{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T12:35:07Z","timestamp":1782995707919,"version":"3.54.5"},"reference-count":17,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,5]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>In this article, we report a male patient infected with HIV presenting with cryptococcal meningitis, pneumonia, and bloodstream infection, along with intestinal obstruction and gastrointestinal bleeding. Cerebrospinal fluid and bloodstream analyses revealed the presence of <jats:italic>Cryptococcus neoformans<\/jats:italic> complex. The isolated strain was sequenced and was found to belong to <jats:italic>Cryptococcus neoformans var. grubii<\/jats:italic> with a new sequence type (ST). The strain led to fatal multisystemic cryptococcosis in a short time, and the patient died due to hemorrhagic shock because of gastrointestinal bleeding despite emergency rescue efforts. There are few reports about cryptococcosis in HIV-infected patients caused by new ST isolates. We report a new <jats:italic>Cryptococcus neoformans<\/jats:italic> ST (ST702) isolate causing infection in an HIV-infected patient, which merits further study and clinical attention.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0818","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T14:27:50Z","timestamp":1732631270000},"page":"373-376","source":"Crossref","is-referenced-by-count":2,"title":["A Case of Cryptococcosis Due to a New Cryptococcus Neoformans Sequence Type in a Patient with Human Immunodeficiency Virus Infection"],"prefix":"10.4269","volume":"112","author":[{"given":"Fangfang","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Beijing Youan Hospital, Capital Medical University, Beijing, China;"},{"name":"Beijing Tongren Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhua","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Beijing Youan Hospital, Capital Medical University, Beijing, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinli","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Beijing Youan Hospital, Capital Medical University, Beijing, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxin","family":"Lu","sequence":"additional","affiliation":[{"name":"Beijing Tongren Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Am J Med","first-page":"19","article-title":"Cryptococcal infections in patients with acquired immune deficiency syndrome","volume":"81","author":"Eng","year":"1986"},{"key":"b2","series-title":"Front Microbiol","first-page":"942940","article-title":"Molecular epidemiology and antifungal resistance of Cryptococcus neoformans from human immunodeficiency virus-negative and human immunodeficiency virus-positive patients in eastern China","volume":"13","author":"Zhou","year":"2022"},{"key":"b3","series-title":"Med Mycol","first-page":"561","article-title":"Consensus multi-locus sequence typing scheme for Cryptococcus neoformans and Cryptococcus gattii","volume":"47","author":"Meyer","year":"2009"},{"key":"b4","series-title":"Clin Infect Dis","first-page":"47","article-title":"Diagnosis and management of increased intracranial pressure in patients with AIDS and cryptococcal meningitis","volume":"30","author":"Graybill","year":"2000"},{"key":"b5","series-title":"Clin Case Rep","first-page":"e6353","article-title":"Neuromeningeal cryptococcosis in a patient not infected with human immunodeficiency virus and without known risk factors: A case report","volume":"14","author":"Andrianiaina","year":"2022"},{"key":"b6","series-title":"Mycopathologia","first-page":"81","article-title":"Intra-abdominal cryptococcosis by Cryptococcus gattii: Case report and review","volume":"174","author":"Ara\u00fajo","year":"2012"},{"key":"b7","series-title":"Int J Infect Dis","first-page":"e436","article-title":"Colitis as a manifestation of in\ufb02iximab-associated disseminated cryptococcosis","volume":"14","author":"Osawa","year":"2010"},{"key":"b8","series-title":"J R Soc Med","first-page":"513","article-title":"Cryptococcal small-bowel obstruction in an HIV-positive patient","volume":"98","author":"Nawabi","year":"2005"},{"key":"b9","series-title":"Med Mycol Case Rep","first-page":"40","article-title":"Gastrointestinal cryptococcoma-immune reconstitution inflammatory syndrome or cryptococcal relapse in a patient with AIDS?","volume":"8","author":"Musubire","year":"2015"},{"key":"b10","series-title":"Gastroenterology","first-page":"1882","article-title":"Small bowel perforation in a patient with AIDS","volume":"140","author":"Tzimas","year":"2011"},{"key":"b11","series-title":"Curr Opin Infect Dis","first-page":"16","article-title":"Emerging concepts in HIV associated cryptococcal meningitis","volume":"32","author":"Lawrence","year":"2019"},{"key":"b12","series-title":"PLoS One","first-page":"e0267842","article-title":"Clinical epidemiology and high genetic diversity amongst Cryptococcus spp. isolates infecting people living with HIV in Kinshasa, Democratic Republic of Congo","volume":"17","author":"Bive","year":"2022"},{"key":"b13","series-title":"Fungal Genet Biol","first-page":"16","article-title":"Genotypes and population genetics of Cryptococcus neoformans and Cryptococcus gattii species complexes in Europe and the mediterranean area","volume":"129","author":"Cogliati","year":"2019"},{"key":"b14","series-title":"Mycopathologia","first-page":"199","article-title":"Multilocus sequence typing of clinical isolates of Cryptococcus from India","volume":"186","author":"Xess","year":"2021"},{"key":"b15","series-title":"J Clin Microbiol","first-page":"658","article-title":"Most cases of cryptococcal meningitis in HIV-uninfected patients in Vietnam are due to a distinct amplified fragment length polymorphism-defined cluster of Cryptococcus neoformans var. grubii VN1","volume":"49","author":"Day","year":"2011"},{"key":"b16","series-title":"Med Mycol","first-page":"252","article-title":"Multilocus sequence typing of Cryptococcus neoformans in non-HIV associated cryptococcosis in Nagasaki, Japan","volume":"51","author":"Mihara","year":"2013"},{"key":"b17","series-title":"Int J Infect Dis","first-page":"244","article-title":"Characteristics and prognostic risk factors of patients with sequence type 5 lineage-associated cryptococcosis in China","volume":"128","author":"Tian","year":"2023"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/112\/2\/article-p373.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/112\/2\/article-p373.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/112\/2\/article-p373.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T18:43:38Z","timestamp":1738781018000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/112\/2\/article-p373.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,5]]},"references-count":17,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.23-0818","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,5]]}}}