{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T11:30:10Z","timestamp":1775561410780,"version":"3.50.1"},"reference-count":37,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","license":[{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,3]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Acute gastroenteritis (AGE) in children can be attributed to a multitude of bacterial and viral pathogens. The objective of this study was to investigate the epidemiology of bacterial and viral AGE in children and to compare clinical characteristics between single and multiple enteric pathogen infections. A total of 456 stool samples were collected from outpatient children under 5\u2009years old with AGE, which were subsequently analyzed for nine bacteria and three viruses using the Luminex xTAG<jats:sup>\u00ae<\/jats:sup> Gastrointestinal Pathogen Panel. The presence of at least one pathogen was detected in 260 cases (57.0%), with <jats:italic>Salmonella<\/jats:italic> being the predominant agent, followed by norovirus, <jats:italic>Campylobacter<\/jats:italic>, and rotavirus. A total of 69 cases (15.1%) exhibited positive results for two or more enteric pathogens. Although certain co-infections demonstrated significant differences in primary clinical features compared with mono-infections, no statistical variance was observed in terms of disease severity. In outpatient children from southern China, <jats:italic>Salmonella<\/jats:italic> emerged as the most prevalent causative agent of AGE, succeeded by norovirus and <jats:italic>Campylobacter.<\/jats:italic> This study underscores the burden posed by coinfections and highlights the clinical characteristics associated with AGE when accompanied by coinfections among children under 5\u2009years old.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0725","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T18:35:10Z","timestamp":1709058910000},"page":"809-814","source":"Crossref","is-referenced-by-count":6,"title":["Detection and Characterization of Bacterial and Viral Acute Gastroenteritis among Outpatient Children under 5 Years Old in Guangzhou, China"],"prefix":"10.4269","volume":"110","author":[{"given":"Xin","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Guangdong Women and Children Hospital, Guangzhou, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiankai","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyong","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Guangdong Women and Children Hospital, Guangzhou, China;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Yu","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Infectious Diseases and Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Che","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Infectious Diseases and Division of Laboratory Medicine, Zhujiang Hospital, 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