{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:28:45Z","timestamp":1789424925906,"version":"build-2803163510"},"reference-count":19,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"ABSTRACT.<\/jats:title>\n \n Weissella<\/jats:italic>\n species are mistaken for\n Lactobacillus<\/jats:italic>\n or\n Leuconostoc<\/jats:italic>\n because of their Gram-staining property and resistance to vancomycin. In this study, we aimed to evaluate the demographic pattern, presenting symptoms, risk factors, associated pathologies, and clinical outcomes in patients with\n Weissella<\/jats:italic>\n infection. We also analyzed the antibiotic susceptibility pattern of the\n Weissella<\/jats:italic>\n species isolated. This retrospective observational study was done from January 2021 to August 2023 in a tertiary care referral center in Uttar Pradesh. All\n Weissella<\/jats:italic>\n species isolated from blood cultures or cerebrospinal fluid (CSF) samples during this period were included in the study. Twenty-four\u2013hour growth from a positive blood culture or CSF sample was identified by matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry. Demographic and clinical details of the patients were extracted from the hospital information system. Kirby-Bauer disk diffusion was used for antibiotic susceptibility testing. During the 3-year study, 13 isolates of\n Weissella<\/jats:italic>\n species were identified in our laboratory. Among the patients, male predominance was seen. The age range of the patients was 5\u201353 years. The samples were blood samples (\n n<\/jats:italic>\n = 11) and CSF samples (\n n<\/jats:italic>\n = 2). Of these isolates, 12 (92.3%) were identified as\n Weissella confusa<\/jats:italic>\n and 1 (7.69%) was identified as\n Weissella viridescens<\/jats:italic>\n . Common risk factors were anemia, prolonged hospital stay, indwelling catheter, chemotherapy, and chronic kidney disease. All the isolates in this study were sensitive to amikacin, daptomycin, amoxicillin-clavulanate, minocycline, and linezolid. Death was attributed to\n Weissella<\/jats:italic>\n infection in three patients.\n Weissella<\/jats:italic>\n species are opportunistic organisms that need to be identified quickly and precisely to guarantee the right course of treatment.\n <\/jats:p>","DOI":"10.4269\/ajtmh.23-0713","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T11:05:49Z","timestamp":1714561549000},"page":"1006-1009","source":"Crossref","is-referenced-by-count":5,"title":["Characterization of Weissella Species during a 3-Year Observational Study \u2013 An Emerging Threat"],"prefix":"10.4269","volume":"110","author":[{"given":"Ashima","family":"Jamwal","sequence":"first","affiliation":[{"name":"Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerlin","family":"Varghese","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepika","family":"Sarawat","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhi","family":"Tejan","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangram Singh","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinmoy","family":"Sahu","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"J Infect","first-page":"e149","article-title":"Severe infective endocarditis of native valves caused by Weissella confusa detected incidentally on echocardiography","volume":"54","author":"Shin","year":"2007"},{"key":"b2","series-title":"Ann Lab Med","first-page":"459","article-title":"Weissella confusa bacteremia in an immune-competent patient with underlying intramural hematomas of the aorta","volume":"33","author":"Lee","year":"2013"},{"key":"b3","series-title":"Front Microbiol","first-page":"155","article-title":"The genus Weissella: Taxonomy, ecology and biotechnological potential","volume":"6","author":"Fusco","year":"2015"},{"key":"b4","series-title":"Front Microbiol","first-page":"1204","article-title":"Identification and significance of Weissella species infections","volume":"6","author":"Kamboj","year":"2015"},{"key":"b5","series-title":"Microorganisms","first-page":"2427","article-title":"The Weissella genus: Clinically treatable bacteria with antimicrobial\/probiotic effects on inflammation and cancer","volume":"10","author":"Ahmed","year":"2022"},{"key":"b6","series-title":"BMC Infect Dis","first-page":"69","article-title":"Accuracies of Leuconostoc phenotypic identification: A comparison of API systems and conventional phenotypic assays","volume":"7","author":"Kulwichit","year":"2007"},{"key":"b7","series-title":"J Med Microbiol","first-page":"1539","article-title":"Weissella confusa: A rare cause of vancomycin-resistant gram-positive bacteraemia","volume":"60","author":"Kumar","year":"2011"},{"key":"b8","series-title":"Front Microbiol","first-page":"254","article-title":"Weissella confusa: Problems with identification of an opportunistic pathogen that has been found in fermented foods and proposed as a probiotic","volume":"5","author":"Fairfax","year":"2014"},{"key":"b9","series-title":"Clin Microbiol Infect","first-page":"1226","article-title":"Bacteraemia caused by Weissella confusa at a university hospital in Taiwan, 1997\u20132007","volume":"17","author":"Lee","year":"2011"},{"key":"b10","series-title":"J Clin Microbiol","first-page":"2237","article-title":"Fatal case of endocarditis due to Weissella confusa.","volume":"41","author":"Flaherty","year":"2003"},{"key":"b11","series-title":"Transpl Infect Dis","first-page":"294","article-title":"Weissella confusa: An unexpected cause of vancomycin-resistant gram-positive bacteremia in immunocompromised hosts","volume":"13","author":"Salimnia","year":"2011"},{"key":"b12","series-title":"J Clin Microbiol","first-page":"1604","article-title":"Weissella confusa (basonym: Lactobacillus confusus) bacteremia: A case report","volume":"39","author":"Olano","year":"2001"},{"key":"b13","series-title":"Transpl Infect Dis","first-page":"290","article-title":"Weissella confusa bacteremia in a liver transplant patient with hepatic artery thrombosis","volume":"13","author":"Harlan","year":"2011"},{"key":"b14","series-title":"Can J Infect Dis Med Microbiol","first-page":"173","article-title":"A confusing case \u2013 Weissella confusa prosthetic joint infection: A case report and review of the literature","volume":"25","author":"Medford","year":"2014"},{"key":"b15","series-title":"J Clin Microbiol","first-page":"103595","article-title":"Photo quiz: Confusing bacteremia in a Crohn\u2019s disease patient. Weissella confusa","volume":"53","author":"Vasquez","year":"2015"},{"key":"b16","series-title":"Access Microbiol","first-page":"acmi000119","article-title":"A case report of polymicrobial bacteremia with Weissella confusa and comparison of previous treatment for successful recovery with a review of the literature","volume":"2","author":"Spiegelhauer","year":"2020"},{"key":"b17","series-title":"Food Sci Nutr","first-page":"2896","article-title":"Antimicrobial activity and safety features assessment of Weissella spp. from environmental sources","volume":"10","author":"Fhoula","year":"2022"},{"key":"b18","series-title":"Saudi J Biol Sci","first-page":"103595","article-title":"Evaluation of the antibacterial activity of Weissella confusa K3 cell-free supernatant against extended-spectrum \u03b2eta lactamase (ESBL) producing uropathogenic Escherichia coli U60","volume":"30","author":"El-Mekkawy","year":"2023"},{"key":"b19","series-title":"Cureus","first-page":"e38292","article-title":"Weissella confusa causing vancomycin-resistant septicemia infection in a pediatric patient: A case report from a university teaching hospital in North India","volume":"15","author":"Azim","year":"2023"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/110\/5\/article-p1006.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/110\/5\/article-p1006.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/110\/5\/article-p1006.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T11:05:51Z","timestamp":1714561551000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/110\/5\/article-p1006.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,1]]},"references-count":19,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.23-0713","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,1]]}}}