{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:28:31Z","timestamp":1775176111131,"version":"3.50.1"},"reference-count":42,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,6]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p><jats:italic>Histoplasma capsulatum<\/jats:italic> is a thermally dimorphic fungal pathogen endemic to the Mississippi and Ohio River Valley regions of North America and much of Central and South America. As an opportunistic pathogen, <jats:italic>H. capsulatum<\/jats:italic> can assume a latent infection that can be reactivated by immunocompromised states or immunosuppressive therapy. We report a case of a 72-year-old man who lived in rural regions of Panama, Honduras, and Nicaragua while serving in the U.S. military from 1987 to 1991. Three decades after his initial exposure, the patient presented for evaluation of a painful tongue ulcer that originated when he began taking adalimumab to manage his psoriatic arthritis 2 years earlier. Tissue scraping of the tongue ulcer grew a whitish to cream-colored, fluffy-textured mold that was morphologically identified as <jats:italic>Histoplasma<\/jats:italic>. Molecular analysis of the fungus confirmed <jats:italic>H. capsulatum<\/jats:italic> var. Latin American group A, known as <jats:italic>Histoplasma suramericanum<\/jats:italic>. Further testing showed a positive <jats:italic>H. capsulatum<\/jats:italic> antibody mycelial complement fixation, and a 1-cm calcified nodule in the lower lobe of the left lung on computed tomography. Here, we highlight the importance of recognizing disseminated histoplasmosis in patients with exposure to endemic regions before initiating immunosuppressive therapy.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0718","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T14:38:40Z","timestamp":1725979120000},"page":"1133-1137","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Disseminated Histoplasmosis of the Tongue Presenting Decades after Exposure in Latin America"],"prefix":"10.4269","volume":"111","author":[{"given":"Nazareth Jaramillo","family":"Correa","sequence":"first","affiliation":[{"name":"Universidad de Antioquia Facultad de Medicina, Medell\u00edn, Colombia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arunima","family":"Vijay","sequence":"additional","affiliation":[{"name":"University of Florida College of Medicine, Gainesville, Florida;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W.","family":"Merriman","sequence":"additional","affiliation":[{"name":"Division of Hospital Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rochelle G.","family":"Hardie","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norman L.","family":"Beatty","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida;"},{"name":"Emerging Pathogens Institute, University of Florida, Gainesville, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Microbes 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