{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:09:43Z","timestamp":1781050183264,"version":"3.54.1"},"reference-count":38,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","license":[{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,3]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>This study was undertaken to understand the perspective of adolescents in endemic communities of India regarding soil-transmitted helminth (STH) infections and community-wide mass drug administration (cMDA). A multicountry community-based cluster-randomized trial, the Deworm3 trial, tested the feasibility of interrupting STH transmission with cMDA, where all individuals aged 1\u201399 are treated empirically with albendazole. Using a guideline based on the Consolidated Framework for Implementation Research, eight focus group discussions were conducted among 57 adolescents from the trial site in India and analyzed on ATLAS.ti 8.0 software using an a priori thematic codebook. Adolescents believed that adults could be a source of STH infection because they were not routinely dewormed like the children through the national deworming program. Perceived benefits of cMDA for all were better health and increased work efficiency. Perceived barriers to adults\u2019 participation in cMDA was their mistrust about the program, fear of side effects, perceived low risk of infection, and absence during drug distribution. To encourage adult participation in cMDAs, adolescents suggested community outreach activities, engaging village influencers and health workers, and tailoring drug distribution to when adults would be available. Adolescents were confident in their ability to be change agents within their households for treatment compliance. Adolescents provided insights into potential barriers and solutions to improve adult participation in cMDA, identified best practices of cMDA delivery, and suggested that they have unique roles as change agents to increase their household participation in cMDA.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0676","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T16:31:46Z","timestamp":1710261106000},"page":"681-686","source":"Crossref","is-referenced-by-count":4,"title":["Adolescents\u2019 Perspective Regarding a Community-Wide Mass Drug Administration Program for Soil-Transmitted Helminths in India"],"prefix":"10.4269","volume":"110","author":[{"given":"Kumudha","family":"Aruldas","sequence":"first","affiliation":[{"name":"The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jabaselvi","family":"Johnson","sequence":"additional","affiliation":[{"name":"The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malvika","family":"Saxena","sequence":"additional","affiliation":[{"name":"The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelin","family":"Titus","sequence":"additional","affiliation":[{"name":"The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Roll","sequence":"additional","affiliation":[{"name":"Department of Global Health, University of Washington, Seattle, Washington;"},{"name":"The DeWorm3 Project, University of Washington, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan Michael","family":"Ramesh","sequence":"additional","affiliation":[{"name":"The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judd L.","family":"Walson","sequence":"additional","affiliation":[{"name":"The DeWorm3 Project, University of Washington, Seattle, Washington;"},{"name":"Departments of Global Health, Medicine, Pediatrics and Epidemiology, University of Washington, Seattle, Washington;"},{"name":"Department of International Health, Johns Hopkins University, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna Rubin","family":"Means","sequence":"additional","affiliation":[{"name":"Department of Global Health, University of Washington, Seattle, Washington;"},{"name":"The DeWorm3 Project, University of Washington, Seattle, Washington;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sitara Swarna Rao","family":"Ajjampur","sequence":"additional","affiliation":[{"name":"The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","year":"2017"},{"key":"b2","series-title":"Parasit Vectors","first-page":"37","article-title":"Global numbers of infection and disease burden of soil transmitted helminth infections in 2010","volume":"7","author":"Pullan","year":"2014"},{"key":"b3","series-title":"PLoS Negl Trop Dis","first-page":"e0007580","article-title":"Risk profiling of soil-transmitted helminth infection and estimated number of infected