{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:35:09Z","timestamp":1791041709028,"version":"4.1.0"},"reference-count":35,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,6]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>\n                    The Malayan pit viper (MPV:\n                    <jats:italic>Calloselasma rhodostoma<\/jats:italic>\n                    ) is a medically important venomous snake causing numerous envenomations in Thailand. Administration of specific snake antivenom is the only effective treatment for MPV-envenomed patients. However, inappropriate administration or misuse of snake antivenom is problematic in some remote areas of tropical countries where the snakebite envenoming rate is notable. Currently, the indications for administration of MPV antivenom are focused mainly on hematological factors. These include 1) venous clotting time &gt; 20\u2009min, 2) unclotted 20-minute whole-blood clotting time, 3) international normalized ratio &gt; 1.2, 4) platelet count &lt; 50 \u00d7 10\n                    <jats:sup>3<\/jats:sup>\n                    \/\u03bcL, 5) systemic bleeding, and 6) impending compartment syndrome. We aimed to determine the association between laboratory data and antivenom administration in MPV-envenomed patients. A retrospective study of data from 2016 to 2021 in Narathiwat Province, the southernmost province in Thailand, was conducted. A total of 838 MPV-bitten patients were included in this study. Local effects and systemic effects were observed in 58.8% and 27.7% of patients, respectively. Coagulopathies, which range from abnormal blood clotting to systemic bleeding, represented the majority of systemic effects. Acute kidney injury developed in 2.5% of patients. In this study, 57.3% of patients were considered appropriate antivenom recipients. Interestingly, the present study revealed that local bleeding and mild to moderate thrombocytopenia became the independent factors for inappropriate use of MPV antivenom. Reeducation and supervision regarding the rational use of snake antivenom are needed to minimize the misuse of antivenom.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.23-0657","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T08:46:47Z","timestamp":1706690807000},"page":"609-617","source":"Crossref","is-referenced-by-count":11,"title":["Clinical Laboratory Investigations and Antivenom Administration after Malayan Pit Viper (Calloselasma rhodostoma) Envenoming: A Retrospective Study from Southernmost Thailand"],"prefix":"10.4269","volume":"110","author":[{"given":"Musleeha","family":"Chesor","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Princess of Naradhiwas University, Narathiwat, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janeyuth","family":"Chaisakul","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Phramongkutklao College of Medicine, Bangkok, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panuwat","family":"Promsorn","sequence":"additional","affiliation":[{"name":"Galyani Vadhana Karun Hospital, Faculty of Medicine, Princess of Naradhiwas University, Narathiwat, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wittawat","family":"Chantkran","sequence":"additional","affiliation":[{"name":"Department of Pathology, Phramongkutklao College of Medicine, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","year":"2021"},{"key":"b2","year":"2016"},{"key":"b3","series-title":"Ther Clin Risk Manag","first-page":"1257","article-title":"Malayan pit viper envenomation and treatment in Thailand","volume":"17","author":"Tangtrongchitr","year":"2021"},{"key":"b4","series-title":"Mil Med","first-page":"342","article-title":"A study of 225 Malayan pit viper bites in Thailand","volume":"170","author":"Wongtongkam","year":"2005"},{"key":"b5","series-title":"J Toxicol Toxin Rev","first-page":"1","article-title":"The toxinology of Calloselasma rhodostoma (Malayan pit viper) venom","volume":"15","author":"Tan","year":"1996"},{"key":"b6","series-title":"Trop Med Infect Dis","first-page":"346","article-title":"Clinical profile and pharmacological management of snakebites in community care units: a retrospective study using two military hospital databases in South Thailand","volume":"8","author":"Lertsakulbunlue","year":"2023"},{"key":"b7","series-title":"Asian Biomed","first-page":"795","article-title":"Review article. 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