{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:20:39Z","timestamp":1788477639182,"version":"build-2803163510"},"reference-count":8,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,3]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Human strongyloidiasis is a potentially life-threatening parasitic disease among immunocompromised hosts. We aim to determine the factors and mortality associated with disseminated strongyloidiasis. We conducted a U.S.-based multicenter retrospective cohort study to determine 90-day clinical outcomes for people diagnosed with <jats:italic>Strongyloides<\/jats:italic> infection in the TriNetX patient database. We identified adult patients with the <jats:italic>International Classification of Diseases<\/jats:italic> (10th revision, clinical modification) code for <jats:italic>Strongyloides<\/jats:italic> infection (B78) or a positive <jats:italic>Strongyloides<\/jats:italic> IgG antibody test and captured outcomes at 90 days. We identified 5,434 patients with strongyloidiasis, of whom 48 had disseminated strongyloidiasis for 0.9% prevalence of disseminated disease. Systemic connective tissue disorders, pulmonary eosinophilia, liver cirrhosis, blood disorders (monoclonal gammopathy, aplastic anemia, and lymphoid malignancy), malnutrition, alcohol use disorder, and transplantation status were frequent in patients with disseminated disease. Mortality was significantly higher in people with disseminated disease at 30 days (21%). The 90-day risk of hospitalization, bacteremia, and acute respiratory distress syndrome (ARDS) was higher in those with disseminated infection. People with disseminated strongyloidiasis had a heightened risk of hospitalization, bacteremia, acute respiratory distress syndrome, and mortality. The population at risk for severe strongyloidiasis infection is evolving, reflecting conditions in which glucocorticoids or additional immunosuppressive medications are commonly used for treatment.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0863","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T18:06:00Z","timestamp":1716919560000},"page":"89-92","source":"Crossref","is-referenced-by-count":6,"title":["Clinical Characteristics and Outcomes of Disseminated Strongyloidiasis in the United States\u2014A Multicenter Network Analysis"],"prefix":"10.4269","volume":"111","author":[{"given":"Andr\u00e9s F.","family":"Henao-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of Colorado Denver, Aurora, Colorado;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Olivo Freites","sequence":"additional","affiliation":[{"name":"Ryan Health, Infectious Diseases, New York, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson I.","family":"Agudelo Higuita","sequence":"additional","affiliation":[{"name":"University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma;"},{"name":"Instituto de Enfermedades Infecciosas y de Parasitolog\u00eda Antonio Vidal, Tegucigalpa, Honduras;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A.","family":"Marcos","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Departments of Medicine, Microbiology and Immunology, Stony Brook University, Stony Brook, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel B.","family":"Chastain","sequence":"additional","affiliation":[{"name":"Department of Clinical and Administrative Pharmacy, University of Georgia College of Pharmacy, Albany, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir M.","family":"Mohareb","sequence":"additional","affiliation":[{"name":"Center for Global Health, Massachusetts General Hospital, Boston, Massachusetts;"},{"name":"Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts;"},{"name":"Department of Medicine, Harvard Medical School, Boston, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Tuells","sequence":"additional","affiliation":[{"name":"Department of Community Nursing, Preventive Medicine and Public Health and History of Science, University of Alicante, Alicante, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Villalpando-Carrion","sequence":"additional","affiliation":[{"name":"Hospital Infantil de M\u00e9xico, Ciudad de M\u00e9xico, M\u00e9xico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Franco-Paredes","sequence":"additional","affiliation":[{"name":"Hospital Infantil de M\u00e9xico, Ciudad de M\u00e9xico, M\u00e9xico;"},{"name":"Instituto Conmemorativo Gorgas de Estudios de la Salud, Panama City, Republic of Panama;"},{"name":"Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Parasitology","first-page":"263","article-title":"Human infection with Strongyloides stercoralis and other related Strongyloides species","volume":"144","author":"Nutman","year":"2017"},{"key":"b2","series-title":"Ther Adv Infect Dis","first-page":"20499361231159481","article-title":"Previous corticosteroid exposure associates with an increased Pneumocystis jirovecii pneumonia mortality among HIV-negative patients: A global research network with a follow-up multicenter case\u2013control study","volume":"10","author":"Vargas Barahona","year":"2023"},{"key":"b3","series-title":"Ther Adv Infect Dis","first-page":"20499361231196683","article-title":"Hospitalization risk among patients with mpox infection \u2013 A propensity score matched analysis","volume":"10","author":"Henao-Mart\u00ednez","year":"2023"},{"key":"b4","series-title":"Infection","first-page":"691","article-title":"Strongyloides stercoralis hyperinfection syndrome: A case series and a review of the literature","volume":"43","author":"Geri","year":"2015"},{"key":"b5","series-title":"Front Med (Lausanne)","first-page":"832430","article-title":"Human T-cell lymphotropic virus type 1 and Strongyloides stercoralis co-infection: A systematic review and meta-analysis","volume":"9","author":"Ye","year":"2022"},{"key":"b6","series-title":"Curr Infect Dis Rep","first-page":"35","article-title":"Update on strongyloidiasis in the immunocompromised host","volume":"13","author":"Marcos","year":"2011"},{"key":"b7","series-title":"Rev Infect Dis","first-page":"397","article-title":"Syndrome of hyperinfection with Strongyloides stercoralis","volume":"3","author":"Igra-Siegman","year":"1981"},{"key":"b8","series-title":"Clin Infect Dis","first-page":"1548","article-title":"Hospitalizations associated with strongyloidiasis in the United States, 2003\u20132018","volume":"75","author":"Inagaki","year":"2022"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/111\/1\/article-p89.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/111\/1\/article-p89.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/111\/1\/article-p89.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T13:34:13Z","timestamp":1720013653000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/111\/1\/article-p89.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,3]]},"references-count":8,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.23-0863","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,3]]}}}