{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:08:16Z","timestamp":1792440496451,"version":"4.5.0"},"reference-count":31,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,8]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>Dengue is the most important viral vector-borne disease in the tropics, with Colombia being one of the most affected countries. In this context, it is essential to identify and synthesize the existing evidence on the epidemiology of dengue in Colombia. A systematic review (PROSPERO CRD42021257985) was conducted by searching for epidemiological data in populations with suspected or confirmed dengue in Colombia from 2012 to 2020. We searched PubMed, EMBASE, the Cochrane Library, the LILACS, and SciELO databases, and 104 publications out of 1,234 records were selected. The dengue annual incidence rate varied through the years without a clear trend. The lowest annual incidence rate was observed in 2017 (90.7 per 100,000 population) and the highest in 2013 (476.2 per 100,000 population). The proportion of severe cases in the same period ranged between 0.89% in 2016 and 2.7% in 2012. The four dengue virus (DENV) serotypes co-circulated in the country, and DENV-2 was the predominant serotype. Fifty percent of dengue cases occurred in people under 20\u2009years, and those between 5 and 14\u2009years had the highest incidence rate. The mortality rate for all dengue cases ranged from 0.07% in 2020 to 0.16% in 2012 and 2015. In conclusion, dengue is a hyperendemic disease in Colombia with the circulation of four serotypes. New strategies must be implemented to prevent the contagion and impact of the disease on the population at risk.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0907","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T17:23:49Z","timestamp":1730222629000},"page":"182-188","source":"Crossref","is-referenced-by-count":24,"title":["The Epidemiological Impact of Dengue in Colombia: A Systematic Review"],"prefix":"10.4269","volume":"112","author":[{"given":"Alfonso J.","family":"Rodr\u00edguez-Morales","sequence":"first","affiliation":[{"name":"Grupo de Investigaci\u00f3n Biomedicina, Faculty of Medicine, Fundaci\u00f3n Universitaria Aut\u00f3noma de las Am\u00e9ricas-Instituci\u00f3n Universitaria Visi\u00f3n de las Am\u00e9ricas, Pereira, Colombia;"},{"name":"Master of Clinical Epidemiology and Biostatistics, Universidad Cient\u00edfica del Sur, Lima, Per\u00fa;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"L\u00f3pez-Medina","sequence":"additional","affiliation":[{"name":"Colombian Association of Infectious Diseases (ACIN), Bogot\u00e1, Colombia;"},{"name":"Department of Pediatrics, Universidad del Valle, Cali, Colombia;"},{"name":"Centro de Estudios en Infectolog\u00eda Pedi\u00e1trica, Cali, Colombia;"},{"name":"Cl\u00ednica Imbanaco, Grupo Quir\u00f3n Salud, Cali, Colombia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n","family":"Arboleda","sequence":"additional","affiliation":[{"name":"Baxalta Colombia SAS, (Takeda), Bogot\u00e1, Colombia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime A.","family":"Cardona-Ospina","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n Biomedicina, Faculty of Medicine, Fundaci\u00f3n Universitaria Aut\u00f3noma de las Am\u00e9ricas-Instituci\u00f3n Universitaria Visi\u00f3n de las Am\u00e9ricas, Pereira, Colombia;"},{"name":"Colombian Association of Infectious Diseases (ACIN), Bogot\u00e1, Colombia;"},{"name":"Grupo de Investigaci\u00f3n en Infecciones Emergentes y Medicina Tropical, Instituto para la Investigaci\u00f3n en Ciencias Biom\u00e9dicas, SCI-HELP, Pereira, Colombia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime E.","family":"Castellanos","sequence":"additional","affiliation":[{"name":"Colombian Association of Infectious Diseases (ACIN), Bogot\u00e1, Colombia;"},{"name":"Universidad El Bosque, Vicerrector\u00eda de Investigaci\u00f3n, Grupo de Virolog\u00eda, Bogot\u00e1, Colombia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro A.","family":"Faccini-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Servicio de Infectolog\u00eda, Hospital Militar Central, Bogot\u00e1, Colombia;"},{"name":"Facultad de Medicina, Universidad Militar Nueva Granada, Bogot\u00e1, Colombia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Takeda Pharmaceuticals International AG, Zurich, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riona","family":"Hanley","sequence":"additional","affiliation":[{"name":"Takeda Pharmaceuticals International