{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:30:01Z","timestamp":1790832601424,"version":"4.1.0"},"reference-count":37,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,7]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Leptospirosis is a neglected zoonosis for which investigations assessing host-pathogen interaction are scarce. The aim of this study was to compare the severity and bacterial species involved in human cases of leptospirosis on Reunion and Mayotte islands, territories located in the southwest Indian Ocean that have recorded high human leptospirosis incidence but display fairly distinct epidemiological situations. A retrospective multicentric study including all patients over 18 years of age from Mayotte or Reunion with proven leptospirosis was conducted from January 2018 to April 2020. This study collected demographic, geographical, clinical, and biological data. Overall, 490 patients were included, 222 on Mayotte and 268 on Reunion. More patients were hospitalized on Reunion (<jats:italic>n<\/jats:italic> = 215, 80%) compared with Mayotte (<jats:italic>n<\/jats:italic> = 102, 46%). Severe disease was more common on Reunion (<jats:italic>n<\/jats:italic> = 75, 28%) than on Mayotte (<jats:italic>n<\/jats:italic> = 22, 10%). The dominant Leptospira species on Reunion was <jats:italic>Leptospira interrogans<\/jats:italic> (79%) followed by <jats:italic>Leptospira borgpetersenii<\/jats:italic> (21%), contrasting with the epidemiological situation on Mayotte where <jats:italic>L. interrogans<\/jats:italic> was found in only a minority of patients (10%). The high frequency of severe cases on Reunion could be explained not only by higher comorbidities but also by the higher occurrence of <jats:italic>L. interrogans<\/jats:italic> infections compared with Mayotte. Finally, the distribution of cases linked to <jats:italic>L. borgpetersenii<\/jats:italic> was found almost exclusively on the west coast of Reunion, raising the potential role of a ruminant reservoir.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0846","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T13:16:03Z","timestamp":1719926163000},"page":"237-245","source":"Crossref","is-referenced-by-count":7,"title":["A Comparative Study of Human Leptospirosis between Mayotte and Reunion Islands Highlights Distinct Clinical and Microbial Features Arising from Distinct Inter-Island Bacterial Ecology"],"prefix":"10.4269","volume":"111","author":[{"given":"Anissa","family":"Desmoulin","sequence":"first","affiliation":[{"name":"Centre Hospitalier Universitaire de La R\u00e9union, Saint-Pierre, France;"},{"name":"Centre Hospitalier de Mayotte, Mamoudzou, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arline","family":"Rajaonarivelo","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche Processus Infectieux en Milieu Insulaire Tropical (UMR PIMIT), Universit\u00e9 de La R\u00e9union, CNRS 9192, INSERM 1187, IRD 249, Plateforme de recherche CYROI, Sainte-Clotilde, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Maillard","sequence":"additional","affiliation":[{"name":"Centre d\u2019Investigation Clinique, INSERM CIC 1410, Saint-Pierre, France;"},{"name":"Centre Hospitalier Universitaire de La R\u00e9union, Saint-Denis, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis","family":"Collet","sequence":"additional","affiliation":[{"name":"Centre Hospitalier de Mayotte, Mamoudzou, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Jaffar-Bandjee","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de La R\u00e9union, Saint-Denis, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Pierre","family":"Moiton","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de La R\u00e9union, Saint-Denis, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Poubeau","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de La R\u00e9union, Saint-Pierre, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Fayeulle","sequence":"additional","affiliation":[{"name":"Groupe Hospitalier Est R\u00e9union, Saint-Beno\u00eet, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Fran\u00e7ois-Wattrelot","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Ouest R\u00e9union, Saint-Paul, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Blond\u00e9","sequence":"additional","affiliation":[{"name":"Centre Hospitalier de Mayotte, Mamoudzou, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Tortosa","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche Processus Infectieux en Milieu Insulaire Tropical (UMR PIMIT), Universit\u00e9 de La R\u00e9union, CNRS 9192, INSERM 1187, IRD 249, Plateforme de recherche CYROI, Sainte-Clotilde, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efc","family":"Raffray","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche Processus Infectieux en Milieu Insulaire Tropical (UMR PIMIT), Universit\u00e9 de La R\u00e9union, CNRS 9192, INSERM 1187, IRD 249, Plateforme de recherche CYROI, Sainte-Clotilde, France;"},{"name":"Centre Hospitalier Universitaire de La R\u00e9union, Saint-Denis, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"PLoS Negl Trop Dis","first-page":"e0003898","article-title":"Global morbidity and mortality of leptospirosis: A systematic review","volume":"9","author":"Costa","year":"2015"},{"key":"b2","series-title":"Clin Microbiol Rev","first-page":"296","article-title":"Leptospirosis","volume":"14","author":"Levett","year":"2001"},{"key":"b3","series-title":"PLoS Negl Trop Dis","first-page":"e0004039","article-title":"Leptospirosis: Updating the global picture of an emerging neglected disease","volume":"9","author":"Picardeau","year":"2015"},{"key":"b4","series-title":"Scand J Immunol","first-page":"408","article-title":"Leptospirosis: Aspects of innate immunity, 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