people in South Asia: A systematic review and Bayesian geostatistical analysis","volume":"13","author":"Lai","year":"2019"},{"key":"b4","series-title":"BMC Public Health","first-page":"201","article-title":"Prevalence and distribution of soil-transmitted helminth infections in India","volume":"17","author":"Salam","year":"2017"},{"key":"b5","year":"2015"},{"key":"b6","year":"2012"},{"key":"b7","series-title":"PLoS Negl Trop Dis","first-page":"e1621","article-title":"Soil-transmitted helminth reinfection after drug treatment: A systematic review and meta-analysis","volume":"6","author":"Jia","year":"2012"},{"key":"b8","series-title":"PLoS Negl Trop Dis","first-page":"e2027","article-title":"How effective is school-based deworming for the community-wide control of soil-transmitted helminths?","volume":"7","author":"Anderson","year":"2013"},{"key":"b9","series-title":"Parasit Vectors","first-page":"551","article-title":"What impact will the achievement of the current World Health Organisation targets for anthelmintic treatment coverage in children have on the intensity of soil transmitted helminth infections?","volume":"8","author":"Truscott","year":"2015"},{"key":"b10","series-title":"Lancet Infect Dis","first-page":"941","article-title":"Global feasibility assessment of interrupting the transmission of soil-transmitted helminths: A statistical modelling study","volume":"15","author":"Brooker","year":"2015"},{"key":"b11","series-title":"Lancet","first-page":"2039","article-title":"Effects, equity, and cost of school-based and community-wide treatment strategies for soil-transmitted helminths in Kenya: A cluster-randomised controlled trial","volume":"393","author":"Pullan","year":"2019"},{"key":"b12","series-title":"Lancet","first-page":"287","article-title":"Differential effect of mass deworming and targeted deworming for soil-transmitted helminth control in children: A systematic review and meta-analysis","volume":"389","author":"Clarke","year":"2017"},{"key":"b13","series-title":"PLoS Negl Trop Dis","first-page":"e0008771","article-title":"Baseline patterns of infection in regions of Benin, Malawi and India seeking to interrupt transmission of soil transmitted helminths (STH) in the DeWorm3 trial","volume":"14","year":"2020"},{"key":"b14","series-title":"PLoS Negl Trop Dis","first-page":"e0006166","article-title":"Assessing the feasibility of interrupting the transmission of soil-transmitted helminths through mass drug administration: The DeWorm3 cluster randomized trial protocol","volume":"12","author":"\u00c1sbj\u00f6rnsd\u00f3ttir","year":"2018"},{"key":"b15","series-title":"PLoS Negl Trop Dis","first-page":"e0005988","article-title":"Evaluating the sustainability, scalability, and replicability of an STH transmission interruption intervention: The DeWorm3 implementation science protocol","volume":"12","author":"Means","year":"2018"},{"key":"b16","series-title":"BMC Health Serv Res","first-page":"792","article-title":"Defining optimal implementation packages for delivering community-wide mass drug administration for soil-transmitted helminths with high coverage","volume":"22","author":"Gwayi-Chore","year":"2022"},{"key":"b17","series-title":"Implement Sci Commun","first-page":"80","article-title":"Structural readiness to implement community-wide mass drug administration programs for soil-transmitted helminth elimination: Results from a three-country hybrid study","volume":"2","author":"Means","year":"2021"},{"key":"b18","series-title":"Glob Health Res Policy","first-page":"47","article-title":"Policy stakeholder perspectives on barriers and facilitators to launching a community-wide mass drug administration program for soil-transmitted helminths","volume":"7","author":"Roll","year":"2022"},{"key":"b19","series-title":"PLoS Negl Trop Dis","first-page":"e0008829","article-title":"Gender differences in the perceived need for community-wide deworming: Formative qualitative research from the DeWorm3 study, India","volume":"14","author":"Aruldas","year":"2020"},{"key":"b20","series-title":"BMJ Open","first-page":"e061682","article-title":"It depends on how you tell: A qualitative diagnostic analysis of the implementation climate for community-wide mass drug administration for soil-transmitted helminth","volume":"12","author":"Avokpaho","year":"2022"},{"key":"b21","series-title":"PLoS Negl Trop Dis","first-page":"e0009338","article-title":"Epidemiology of soil transmitted helminths and risk analysis of hookworm infections in the community: Results from the DeWorm3 Trial in