AG, Zurich, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pio","family":"Lopez","sequence":"additional","affiliation":[{"name":"Colombian Association of Infectious Diseases (ACIN), Bogot\u00e1, Colombia;"},{"name":"Department of Pediatrics, Universidad del Valle, Cali, Colombia;"},{"name":"Centro de Estudios en Infectolog\u00eda Pedi\u00e1trica, Cali, Colombia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim","family":"Mattar","sequence":"additional","affiliation":[{"name":"Colombian Association of Infectious Diseases (ACIN), Bogot\u00e1, Colombia;"},{"name":"Instituto de Investigaciones Biol\u00f3gicas del Tr\u00f3pico, Universidad de C\u00f3rdoba, Monter\u00eda, Colombia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Eduardo","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Colombian Association of Infectious Diseases (ACIN), Bogot\u00e1, Colombia;"},{"name":"Servicios y Asesor\u00edas en Infectolog\u00eda, Bogot\u00e1, Colombia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randee","family":"Kastner","sequence":"additional","affiliation":[{"name":"Takeda Pharmaceuticals International AG, Zurich, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto","family":"Reynales","sequence":"additional","affiliation":[{"name":"Centro de Atenci\u00f3n e Investigaci\u00f3n M\u00e9dica \u2013 CAIMED, Ch\u00eda, Colombia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Rosso","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Valle del Lili, Infectious Diseases Service, Cali, Colombia;"},{"name":"Universidad Icesi - Facultad de Ciencias de la Salud, Cali, Colombia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Shen","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biol\u00f3gicas del Tr\u00f3pico, Universidad de C\u00f3rdoba, Monter\u00eda, Colombia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilmer E.","family":"Villamil-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Colombian Association of Infectious Diseases (ACIN), Bogot\u00e1, Colombia;"},{"name":"Universidad Sim\u00f3n Bol\u00edvar, Centro de Investigaci\u00f3n en Ciencias de la Vida, Barranquilla, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Fuquen","sequence":"additional","affiliation":[{"name":"Colombian Association of Infectious Diseases (ACIN), Bogot\u00e1, Colombia;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","year":"2022"},{"key":"b2","year":"2021"},{"key":"b3","series-title":"Trop Med Infect Dis","first-page":"156","article-title":"Dengue infections in Colombia: Epidemiological trends of a hyperendemic country","volume":"5","author":"Gutierrez-Barbosa","year":"2020"},{"key":"b4","series-title":"PLoS Negl Trop Dis","first-page":"e0003499","article-title":"Epidemiological trends of dengue disease in Colombia (2000\u20132011): A systematic review","volume":"9","author":"Villar","year":"2015"},{"key":"b5"},{"key":"b6","series-title":"Int J Infect Dis","first-page":"458","article-title":"DENV and ZIKV detection in patients with acute febrile syndrome in C\u00f3rdoba, Colombia","volume":"99","author":"Avil\u00e9s-Vergara","year":"2020"},{"key":"b7","series-title":"Int J Infect Dis","first-page":"27","article-title":"Dengue virus serological prevalence and seroconversion rates in children and adults in Medellin, Colombia: Implications for vaccine introduction","volume":"58","author":"Carabali","year":"2017"},{"key":"b8","series-title":"Trop Med Int Health","first-page":"1231","article-title":"Burden of dengue among febrile patients at the time of chikungunya introduction in Piedecuesta, Colombia","volume":"23","author":"Carabali","year":"2018"},{"key":"b9","series-title":"BMC Infect Dis","first-page":"1","article-title":"Space and space-time distributions of dengue in a hyper-endemic urban space: The case of Girardot, Colombia","volume":"17","author":"Fuentes-Vallejo","year":"2017"},{"key":"b10","series-title":"Biomed Rev Inst Nac Salud","first-page":"133","article-title":"Clinical profile of dengue in patients consulting a tertiary hospital in the city of Cali, Colombia, 2013","volume":"36","author":"Matta","year":"2016"},{"key":"b11","series-title":"Am J Trop Med Hyg","first-page":"239","article-title":"Chikungunya, Zika, and dengue in Cali, Colombia: Preliminary results of epidemiological and geospatial analyses","volume":"95","author":"Krystosik","year":"2016"},{"key":"b12","series-title":"Int J Infect Dis IJID Off Publ Int Soc Infect Dis","first-page":"44","article-title":"A comparative study on active and passive epidemiological surveillance for