{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T05:19:54Z","timestamp":1741238394417,"version":"3.38.0"},"reference-count":19,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,5]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Fascioliasis, a food-borne trematodiasis, is a disease primarily identified in livestock, such as sheep and cattle. Human fascioliasis has been reported sporadically in Korea, but a recent increase in patients has been associated with a green vegetable juice delivery service. We aimed to investigate the serological and radiological findings of the patients treated for fascioliasis. Patients with peripheral eosinophilia, which is a positive antibody for <jats:italic>Fasciola hepatica<\/jats:italic> (<jats:italic>F. hepatica<\/jats:italic>) and liver abscess, were considered to have fascioliasis and were treated with triclabendazole at a dose of 10 mg\/kg, administered twice. A total of 21 patients diagnosed with fascioliasis were included. Patients were categorized into the early and late diagnosis groups according to the time gap between the presentation and diagnosis. A comparison of initial magnetic resonance imaging (MRI) between the two groups revealed a filling defect of the bile duct that was more commonly observed in the late diagnosis group (72.7% versus 0%; <jats:italic>P<\/jats:italic> = 0.003). Hepatic abscess lesions resolved slowly, with 14.3%, 50%, and 85.7% of patients showing complete resolution on computed tomography 6, 12, and 24 months after treatment, respectively. The mean levels of anti-<jats:italic>F. hepatica<\/jats:italic> antibodies decreased after a 6-month follow-up (mean levels, onset versus 6-month, 12-month, or 24-month follow-up; 4.36 versus 3.29, 3.17, or 2.31, respectively; all <jats:italic>P<\/jats:italic> &lt;0.01). Eosinophil counts reduced significantly 1 month after treatment and remained normal thereafter in both groups. This study suggests that MRI could be useful for diagnosing fascioliasis in a subgroup of patients and that hepatic abscesses and positive antibody results could last for several months after treatment.<\/jats:p>","DOI":"10.4269\/ajtmh.24-0162","type":"journal-article","created":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T14:50:02Z","timestamp":1735743002000},"page":"577-580","source":"Crossref","is-referenced-by-count":0,"title":["Initial Magnetic Resonance Imaging Findings in Hepatic Fascioliasis and Serological and Radiological Response After Triclabendazole Treatment"],"prefix":"10.4269","volume":"112","author":[{"given":"Eun Jeong","family":"Won","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung-Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eui-Jin","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seongman","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiwon","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Pil","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Oh","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang-Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Han","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Jae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"J Egypt Soc Parasitol","first-page":"317","article-title":"A review on fascioliasis in Egypt","volume":"32","author":"Haseeb","year":"2002"},{"key":"b2","series-title":"Korean J Vet Serv","first-page":"1","article-title":"Studies on the optimal time for therapy of Fasciola spp. infected cattle in central area of Korea","volume":"15","author":"Sohn","year":"1992"},{"key":"b3","series-title":"J Korean Vet Med Assoc","first-page":"806","article-title":"Current status and plan of the fascioliasis in cattle","volume":"39","author":"Sohn","year":"2000"},{"key":"b4","series-title":"Korean J Hepatol","first-page":"169","article-title":"Four cases of hepatic fascioliasis mimicking cholangiocarcinoma","volume":"11","author":"Kim","year":"2005"},{"year":"2007","key":"b5"},{"key":"b6","series-title":"Am J Trop Med Hyg","first-page":"532","article-title":"Treatment of human chronic fascioliasis with triclabendazole: Drug efficacy and serologic response","volume":"52","author":"Apt","year":"1995"},{"key":"b7","series-title":"One Health","first-page":"100441","article-title":"Green vegetable juice as a potential source of human fascioliasis in Korea","volume":"15","author":"Choi","year":"2022"},{"key":"b8","series-title":"J Korean Med Sci","first-page":"1118","article-title":"Significance of serology by multi-antigen ELISA for tissue helminthiases in Korea","volume":"32","author":"Jin","year":"2017"},{"key":"b9","series-title":"Eur Radiol","first-page":"923","article-title":"Reporting standards for primary sclerosing cholangitis using MRI and MR cholangiopancreatography: Guidelines from MR Working Group of the International Primary Sclerosing Cholangitis Study Group","volume":"32","author":"Venkatesh","year":"2022"},{"key":"b10","series-title":"Curr Opin Infect Dis","first-page":"523","article-title":"Update on hepatobiliary flukes: Fascioliasis, opisthorchiasis and clonorchiasis","volume":"21","author":"Marcos","year":"2008"},{"key":"b11","series-title":"Epidemiol Infect","first-page":"669","article-title":"Endemic human fasciolosis in the Bolivian Altiplano","volume":"135","author":"Parkinson","year":"2007"},{"key":"b12","series-title":"World J Gastroenterol","first-page":"4899","article-title":"Clinical presentation and management of Fasciola hepatica infection: Single-center experience","volume":"17","author":"Kaya","year":"2011"},{"key":"b13","series-title":"Clin Microbiol Infect","first-page":"859","article-title":"Infection with Fasciola hepatica","volume":"11","author":"Aksoy","year":"2005"},{"key":"b14","series-title":"Parasitology","first-page":"1918","article-title":"Diagnosis of human fascioliasis by stool and blood techniques: Update for the present global scenario","volume":"141","author":"Mas-Coma","year":"2014"},{"key":"b15","series-title":"J Infect Dis","first-page":"1339","article-title":"Successful treatment of severe infection with Fasciola hepatica with praziquantel","volume":"152","author":"Schiappacasse","year":"1985"},{"key":"b16","series-title":"J Clin Imaging Sci","first-page":"2","article-title":"Radiological imaging features of Fasciola hepatica infection \u2013 A pictorial review","volume":"2","author":"Dusak","year":"2012"},{"key":"b17","series-title":"Trop Med Int Health","first-page":"774","article-title":"Fascioliasis: Sonographic abnormalities of the biliary tract and evolution after treatment with triclabendazole","volume":"4","author":"Richter","year":"1999"},{"key":"b18","series-title":"Korean J Parasitol","first-page":"193","article-title":"A case of Fasciola hepatica infection mimicking cholangiocarcinoma and ITS-1 sequencing of the worm","volume":"52","author":"Kang","year":"2014"},{"key":"b19","series-title":"Am J Trop Med Hyg","first-page":"350","article-title":"The antigens of Paragonimus westermani, Schistosoma mansoni, and Fasciola hepatica adult worms. Evidence for the presence of cross-reactive antigens and for cross-protection to Schistosoma mansoni infection using antigens of Paragonimus westermani","volume":"32","author":"Hillyer","year":"1983"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/112\/3\/article-p577.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/112\/3\/article-p577.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/112\/3\/article-p577.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T14:33:54Z","timestamp":1741185234000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/112\/3\/article-p577.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,5]]},"references-count":19,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.24-0162","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"type":"print","value":"0002-9637"},{"type":"electronic","value":"1476-1645"}],"subject":[],"published":{"date-parts":[[2025,3,5]]}}}