{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T13:10:41Z","timestamp":1781788241923,"version":"3.54.5"},"reference-count":36,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,4]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>An assessment of the treatment outcomes of single-dose liposomal amphotericin B, implemented in 2010, had not been conducted until this study. This prospective cross-sectional study encompassed 527 cases, comprising 470 (89%) cases of visceral leishmaniasis (VL) and 57 (11%) cases of post\u2013kala-azar dermal leishmaniasis (PKDL). The male proportion was higher (55% for VL), and the mean (\u00b1SD) age was 39.2 (\u00b133.9) years. Among VL cases (426) treated with single-dose liposomal amphotericin B, 402 cases were cured at the 6-month follow-up, resulting in a cure rate of 95%, whereas fewer than 1% (0.9%) experienced unsuccessful outcomes and 4.1% faced relapse. A statistically highly significant difference in treatment outcomes (successful versus unsuccessful) was observed between males and females (<jats:italic>P<\/jats:italic> = 0.0005). Males had higher odds of successful outcomes compared with females, with an odds ratio of 5.03 (95% CI: 1.84\u201313.74). Those aged \u226423\u2009years had higher odds of successful outcomes than unsuccessful outcomes, with an odds ratio of 6.82 (95% CI: 2.29\u201320.33). Patients with PKDL had a mean (\u00b1SD) age of 28.5 (\u00b110.6) years, with 63% being male. Among the 57 PKDL cases, 21 (37%) had been treated with single-dose liposomal amphotericin B, whereas others had received alternative drugs. The median duration of PKDL development for single-dose liposomal amphotericin B was significantly shorter (14.5 months), with a statistically significant difference (<jats:italic>P<\/jats:italic> &lt;0.001) compared with other drugs. The current treatment strategy necessitates continuous close monitoring and reviews to ensure consistent and improved outcomes.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0640","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T14:54:42Z","timestamp":1728399282000},"page":"1198-1205","source":"Crossref","is-referenced-by-count":1,"title":["Treatment Outcomes of Single-Dose Liposomal Amphotericin B\u2013Treated Visceral Leishmaniasis Patients and Factors Affecting Outcome in Bihar, India"],"prefix":"10.4269","volume":"111","author":[{"given":"Niyamat Ali","family":"Siddiqui","sequence":"first","affiliation":[{"name":"Indian Council of Medical Research (ICMR)-Rajendra Memorial Research Institute of Medical Sciences (RMRIMS), Patna, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd. Zahid","family":"Ansari","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research (ICMR)-Rajendra Memorial Research Institute of Medical Sciences (RMRIMS), Patna, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay Kumar","family":"Sinha","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research (ICMR)-Rajendra Memorial Research Institute of Medical Sciences (RMRIMS), Patna, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biplab","family":"Pal","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Pharmaceutical Science, Lovely Professional University, Phagwara, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Sciences, RK University, Rajkot, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhankar Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research (ICMR)-Rajendra Memorial Research Institute of Medical Sciences (RMRIMS), Patna, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roshan Kamal","family":"Topno","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research (ICMR)-Rajendra Memorial Research Institute of Medical Sciences (RMRIMS), Patna, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidya Nand","family":"Rabi Das","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research (ICMR)-Rajendra Memorial Research Institute of Medical Sciences (RMRIMS), Patna, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna","family":"Pandey","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research 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post-kala-azar dermal leishmaniasis (PKDL) and clinico-epidemiological profile in highly endemic areas of Bihar","volume":"113","author":"Rabi Das","year":"2019"},{"key":"b6","series-title":"Clin Microbiol Rev","first-page":"334","article-title":"The relationship between leishmaniasis and AIDS: The second 10 years","volume":"21","author":"Alvar","year":"2008"},{"key":"b7","series-title":"Trop Med Int Health","first-page":"848","article-title":"Clinical characteristics and treatment outcome of patients with visceral leishmaniasis and HIV co-infection in northwest Ethiopia","volume":"15","author":"Hurissa","year":"2010"},{"key":"b8","series-title":"Sci Rep","first-page":"3129","article-title":"Effects of high CD4 cell counts on death and attrition among HIV patients receiving antiretroviral treatment: An observational cohort study","volume":"7","author":"Tang","year":"2017"},{"key":"b9","series-title":"PLoS Negl Trop