dengue in five countries of Latin America","volume":"44","author":"Sarti","year":"2016"},{"key":"b13","series-title":"Value Health","first-page":"S564","article-title":"PIN121 longitudinal trends and burden of tropical infectious diseases in Colombia: A real-world DATA analysis","volume":"23","author":"Hern\u00e1ndez","year":"2020"},{"key":"b14","series-title":"Rev Panam Salud Publica Pan Am J Public Health","first-page":"e49","article-title":"Co-circulation of dengue, chikungunya, and Zika viruses in Colombia from 2008 to 2018","volume":"43","author":"Rico-Mendoza","year":"2019"},{"key":"b15","series-title":"J Med Virol","first-page":"522","article-title":"Dengue and COVID\u201019, overlapping epidemics? An analysis from Colombia","volume":"93","author":"Cardona\u2010Ospina","year":"2021"},{"key":"b16","series-title":"Lancet Infect Dis","first-page":"712","article-title":"The global burden of dengue: An analysis from the Global Burden of Disease Study 2013","volume":"16","author":"Stanaway","year":"2016"},{"key":"b17","series-title":"Vaccine","first-page":"413","article-title":"Cost-effectiveness of dengue vaccination in ten endemic countries","volume":"36","author":"Zeng","year":"2018"},{"key":"b18","series-title":"Rev Chil Infectologia Organo Of Soc Chil Infectologia","first-page":"142","article-title":"Dengue in Colombia: Ten years of database records [in Spanish]","volume":"32","author":"Castrill\u00f3n","year":"2015"},{"key":"b19","series-title":"Biom\u00e9dica","first-page":"34","article-title":"Seroprevalence of dengue infection in the municipalities of Armenia, Calarc\u00e1, La Tebaida and Montenegro in Quind\u00edo, 2014","volume":"37","author":"Jim\u00e9nez","year":"2017"},{"key":"b20","series-title":"CES Med","first-page":"93","article-title":"Factores de riesgo asociados al ingreso a unidad de cuidados intensivos en pacientes pedi\u00e1tricos hospitalizados por dengue en Cali, Colombia","volume":"34","author":"Rojas Hern\u00e1ndez","year":"2020"},{"key":"b21","series-title":"Can J Infect Dis Med Microbiol J Can Mal Infect Microbiol Medicale","first-page":"2308095","article-title":"Risk factors associated with dengue transmission and spatial distribution of high seroprevalence in schoolchildren from the urban area of Medellin, Colombia","volume":"2018","author":"Piedrahita","year":"2018"},{"key":"b22","series-title":"Am J Trop Med Hyg","first-page":"457","article-title":"Dengue endemicity and emergence of other arboviruses in Piedecuesta, Colombia","volume":"101","author":"Cardenas","year":"2019"},{"key":"b23","series-title":"Am J Trop Med Hyg","first-page":"296","article-title":"Characterization of population exposure (seroprevalence) to arboviruses after recent outbreaks in Colombia: Dengue, chikungunya and Zika","volume":"99","author":"Nouvellet","year":"2018"},{"key":"b24","series-title":"Am J Trop Med Hyg","first-page":"1422","article-title":"Factors associated with dengue virus infection and reinfection in asymptomatic children in two Colombian municipalities","volume":"99","author":"Castro-Bonilla","year":"2018"},{"key":"b25","series-title":"Int J Infect Dis IJID Off Publ Int Soc Infect Dis","first-page":"9","article-title":"Prevalence of dengue antibodies in healthy children and adults in different Colombian endemic areas","volume":"91","author":"Velandia-Romero","year":"2020"},{"key":"b26","series-title":"BMC Infect Dis","first-page":"61","article-title":"Co-circulation and simultaneous co-infection of dengue, chikungunya, and Zika viruses in patients with febrile syndrome at the Colombian-Venezuelan 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Colombia","volume":"1","author":"Poveda","year":"2000"},{"key":"b31","series-title":"Epidemiol Infect","first-page":"e77","article-title":"Dengue, chikungunya and zika virus coinfection: Results of the national surveillance during the zika epidemic in Colombia","volume":"147","author":"Mercado-Reyes","year":"2019"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/112\/1\/article-p182.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/112\/1\/article-p182.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/112\/1\/article-p182.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T08:05:07Z","timestamp":1736323507000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/112\/1\/article-p182.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,8]]},"references-count":31,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.23-0907","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,8]]}}}