascade of care between 2015 and 2020: a modelling study","volume":"7","year":"2022"},{"key":"b3","series-title":"Lancet Gastroenterol Hepatol","first-page":"169","article-title":"Global prevalence of hepatitis C virus in women of childbearing age in 2019: a modelling study","volume":"6","author":"Dugan","year":"2021"},{"key":"b4","series-title":"N Engl J Med","first-page":"1889","article-title":"Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection","volume":"370","author":"Afdhal","year":"2014"},{"key":"b5","series-title":"N Engl J Med","first-page":"2599","article-title":"Sofosbuvir and velpatasvir for HCV genotype 1, 2, 4, 5, and 6 infection","volume":"373","author":"Feld","year":"2015"},{"key":"b6","series-title":"N Engl J Med","first-page":"354","article-title":"Glecaprevir-pibrentasvir for 8 or 12 weeks in HCV genotype 1 or 3 infection","volume":"378","author":"Zeuzem","year":"2018"},{"key":"b7","series-title":"N Engl J Med","first-page":"1879","article-title":"Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis","volume":"370","author":"Kowdley","year":"2014"},{"key":"b8"},{"key":"b9","series-title":"JHEP Rep","first-page":"100227","article-title":"Where are the children in national hepatitis C policies? A global review of national strategic plans and guidelines","volume":"3","author":"Malik","year":"2021"},{"key":"b10","series-title":"Open Forum Infect Dis","first-page":"ofy043","article-title":"Risk-based hepatitis C screening in pregnancy is less reliable than universal screening: a retrospective chart review","volume":"5","author":"Boudova","year":"2018"},{"key":"b11","series-title":"J Infect","first-page":"512","article-title":"Reliability of risk-based screening for hepatitis C virus infection among pregnant women in Egypt","volume":"70","author":"El-Kamary","year":"2015"},{"key":"b12"},{"key":"b13","series-title":"Trends Parasitol","first-page":"677","article-title":"Targeting pregnant women for malaria surveillance","volume":"35","author":"Mayor","year":"2019"},{"year":"1988","series-title":"Sentinel Surveillance for HIV Infection: A Method to Monitor HIV Infection Trends in Population Groups","author":"Slutkin","key":"b14"},{"key":"b15","series-title":"Sci Rep","first-page":"11503","article-title":"Syphilis prevalence trends in adult women in 132 countries \u2013 estimations using the Spectrum Sexually Transmitted Infections model","volume":"8","author":"Korenromp","year":"2018"},{"key":"b16","series-title":"Sex Transm Dis","first-page":"21","article-title":"Developing sentinel surveillance for Chlamydia and gonorrhea using test results from routine screening during pregnancy","volume":"50","author":"Lazenby","year":"2023"},{"year":"2016","series-title":"Global Report on Access to Hepatitis C Treatment. Focus on Overcoming Barriers","key":"b17"},{"key":"b18","series-title":"Rev Esp Enferm Dig","first-page":"513","article-title":"Reflex testing. A key tool for the elimination of hepatitis C","volume":"112","author":"Herrero","year":"2020"},{"key":"b19","series-title":"Int J Drug Policy","first-page":"33","article-title":"Contact tracing for hepatitis C: the case for novel screening strategies as we strive for viral elimination","volume":"72","author":"Katzman","year":"2019"},{"key":"b20","series-title":"Am J Obstet Gynecol","first-page":"116","article-title":"Pregnancy as a \u201cgolden opportunity\u201d for patient activation and engagement","volume":"224","author":"Yee","year":"2021"},{"key":"b21","series-title":"Hepatol Commun","first-page":"1543","article-title":"Enhancing linkage to hepatitis C virus treatment following pregnancy in women identified during perinatal care","volume":"5","author":"Epstein","year":"2021"},{"key":"b22","series-title":"Lancet Gastroenterol Hepatol","first-page":"119","article-title":"Treatment of chronic hepatitis C virus infection in Rwanda with ledipasvir-sofosbuvir (SHARED): a single-arm trial","volume":"4","author":"Gupta","year":"2019"},{"key":"b23","series-title":"Clin Infect Dis","first-page":"765","article-title":"Vertical transmission of hepatitis C virus: systematic review and meta-analysis","volume":"59","author":"Benova","year":"2014"},{"key":"b24","series-title":"Pediatrics","first-page":"e20192482","article-title":"Hepatitis C testing among perinatally exposed infants","volume":"145","author":"Lopata","year":"2020"},{"key":"b25","series-title":"Hepatology","first-page":"1645","article-title":"Responsible inclusion of pregnant individuals in eradicating HCV","volume":"74","author":"Jhaveri","year":"2021"},{"key":"b26","series-title":"Subst Abuse","first-page":"11782218211046260","article-title":"Experiences and perspectives from women taking investigational therapy for hepatitis C virus during pregnancy","volume":"15","author":"Kislovskiy","year":"2021"},{"key":"b27","series-title":"Lancet Microbe","first-page":"e200","article-title":"Ledipasvir plus sofosbuvir in pregnant women with hepatitis C virus infection: a phase 1 pharmacokinetic study","volume":"1","author":"Chappell","year":"2020"},{"key":"b28","series-title":"Curr HIV\/AIDS Rep","first-page":"155","article-title":"Treatment of hepatitis C during pregnancy-weighing the risks and benefits in contrast to HIV","volume":"15","author":"Barritt","year":"2018"},{"key":"b29","series-title":"Liver Int","first-page":"416","article-title":"Hepatitis C: is eradication possible?","volume":"39","author":"Lombardi","year":"2019"},{"key":"b30","series-title":"World J Gastroenterol","first-page":"7824","article-title":"Global epidemiology of hepatitis C virus infection: an up-date of the distribution and circulation of hepatitis C virus genotypes","volume":"22","author":"Petruzziello","year":"2016"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/110\/2\/article-p199.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/110\/2\/article-p199.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/110\/2\/article-p199.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T12:51:30Z","timestamp":1744980690000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/110\/2\/article-p199.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,7]]},"references-count":30,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.23-0629","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"type":"print","value":"0002-9637"},{"type":"electronic","value":"1476-1645"}],"subject":[],"published":{"date-parts":[[2024,2,7]]}}}