southern India","volume":"15","author":"Ajjampur","year":"2021"},{"key":"b22","series-title":"Implement Sci","first-page":"50","article-title":"Fostering implementation of health services research findings into practice: A consolidated framework for advancing implementation science","volume":"4","author":"Damschroder","year":"2009"},{"key":"b23","series-title":"PLoS Negl Trop Dis","first-page":"e0010984","article-title":"Soil-transmitted helminth surveillance in Benin: A mixed-methods analysis of factors influencing non-participation in longitudinal surveillance activities","volume":"17","author":"Murphy","year":"2023"},{"key":"b24","series-title":"Trop Med Int Health","first-page":"702","article-title":"Coverage, compliance and some operational issues of mass drug administration during the programme to eliminate lymphatic filariasis in Orissa, India","volume":"9","author":"Babu","year":"2024"},{"key":"b25","series-title":"PLoS One","first-page":"e109316","article-title":"Factors influencing drug uptake during mass drug administration for control of lymphatic filariasis in rural and urban Tanzania","volume":"9","author":"Kisoka","year":"2014"},{"key":"b26","series-title":"Infect Dis Poverty","first-page":"31","article-title":"Mass drug administration for lymphatic filariasis elimination in a coastal state of India: A study on barriers to coverage and compliance","volume":"3","author":"Hussain","year":"2014"},{"key":"b27","series-title":"PLoS Negl Trop Dis","first-page":"e0011176","article-title":"Evaluation of opportunities to implement community-wide mass drug administration for interrupting transmission of soil-transmitted helminths infections in India","volume":"17","author":"Aruldas","year":"2023"},{"key":"b28","series-title":"Filaria J","first-page":"11","article-title":"Social mobilisation, drug coverage and compliance and adverse reactions in a mass drug administration (MDA) programme for the elimination of lymphatic filariasis in Sri Lanka","volume":"6","author":"Weerasooriya","year":"2007"},{"key":"b29","series-title":"PLoS One","first-page":"e83413","article-title":"Increasing coverage in mass drug administration for lymphatic filariasis elimination in an urban setting: A study of Malindi Town, Kenya","volume":"9","author":"Njomo","year":"2014"},{"key":"b30","series-title":"PLoS Negl Trop Dis","first-page":"e2447","article-title":"A review of factors that influence individual compliance with mass drug administration for elimination of lymphatic filariasis","volume":"7","author":"Krentel","year":"2013"},{"key":"b31","series-title":"Am J Trop Med Hyg","first-page":"125","article-title":"Review of mass drug administration for malaria and its operational challenges","volume":"93","author":"Newby","year":"2015"},{"key":"b32","series-title":"Health Educ Res","first-page":"521","article-title":"\u201cA child is also a teacher\u201d: Exploring the potential for children as change agents in the context of a school-based WASH intervention in rural Eastern Zambia","volume":"31","author":"Bresee","year":"2016"},{"key":"b33","series-title":"BMC Public Health","first-page":"893","article-title":"The effect of youths as change agents on cardiovascular disease risk factors among adult neighbours: A cluster randomised controlled trial in Sri Lanka","volume":"19","author":"Chandraratne","year":"2019"},{"key":"b34","series-title":"Int J Behav Nutr Phys Act","first-page":"45","article-title":"School-based intervention to enable school children to act as change agents on weight, physical activity and diet of their mothers: A cluster randomized controlled trial","volume":"13","author":"Gunawardena","year":"2016"},{"key":"b35","series-title":"J Public Health Manag Pract","first-page":"S79","article-title":"Engaging youth in participatory research and evaluation","volume":"12","author":"Powers","year":"2006"},{"key":"b36","author":"Sabo","year":"2001"},{"key":"b37","year":"2018"},{"key":"b38","year":"2014"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/110\/4\/article-p681.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/110\/4\/article-p681.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/110\/4\/article-p681.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T13:10:40Z","timestamp":1712149840000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/110\/4\/article-p681.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,3]]},"references-count":38,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.23-0676","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,3]]}}}