{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:31:11Z","timestamp":1791952271484,"version":"4.3.4"},"reference-count":17,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Infection with <jats:italic>Strongyloides stercoralis<\/jats:italic> is often asymptomatic but can be life-threatening in immunocompromised patients, which can be prevented by ivermectin (IVM) treatment. The efficacy of IVM has been reported to have lessened over time in some regions as a consequence of prolonged use and mass treatment campaigns. Ivermectin has been used in Thailand for more than a decade; therefore, we investigated the efficacy of a single dose (200\u2009\u00b5g\/kg) of IVM against in asymptomatic strongyloidiasis in northeastern Thailand. Fecal samples were collected before and 2\u2009weeks after treatment and were analyzed for the presence of <jats:italic>Strongyloides<\/jats:italic> using a modified agar plate culture and the formalin-ethyl acetate concentration technique. Our results showed that single-dose IVM treatment successfully eliminated <jats:italic>S. stercoralis<\/jats:italic> infection in asymptomatic individuals in the endemic area with a 100% cure rate, indicating the high efficacy of IVM treatment in strongyloidiasis in northeast Thailand.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0645","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T15:17:40Z","timestamp":1712071060000},"page":"951-952","source":"Crossref","is-referenced-by-count":6,"title":["High Efficacy of Ivermectin for Strongyloidiasis Treatment"],"prefix":"10.4269","volume":"110","author":[{"given":"Chatchawan","family":"Sengthong","sequence":"first","affiliation":[{"name":"The Office of Disease Prevention and Control 7, Khon Kaen, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somchai","family":"Pinlaor","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;"},{"name":"Chronic Kidney Disease Prevention in The Northeast of Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manachai","family":"Yingklang","sequence":"additional","affiliation":[{"name":"Department of Fundamentals of Public Health, Faculty of Public Health, Burapha University, Chonburi, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ornuma","family":"Haonon","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Immunology Research Unit, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanakan","family":"Jantawong","sequence":"additional","affiliation":[{"name":"Department of Medical Technology, Faculty of Allied Health Science, Nakhonratchasima College, Nakhon Ratchasima, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Porntip","family":"Pinlaor","sequence":"additional","affiliation":[{"name":"Chronic Kidney Disease Prevention in The Northeast of Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;"},{"name":"Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paiboon","family":"Sithithaworn","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuttanan","family":"Hongsrichan","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;"},{"name":"Chronic Kidney Disease Prevention in The Northeast of Thailand, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Pathogens","first-page":"468","article-title":"The global prevalence of Strongyloides stercoralis infection","volume":"9","author":"Buonfrate","year":"2020"},{"key":"b2","series-title":"BMC Public Health","first-page":"940","article-title":"Current high prevalences of Strongyloides stercoralis and Opisthorchis viverrini infections in rural communities in northeast Thailand and associated risk factors","volume":"18","author":"Laoraksawong","year":"2018"},{"key":"b3","series-title":"Res Rep Trop Med","first-page":"55","article-title":"Human strongyloidiasis: Identifying knowledge gaps, with emphasis on environmental control","volume":"5","author":"Taylor","year":"2014"},{"key":"b4","series-title":"J Clin Gastroenterol","first-page":"203","article-title":"Intestinal strongyloidiasis: Recognition, management, and 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Res","first-page":"1409","article-title":"An optimized agar plate culture improves diagnostic efficiency for Strongyloides stercoralis infection in an endemic community","volume":"119","author":"Sengthong","year":"2020"},{"key":"b10","series-title":"Southeast Asian J Trop Med Public Health","first-page":"442","article-title":"Prevalence of Strongyloides in northern Thailand and treatment with ivermectin vs albendazole","volume":"36","author":"Nontasut","year":"2005"},{"key":"b11","series-title":"Afr J Biotechnol","first-page":"465","article-title":"Comparison of ivermectin and thiabendazole in the treatment of uncomplicated human Strongyloides stercoralis infection","volume":"2","author":"Adenusi","year":"2003"},{"key":"b12","series-title":"Southeast Asian J Trop Med Public Health","first-page":"147","article-title":"Comparative studies on the efficacy of three anthelminthics on treatment of human strongyloidiasis in Okinawa, Japan","volume":"31","author":"Toma","year":"2000"},{"key":"b13","series-title":"Parasitology","first-page":"263","article-title":"Human infection with Strongyloides stercoralis and other related Strongyloides species","volume":"144","author":"Nutman","year":"2017"},{"key":"b14","series-title":"J Infect Chemother","first-page":"94","article-title":"Efficacy of ivermectin for chronic strongyloidiasis: Two single doses given 2 weeks apart","volume":"8","author":"Zaha","year":"2002"},{"key":"b15","series-title":"Lancet Infect Dis","first-page":"1181","article-title":"Multiple-dose versus single-dose ivermectin for Strongyloides stercoralis infection (Strong Treat 1 to 4): A multicentre, open-label, phase 3, randomised controlled superiority trial","volume":"19","author":"Buonfrate","year":"2019"},{"key":"b16","series-title":"Am J Trop Med Hyg","first-page":"967","article-title":"Fluctuations of larval excretion in Strongyloides stercoralis infection","volume":"60","author":"Uparanukraw","year":"1999"},{"key":"b17","series-title":"J Clin Microbiol","first-page":"4216","article-title":"Albendazole stimulates the excretion of Strongyloides stercoralis larvae in stool specimens and enhances sensitivity for diagnosis of strongyloidiasis","volume":"48","author":"Anamnart","year":"2010"}],"container-title":["The American Journal of Tropical Medicine and 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