{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T17:26:15Z","timestamp":1793208375301,"version":"4.5.0"},"reference-count":41,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,3]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>There are no effective therapies for severe fever with thrombocytopenia syndrome (SFTS), and existing predictors of mortality are still controversial. This retrospective study aimed to identify reliable early-stage indicators for predicting fatal outcomes in 217 patients hospitalized with an SFTS diagnosis between March 2021 and November 2023; 157 of the patients survived, and 60 died. Demographics, clinical characteristics, and laboratory parameters were reassessed in both groups. The mean age of participants was 64.0 (interquartile range: 54.5\u201371.0) years, and 42.4% (92\/217) were males. Based on a multivariate Cox regression analysis, the blood urea nitrogen\u2013to\u2013serum albumin ratio (BAR) (hazard ratio [HR]:4.751; 95% CI: 2.208\u201310.226; <jats:italic>P<\/jats:italic> &lt;0.001), procalcitonin level (HR: 1.946; 95% CI: 1.080\u20133.507; <jats:italic>P<\/jats:italic> = 0.027), and central nervous system symptoms (HR: 3.257; 95% CI, 1.628\u20136.513; <jats:italic>P<\/jats:italic> = 0.001) were independent risk factors for mortality in SFTS patients. According to a receiver operating characteristic curve analysis, a BAR with an area under the curve of 0.913 (95% CI: 0.873\u20130.953; <jats:italic>P<\/jats:italic> &lt;0.001), a sensitivity of 76.7%, and a specificity of 90.4% showed better predictive performance for fatal outcomes than other classical indicators reported. The Kaplan-Meier survival curve confirmed that an increased BAR was linked with an unfavorable prognosis in SFTS patients (<jats:italic>P<\/jats:italic> &lt;0.001 by log-rank test). In conclusion, the results indicate that high BAR levels are markedly related to substandard outcomes and are a reliable and readily accessible predictor of fatal outcomes in SFTS patients.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0811","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T18:07:49Z","timestamp":1716919669000},"page":"113-120","source":"Crossref","is-referenced-by-count":9,"title":["Blood Urea Nitrogen\u2013to\u2013Serum Albumin Ratio Predicts Fatal Outcomes in Severe Fever with Thrombocytopenia Syndrome Patients"],"prefix":"10.4269","volume":"111","author":[{"given":"Kangli","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Along","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuntao","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Clinical Medical School of Anhui Medical University, Hefei, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjian","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cairui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binhang","family":"Han","sequence":"additional","affiliation":[{"name":"The First Clinical Medical School of Anhui Medical University, Hefei, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"N Engl J Med","first-page":"1523","article-title":"Fever with thrombocytopenia associated with a novel bunyavirus in 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