{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:29:51Z","timestamp":1771036191270,"version":"3.50.1"},"reference-count":20,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,4]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Zika virus (ZIKV) infection in pregnancy is associated with severe abnormalities of the brain and eye and other adverse outcomes. Zika en Embarazadas y Ni\u00f1os was a prospective cohort study conducted in multiple Colombian cities that enrolled pregnant women in their first trimester. Specimens collected from pregnant women (<jats:italic>n<\/jats:italic> = 1,519) during February 2017\u2013September 2018 and their infants (<jats:italic>n<\/jats:italic> = 1,080) during June 2017\u2013March 2019 were tested for prenatal ZIKV infection by nucleic acid amplification tests or IgM antibody testing. Zika virus infection in pregnancy was present in 3.2% of pregnant women (incidence rate [IR] per 1,000 person-months = 5.9, 95% CI: 4.3\u20137.8). Presumptive ZIKV infection was present in 0.8% of infants (IR = 1.6, 95% CI: 0.7\u20132.9). Five percent of infants with prenatal ZIKV exposure or infection presented with Zika-associated abnormalities; 4.7% were small for gestational age. Understanding the risk of ZIKV infection during pregnancy and associated adverse outcomes can help inform counseling efforts.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0873","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T13:37:23Z","timestamp":1720532243000},"page":"622-626","source":"Crossref","is-referenced-by-count":1,"title":["Birth Outcomes Related to Prenatal Zika, Dengue, and Other Flavivirus Infections in the Zika en Embarazadas y Ni\u00f1os Prospective Cohort Study in Colombia"],"prefix":"10.4269","volume":"111","author":[{"given":"Ayzsa","family":"Tannis","sequence":"first","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia;"},{"name":"Eagle Global Scientific, LLC, San Antonio, Texas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Newton","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelica","family":"Rico","sequence":"additional","affiliation":[{"name":"Division of Research in Public Health, National Institute of Health, Bogota, Colombia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maritza","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Division of Research in Public Health, National Institute of Health, Bogota, Colombia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Benavides","sequence":"additional","affiliation":[{"name":"Maternal and Perinatal Research Division, National Institute of Health, Bogota, Colombia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica N.","family":"Ricaldi","sequence":"additional","affiliation":[{"name":"National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Division of Research in Public Health, National Institute of Health, Bogota, Colombia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura D.","family":"Zambrano","sequence":"additional","affiliation":[{"name":"National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Daza","sequence":"additional","affiliation":[{"name":"Maternal and Perinatal Research Division, National Institute of Health, Bogota, Colombia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shana","family":"Godfred-Cato","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer D.","family":"Thomas","sequence":"additional","affiliation":[{"name":"National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Acosta","sequence":"additional","affiliation":[{"name":"Research Division, Vysnova Partners, Bethesda, Maryland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagiotis","family":"Maniatis","sequence":"additional","affiliation":[{"name":"National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan B.","family":"Daniels","sequence":"additional","affiliation":[{"name":"Office of Readiness and Response, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Burkel","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia;"},{"name":"Eagle Global Scientific, LLC, San Antonio, Texas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth C.","family":"Ailes","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Valencia","sequence":"additional","affiliation":[{"name":"National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne M.","family":"Gilboa","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise J.","family":"Jamieson","sequence":"additional","affiliation":[{"name":"Carver College of Medicine, University of Iowa, Iowa City, Iowa;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Mercado","sequence":"additional","affiliation":[{"name":"Maternal and Perinatal Research Division, National Institute of Health, Bogota, Colombia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie M.","family":"Villanueva","sequence":"additional","affiliation":[{"name":"National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret A.","family":"Honein","sequence":"additional","affiliation":[{"name":"National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha L.","family":"Ospina","sequence":"additional","affiliation":[{"name":"Global Health Department, Robert Stempel College of Public Health & Social Work, Florida International