{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:15:06Z","timestamp":1723076106333},"reference-count":73,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,7]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Antimicrobial resistance (AMR) in the community is increasing worldwide. We aimed to assess AMR trends in <jats:italic>Escherichia coli<\/jats:italic> from the community urine isolates in French Amazonia. We conducted a retrospective study from January 2016 to December 2022 in the Cayenne General Hospital microbiology laboratory (French Guiana). It included all urine samples positive for <jats:italic>E. coli<\/jats:italic> collected from adult outpatients. During the study period, 3,443 urinalyses positive for <jats:italic>E. coli<\/jats:italic> were studied. In 46% of cases, patients were women. In 64.4% of cases, <jats:italic>E. coli<\/jats:italic> were \u03b2-lactamase producers. The most frequently diagnosed resistance mechanisms were penicillinase production and sparing third-generation cephalosporins. Isolated <jats:italic>E. coli<\/jats:italic> were extended-spectrum \u03b2-lactamase (ESBL) producers in 6.1% of cases. Overall, <jats:italic>E. coli<\/jats:italic> was susceptible to amoxicillin in 35.9% [95% CI: 34.3\u201337.5], to amoxicillin\/clavulanic acid in 62.2% [95% CI: 60.6\u201363.9], to cefotaxime in 94% [95% CI: 93.1\u201394.7], to gentamicin in 92.1% [95% CI: 89.1\u201392.6], to ofloxacin in 76.8% [95% CI: 75.3\u201378.2], to trimethoprim\/sulfamethoxazole (SXT) in 58.8% [95% CI: 57.1\u201360.5], to fosfomycin in 99.1% [95% CI: 98.6\u201399.4], and to nitrofurantoin in 99% of cases [95% CI: 98.6\u201399.3]. We have observed a gradual decline in the susceptibility profile of <jats:italic>E. coli<\/jats:italic> for amoxicillin\/clavulanic acid (<jats:italic>P<\/jats:italic> &lt;0.001), piperacillin\/tazobactam (<jats:italic>P<\/jats:italic> = 0.003), and temocillin (<jats:italic>P<\/jats:italic> = 0.006). However, susceptibility to ciprofloxacin was increasing (<jats:italic>P<\/jats:italic> = 0.001). In contrast, the susceptibility trends for amoxicillin, third-generation cephalosporins, gentamicin, SXT, nitrofurantoin, and fosfomycin remained stable over the 28 quarters of the study. In conclusion, isolated <jats:italic>E. coli<\/jats:italic> from outpatient urinalyses showed increased resistance profiles involving penicillinase and ESBL production. Close monitoring and strategies to decrease antibiotic consumption in the community are needed.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0887","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T13:32:02Z","timestamp":1719322322000},"page":"287-296","source":"Crossref","is-referenced-by-count":0,"title":["Trends in the Prevalence of Antimicrobial Resistance in Escherichia coli Isolated from Outpatient Urine Cultures in French Amazonia"],"prefix":"10.4269","volume":"111","author":[{"given":"Flaubert","family":"Nkontcho Djamkeba","sequence":"first","affiliation":[{"name":"Pharmacy Department, Cayenne General Hospital, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Sainte-Rose","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Cayenne General Hospital, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy Roger","family":"Lontsi Ngoulla","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Cayenne General Hospital, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariane","family":"Roujansky","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Cayenne General Hospital, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Abboud","sequence":"additional","affiliation":[{"name":"Tropical and Infectious Diseases Department, Cayenne General Hospital, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaelle","family":"Walter","sequence":"additional","affiliation":[{"name":"Tropical and Infectious Diseases Department, Cayenne General Hospital, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Houcke","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Cayenne General Hospital, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magalie","family":"Demar","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology, Cayenne General Hospital, French Guiana;"},{"name":"Tropical Biome and immunopathology CNRS UMR-9017, Inserm U 1019, Universit\u00e9 de Guyane, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hatem","family":"Kallel","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Cayenne General Hospital, French Guiana;"},{"name":"Tropical Biome and immunopathology CNRS UMR-9017, Inserm U 1019, Universit\u00e9 de Guyane, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Marc","family":"Pujo","sequence":"additional","affiliation":[{"name":"Emergency Department, Cayenne General Hospital, French Guiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Djossou","sequence":"additional","affiliation":[{"name":"Tropical and Infectious Diseases Department, Cayenne General Hospital, French Guiana;"},{"name":"Tropical Biome and immunopathology CNRS UMR-9017, Inserm U 1019, Universit\u00e9 de Guyane, French Guiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Lancet","first-page":"629","article-title":"Global burden of bacterial antimicrobial resistance in 2019: A systematic analysis","volume":"399","author":"Murray","year":"2022"},{"year":"2022","series-title":"Assessing the Health Burden of Infections with Antibiotic-Resistant Bacteria in the EU\/EEA, 2016\u20132020","key":"b2"},{"key":"b3","series-title":"Infect Control Hosp Epidemiol","first-page":"49","article-title":"Increasing incidence of extended-spectrum \u03b2-lactamase-producing Escherichia coli in community hospitals throughout the southeastern United States","volume":"37","author":"Thaden","year":"2016"},{"key":"b4","series-title":"Lancet Public Health","first-page":"e897","article-title":"The burden of bacterial antimicrobial resistance in the WHO European region in 2019: A cross-country systematic analysis","volume":"7","author":"Mestrovic","year":"2022"},{"year":"2023","series-title":"Surveillance de la r\u00e9sistance bact\u00e9rienne aux antibiotiques en soins de ville et en \u00e9tablissements pour personnes \u00e2g\u00e9es d\u00e9pendantes. 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