Dis","first-page":"e3053","article-title":"Visceral leishmaniasis and HIV co-infection in Bihar, India: Long-term effectiveness and treatment outcomes with liposomal amphotericin B (AmBisome)","volume":"8","author":"Burza","year":"2014"},{"key":"b10","series-title":"Accelerated Plan for Kala-Azar Elimination: Directorate, National Vector Borne Diseases Control Programme","year":"2017"},{"key":"b11"},{"key":"b12","series-title":"BMC Public Health","first-page":"62","article-title":"DOTS improves treatment outcomes and service coverage for tuberculosis in South Ethiopia: A retrospective trend analysis","volume":"5","author":"Shargie","year":"2005"},{"key":"b13","series-title":"BMC Public Health","first-page":"537","article-title":"Treatment outcome of smear positive pulmonary tuberculosis patients in Tigray Region, northern Ethiopia","volume":"12","author":"Berhe","year":"2012"},{"key":"b14","series-title":"Int J Tuberc Lung Dis","first-page":"1166","article-title":"Ten-year experiences of the tuberculosis control programme in the southern region of Ethiopia","volume":"10","author":"Yassin","year":"2006"},{"key":"b15","series-title":"Tuberc Res Treat","first-page":"726193","article-title":"Treatment outcome of tuberculosis patients at Enfraz Health Center, northwest Ethiopia: A five-year retrospective study","volume":"2014","author":"Endris","year":"2014"},{"key":"b16","series-title":"PLoS Negl Trop Dis","first-page":"e2611","article-title":"Post kala-azar dermal leishmaniasis following treatment with 20 mg\/kg liposomal amphotericin B (AmBisome) for primary visceral leishmaniasis in Bihar, India","volume":"8","author":"Burza","year":"2014"},{"key":"b17"},{"key":"b18","series-title":"Pan Afr Med J","first-page":"247","article-title":"Risk factors for unsuccessful tuberculosis treatment outcome (failure, default and death) in public health institutions, eastern Ethiopia","volume":"20","author":"Amante","year":"2015"},{"key":"b19","series-title":"Bull Int Union Tuberc","first-page":"70","article-title":"The fate of cases of pulmonary tuberculosis under various treatment programmes","volume":"53","author":"Grzybowski","year":"1978"},{"key":"b20","series-title":"BMC Res Notes","first-page":"666","article-title":"TB\/HIV co-infections and associated factors among patients on directly observed treatment short course in northeastern Ethiopia: A 4 years retrospective study","volume":"8","author":"Mekonnen","year":"2015"},{"key":"b21","series-title":"BMC Res Notes","first-page":"503","article-title":"Adherence to anti-tuberculosis treatment and treatment outcomes among tuberculosis patients in Alamata District, northeast Ethiopia","volume":"8","author":"Tesfahuneygn","year":"2015"},{"key":"b22","series-title":"Int J Tuberc Lung Dis","first-page":"973","article-title":"Factors associated with poor tuberculosis treatment outcome in the southern region of Ethiopia","volume":"14","author":"Mu\u00f1oz-Sellart","year":"2010"},{"key":"b23","series-title":"Epidemiol Health","first-page":"e2017001","article-title":"Visceral leishmaniasis treatment outcome and its determinants in northwest Ethiopia","volume":"39","author":"Welay","year":"2017"},{"key":"b24","series-title":"J Infect Dev Ctries","first-page":"42S","article-title":"Clinical features and treatment outcomes of visceral leishmaniasis patients admitted to three centres in Oromia, Ethiopia","volume":"14","author":"Tekalign","year":"2020"},{"key":"b25","series-title":"J Infect","first-page":"60","article-title":"Visceral leishmaniasis (kala-azar): The Bihar (India) perspective","volume":"53","author":"Sinha","year":"2006"},{"key":"b26","series-title":"Am J Trop Med Hyg","first-page":"778","article-title":"Indian visceral leishmaniasis prevalence and associated risk factors in the Saran District of Bihar, India, from 2009 to July of 2011","volume":"88","author":"Perry","year":"2013"},{"key":"b27","series-title":"PloS Negl Trop Dis","first-page":"e0005150","article-title":"Epidemiologic 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Dis","first-page":"548","article-title":"Safety and efficacy of liposomal amphotericin B for treatment of complicated visceral leishmaniasis in patients without HIV, north-west Ethiopia","volume":"16","author":"Tamiru","year":"2016"},{"key":"b32","series-title":"Trop Med Int Health","first-page":"146","article-title":"Liposomal amphotericin B for complicated visceral leishmaniasis (kala-azar) in eastern Sudan: How effective is treatment for this neglected disease?","volume":"19","author":"Salih","year":"2014"},{"key":"b33","series-title":"PLo S Negl Trop Dis","first-page":"e0007726","article-title":"Field effectiveness of new visceral leishmaniasis regimens after 1 year following treatment within public health facilities in Bihar, India","volume":"13","author":"Goyal","year":"2019"},{"key":"b34","series-title":"PLoS Negl Trop Dis","first-page":"e0009598","article-title":"Improved kala-azar case management through implementation of health facility-based sentinel sites surveillance 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