University, Miami, Florida;"},{"name":"Department of Health Sciences, Simon Boliviar University, Bogota, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Van T.","family":"Tong","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Reprod Health","first-page":"28","article-title":"Zika virus infection in pregnancy: A systematic review of disease course and complications","volume":"14","author":"Chibueze","year":"2017"},{"key":"b2","series-title":"JAMA Pediatr","first-page":"288","article-title":"Characterizing the pattern of anomalies in congenital Zika syndrome for pediatric clinicians","volume":"171","author":"Moore","year":"2017"},{"key":"b3","series-title":"BMJ Open","first-page":"e023529","article-title":"Dengue during pregnancy and live birth outcomes: A cohort of linked data from Brazil","volume":"9","author":"Paix\u00e3o","year":"2019"},{"key":"b4","series-title":"N Engl J Med","first-page":"1981","article-title":"Zika virus and birth defects\u2013Reviewing the evidence for causality","volume":"374","author":"Rasmussen","year":"2016"},{"key":"b5","series-title":"MMWR Morb Mortal Wkly Rep","first-page":"73","article-title":"Zika-associated birth defects reported in pregnancies with laboratory evidence of confirmed or possible Zika virus infection \u2013 U.S. Zika Pregnancy and Infant Registry, December 1, 2015\u2013March 31, 2018","volume":"71","author":"Roth","year":"2022"},{"key":"b6","series-title":"MMWR Morb Mortal Wkly Rep","first-page":"1409","article-title":"Preliminary report of microcephaly potentially associated with Zika virus infection during pregnancy \u2013 Colombia, January\u2013November 2016","volume":"65","author":"Cuevas","year":"2016"},{"key":"b7","series-title":"Arch Public Health","first-page":"65","article-title":"Zika virus disease, microcephaly and Guillain-Barr\u00e9 syndrome in Colombia: Epidemiological situation during 21 months of the Zika virus outbreak, 2015\u20132017","volume":"75","author":"M\u00e9ndez","year":"2017"},{"key":"b8","series-title":"N Engl J Med","first-page":"537","article-title":"Zika virus disease and pregnancy outcomes in Colombia","volume":"383","author":"Ospina","year":"2020"},{"key":"b9","series-title":"Epidemiol Health","first-page":"e2020060","article-title":"Cohort profile: Congenital Zika virus infection and child neurodevelopmental outcomes in the ZEN cohort study in Colombia","volume":"42","author":"Gonzalez","year":"2020"},{"key":"b10","series-title":"Nat Commun","first-page":"1391","article-title":"Performance of the Trioplex real-time RT-PCR assay for detection of Zika, dengue, and chikungunya viruses","volume":"9","author":"Santiago","year":"2018"},{"key":"b11","series-title":"MMWR Morb Mortal Wkly Rep","first-page":"1","article-title":"Dengue and Zika virus diagnostic testing for patients with a clinically compatible illness and risk for infection with both viruses","volume":"68","author":"Sharp","year":"2019"},{"key":"b12","series-title":"Am J Trop Med Hyg","first-page":"37","article-title":"Age distribution of lymphocytic choriomeningitis virus serum antibody in Birmingham, Alabama: Evidence of a decreased risk of infection","volume":"57","author":"Park","year":"1997"},{"key":"b13","series-title":"BJOG","first-page":"9","article-title":"The objectives, design and implementation of the INTERGROWTH-21st Project","volume":"120","author":"Villar","year":"2013"},{"key":"b14","series-title":"Cities","first-page":"102560","article-title":"Assessing Colombia\u2019s policy of socio-economic stratification: An intra-city study of self-reported quality of life","volume":"97","author":"Chica-Olmo","year":"2020"},{"key":"b15","year":"2017"},{"key":"b16","year":"2018"},{"key":"b17","series-title":"Nat Commun","first-page":"632","article-title":"Shifting patterns of dengue three years after Zika virus emergence in Brazil","volume":"15","author":"Pinotti","year":"2024"},{"key":"b18","series-title":"J Med Virol","first-page":"6393","article-title":"Epidemiology of cytomegalovirus infection among mothers and infants in Colombia","volume":"93","author":"Rico","year":"2021"},{"key":"b19","series-title":"BMJ Open","first-page":"e026092","article-title":"Understanding the relation between Zika virus infection during pregnancy and adverse fetal, infant and child outcomes: A protocol for a systematic review and individual participant data meta-analysis of longitudinal studies of pregnant women and their infants and children","volume":"9","author":"Wilder-Smith","year":"2019"},{"key":"b20","series-title":"Pediatr Res","first-page":"414","article-title":"Preparing for the next emerging perinatal infectious disease","volume":"95","author":"Buekens","year":"2024"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/111\/3\/article-p622.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/111\/3\/article-p622.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/111\/3\/article-p622.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T20:00:27Z","timestamp":1725480027000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/111\/3\/article-p622.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,4]]},"references-count":20,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.23-0873","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,4]]}}}