{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:46:24Z","timestamp":1793213184121,"version":"4.5.0"},"reference-count":21,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,8]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Hemorrhagic fever with renal syndrome (HFRS) is caused by hantaviruses. Data of 34 patients with HFRS hospitalized at Chosun University Hospital, South Korea, between 2010 and 2021 were retrospectively analyzed. Nested reverse transcription polymerase chain reaction (RT-nPCR) targeting the L segment of hantavirus and sequencing were used for diagnosis. Most cases occurred in men and during the months of October through December. Common symptoms were fever, chills, gastrointestinal symptoms, and myalgia. The common laboratory abnormalities were thrombocytopenia, proteinuria, and elevated levels of serum creatinine, aspartate transaminase, alanine transaminase, and lactate dehydrogenase. Approximately 91.2% of patients had the Hantaan virus with a new genotype cluster, whereas 8.8% had the Seoul virus. Seropositivity based on IgM titer &gt;1:32 on admission was noted in 20.6%, and a 4-fold increase in IgG titer of 1:512 was observed in 11.8%. This study demonstrated that RT-nPCR targeting the L segment of hantaviruses is a more reliable diagnostic method compared to serological testing.<\/jats:p>","DOI":"10.4269\/ajtmh.24-0019","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T12:20:33Z","timestamp":1730290833000},"page":"161-166","source":"Crossref","is-referenced-by-count":3,"title":["Analysis of Clinical and Laboratory Profiles of Patients Hospitalized with Hemorrhagic Fever with Renal Syndrome in Southwestern South Korea"],"prefix":"10.4269","volume":"112","author":[{"given":"Ma Eum","family":"Park","sequence":"first","affiliation":[{"name":"School of Medicine, Chosun University, Dong-gu, Gwangju, South Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, Chosun University, Gwangju, South Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Won","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, Chosun University, Gwangju, South Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na Ra","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, Chosun University, Gwangju, South Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You Mi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, Chosun University, Gwangju, South Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choon Mee","family":"Kim","sequence":"additional","affiliation":[{"name":"Premedical Science, College of Medicine, Chosun University, Gwangju, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, Chosun University, Gwangju, South Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Lancet Infect Dis","first-page":"e371","article-title":"Hantavirus in humans: A review of clinical aspects and management","volume":"23","author":"Vial","year":"2023"},{"key":"b2","series-title":"Kidney Int Suppl","first-page":"S88","article-title":"Clinical features of hemorrhagic fever with renal syndrome in Korea","volume":"35","author":"Lee","year":"1991"},{"key":"b3","series-title":"Arch Pathol Lab Med","first-page":"30","article-title":"Hantaviruses. a short review","volume":"127","author":"Lednicky","year":"2003"},{"key":"b4","series-title":"Infect Chemother","first-page":"1","article-title":"Hemorrhagic fever with renal syndrome: 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syndrome","volume":"51","author":"Noh","year":"2019"},{"key":"b13","series-title":"Vaccine","first-page":"1289","article-title":"Long-term immunogenicity and safety of inactivated Hantaan virus vaccine (HantavaxTM) in healthy adults","volume":"34","author":"Song","year":"2016"},{"key":"b14","series-title":"Am J Trop Med Hyg","first-page":"1285","article-title":"Utility of nested reverse-transcriptase polymerase chain reaction of clinical specimens for early diagnosis of hemorrhagic fever with renal syndrome","volume":"105","author":"Seo","year":"2021"},{"key":"b15","series-title":"Am J Trop Med Hyg","first-page":"801","article-title":"Acute appendicitis associated with Hantaan virus infection","volume":"105","author":"Lim","year":"2021"},{"key":"b16","series-title":"BMC Infect Dis","first-page":"153","article-title":"Epidemiologic study on changes in occurrence of hemorrhagic fever with renal syndrome in Republic of Korea for 17 years according to age group: 2001\u20132017","volume":"19","author":"Park","year":"2019"},{"key":"b17","series-title":"J Korean Med Sci","first-page":"1552","article-title":"Epidemiology of hemorrhagic fever with renal syndrome in Korea, 2001-2010","volume":"28","author":"Lee","year":"2013"},{"key":"b18","series-title":"Front Microbiol","first-page":"1329683","article-title":"Epidemiological and clinical characteristics of death from hemorrhagic fever with renal syndrome: A meta-analysis","volume":"15","author":"Lu","year":"2024"},{"key":"b19","series-title":"J Infect Dis","first-page":"242","article-title":"Sin Nombre virus-specific immunoglobulin M and G kinetics in hantavirus pulmonary syndrome and the role played by serologic responses in predicting disease outcome","volume":"202","author":"MacNeil","year":"2010"},{"key":"b20","series-title":"J Virol Methods","first-page":"117","article-title":"Diagnostic rapid tests for acute hantavirus infections: Specific tests for Hantaan, Dobrava and Puumala viruses versus a hantavirus combination test","volume":"108","author":"Hujakka","year":"2003"},{"key":"b21","series-title":"Viruses","first-page":"11","article-title":"Wild rats, laboratory rats, pet rats: Global Seoul hantavirus disease revisited","volume":"11","author":"Clement","year":"2019"}],"container-title":["The American Journal of Tropical Medicine and 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