{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:13:16Z","timestamp":1792131196897,"version":"4.4.0"},"reference-count":45,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Dengue is the most common arboviral disease in the world. Traditionally, it has affected more adults, but the incidence in children has increased in recent years. Colombia is no stranger to this change; therefore, we aimed to find the differences in signs, symptoms, and clinical, hematological, and hemogram characteristics between children under 12\u2009years old and individuals aged 12\u2009years and older in an endemic region of Colombia in 2020\u20132022. The analyses were conducted with baseline data, corresponding to a cross-sectional design. Multiple correspondence analysis was used for general, dermatological, and clinical symptom profiles. Discriminant analysis was used for laboratory profiles. Multiple correspondence analysis was applied to nominal categorical data, employing Euclidean distances to analyze age groups. Discriminant analysis was applied to a training sample and validated on a test sample. The overall agreement of the model\u2019s discrimination, sensitivity, specificity, and fit indicators was calculated. The results indicated that individuals under 12\u2009years exhibited distinct dermatological and clinical features, including rash, pruritus, hypotension, lymphocyte count, and platelet count, compared with those aged 12\u2009years and older. In contrast, those 12\u2009years and older were profiled for general and clinical symptoms such as pain (back pain, retro-orbital pain, headache), dizziness, chills, hematuria, tachypnea, and elevated\/high hematocrit, hemoglobin, and basophil values. These findings are crucial to understanding the high incidence in children; they also facilitate rapid understanding of the disease in clinical care settings and differentiate it from other febrile outbreaks. This will affect disease control, particularly in severe cases, and reduce mortality.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0717","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T15:18:46Z","timestamp":1714576726000},"page":"971-978","source":"Crossref","is-referenced-by-count":26,"title":["Clinical Manifestations of Dengue in Children and Adults in a Hyperendemic Region of Colombia"],"prefix":"10.4269","volume":"110","author":[{"given":"Jorge Emilio","family":"Salazar Fl\u00f3rez","sequence":"first","affiliation":[{"name":"Epidemiology and Biostatistics Group, CES University, Medell\u00edn, Colombia;"},{"name":"Infectious and Chronic Diseases Study Group (GEINCRO), San Mart\u00edn University Foundation, Sabaneta, Colombia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerine","family":"Mar\u00edn Velasquez","sequence":"additional","affiliation":[{"name":"Colombian Institute of Tropical Medicine, CES University, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngela Mar\u00eda","family":"Segura Cardona","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistics Group, CES University, Medell\u00edn, Colombia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berta Nelly","family":"Restrepo Jaramillo","sequence":"additional","affiliation":[{"name":"Colombian Institute of Tropical Medicine, CES University, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuris Esther","family":"Ortega D\u00edaz","sequence":"additional","affiliation":[{"name":"Colombian Institute of Tropical Medicine, CES University, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luz Stella","family":"Giraldo Cardona","sequence":"additional","affiliation":[{"name":"Infectious and Chronic Diseases Study Group (GEINCRO), San Mart\u00edn University Foundation, Sabaneta, Colombia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Arboleda Naranjo","sequence":"additional","affiliation":[{"name":"Colombian Institute of Tropical Medicine, CES University, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Expert Rev Anti Infect Ther","first-page":"1495","article-title":"Dengue vaccine: An update","volume":"19","author":"Huang","year":"2021"},{"key":"b2","series-title":"Parasit Vectors","first-page":"264","article-title":"History, epidemiology and diagnostics of dengue in the American and Brazilian contexts: A review","volume":"11","author":"Salles","year":"2018"},{"key":"b3","series-title":"BioMed Res Int","first-page":"875958","article-title":"Proteomic identification of dengue virus binding proteins in Aedes aegypti mosquitoes and Aedes albopictus cells","volume":"2013","author":"de Lourdes 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