{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T21:26:00Z","timestamp":1779917160469,"version":"3.53.1"},"reference-count":48,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Surveillance for genetic markers of resistance can provide valuable information on the likely efficacy of antimalarials but needs to be targeted to ensure optimal use of resources. We conducted a systematic search and review of publications in seven databases to compile resistance marker data from studies in India. The sample collection from the studies identified from this search was conducted between 1994 and 2020, and these studies were published between 1994 and 2022. In all, <jats:italic>Plasmodium falciparum<\/jats:italic> Kelch13 (PfK13), <jats:italic>P. falciparum<\/jats:italic> dihydropteroate synthase, and <jats:italic>P. falciparum<\/jats:italic> dihydrofolate reductase (PfDHPS) genotype data from 2,953, 4,148, and 4,222 blood samples from patients with laboratory-confirmed malaria, respectively, were extracted from these publications and uploaded onto the WorldWide Antimalarial Resistance Network molecular surveyors. These data were fed into hierarchical geostatistical models to produce maps with a predicted prevalence of the PfK13 and PfDHPS markers, and of the associated uncertainty. Zones with a predicted PfDHPS 540E prevalence of &gt;15% were identified in central, eastern, and northeastern India. The predicted prevalence of PfK13 mutants was nonzero at only a few locations, but were within or adjacent to the zones with &gt;15% prevalence of PfDHPS 540E. There may be a greater probability of artesunate\u2013sulfadoxine\u2013pyrimethamine failures in these regions, but these predictions need confirmation. This work can be applied in India and elsewhere to help identify the treatments most likely to be effective for malaria elimination.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0631","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T15:18:08Z","timestamp":1712071088000},"page":"910-920","source":"Crossref","is-referenced-by-count":7,"title":["Systematic Review and Geospatial Modeling of Molecular Markers of Resistance to Artemisinins and Sulfadoxine\u2013Pyrimethamine in Plasmodium falciparum in India"],"prefix":"10.4269","volume":"110","author":[{"given":"Minu","family":"Nain","sequence":"first","affiliation":[{"name":"ICMR-National Institute of Malaria Research, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehul","family":"Dhorda","sequence":"additional","affiliation":[{"name":"WorldWide Antimalarial Resistance Network, Oxford, United Kingdom;"},{"name":"Infectious Diseases Data Observatory, Oxford, United Kingdom;"},{"name":"Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand;"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Flegg","sequence":"additional","affiliation":[{"name":"School of Mathematics and Statistics, University of Melbourne, Parkville, Victoria, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apoorv","family":"Gupta","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Malaria Research, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucinda E.","family":"Harrison","sequence":"additional","affiliation":[{"name":"School of Mathematics and Statistics, University of Melbourne, Parkville, Victoria, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sauman","family":"Singh-Phulgenda","sequence":"additional","affiliation":[{"name":"Infectious Diseases Data Observatory, Oxford, United Kingdom;"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina D.","family":"Otienoburu","sequence":"additional","affiliation":[{"name":"WorldWide Antimalarial Resistance Network, Oxford, United Kingdom;"},{"name":"Infectious Diseases Data Observatory, Oxford, United Kingdom;"},{"name":"College of STEM, Johnson C. Smith University, Charlotte, North Carolina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Harriss","sequence":"additional","affiliation":[{"name":"The Knowledge Centre, Bodleian Health Care Libraries, University of Oxford, Oxford, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen K.","family":"Bharti","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Malaria Research, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beauty","family":"Behera","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Malaria Research, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manju","family":"Rahi","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Malaria Research, New Delhi, India;"},{"name":"Indian Council of Medical Research, New Delhi, India;"},{"name":"Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe J.","family":"Guerin","sequence":"additional","affiliation":[{"name":"WorldWide Antimalarial Resistance Network, Oxford, United Kingdom;"},{"name":"Infectious Diseases Data Observatory, Oxford, United Kingdom;"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Sharma","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Malaria Research, New Delhi, India;"},{"name":"Molecular Medicine, International Centre for Genetic Engineering and Biotechnology, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Global Technical Strategy for Malaria 2016\u20132030: 2021 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asymptomatic malaria in a tribal population in eastern India","volume":"51","author":"Ganguly","year":"2013"},{"key":"b47","series-title":"Sci Rep","first-page":"13704","article-title":"Characterization of drug resistance and genetic diversity of Plasmodium falciparum parasites from Tripura, Northeast India","volume":"9","author":"Patgiri","year":"2019"},{"key":"b48","series-title":"Malar J","first-page":"75","article-title":"Tools for surveillance of anti-malarial drug resistance: An assessment of the current landscape","volume":"17","author":"Nsanzabana","year":"2018"}],"container-title":["The American Journal of Tropical Medicine and 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