{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T07:40:05Z","timestamp":1793173205056,"version":"4.5.0"},"reference-count":0,"publisher":"American Society of Tropical Medicine and Hygiene","license":[{"start":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T00:00:00Z","timestamp":1723507200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,13]]},"abstract":"<jats:p>Typbar-TCV<jats:sup>\u00ae<\/jats:sup>, a typhoid conjugate vaccine (TCV), was prequalified by the World Health Organization in 2017. We evaluated its effectiveness in a mass vaccination program targeting children 9 months to 14\u2009years in Navi Mumbai, India, from September 2018 to July 2020. We compared laboratory-confirmed typhoid cases from six clinical sites with age-matched community controls. Of 38 cases, three (8.6%) received TCV through the campaign, compared with 53 (37%) of 140 controls. The adjusted odds ratio of typhoid fever among vaccinated children was 0.16 (95% CI: 0.05\u20130.55), equivalent to a vaccine effectiveness of 83.7% (95% CI: 45.0\u201395.3). Vaccine effectiveness of Typbar-TCV in this large public sector vaccine introduction was similar to prior randomized controlled trials, providing reassurance to policymakers that TCV effectiveness is robust in a large-scale implementation.<\/jats:p>","DOI":"10.4269\/ajtmh.24-0181","type":"journal-article","created":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T13:24:43Z","timestamp":1723555483000},"source":"Crossref","is-referenced-by-count":3,"title":["Field Effectiveness of a Typhoid Conjugate Vaccine: The 2018 Navi Mumbai Pediatric TCV Campaign"],"prefix":"10.4269","author":[{"given":"Kashmira","family":"Date","sequence":"first","affiliation":[{"name":"Global Immunization Division, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"LeBoa","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seth A.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Haldar","sequence":"additional","affiliation":[{"name":"Ministry of Health & Family Welfare, Government of India, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Harvey","sequence":"additional","affiliation":[{"name":"World Health Organization-Country Office for India, National Public Health Surveillance Project, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"An","sequence":"additional","affiliation":[{"name":"Global Immunization Division, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenhua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Global Immunization Division, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay N.","family":"Yewale","sequence":"additional","affiliation":[{"name":"Dr. Yewale Multispecialty Hospital for Children, Navi Mumbai, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savita","family":"Daruwalla","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, NMMC General Hospital, Navi Mumbai, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhanya","family":"Dharmapalan","sequence":"additional","affiliation":[{"name":"Dr. Yewale Multispecialty Hospital for Children, Navi Mumbai, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeetendra","family":"Gavhane","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, MGM New Bombay Hospital, MGM Medical College, Navi Mumbai, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrikrishna","family":"Joshi","sequence":"additional","affiliation":[{"name":"Dr. Joshi\u2019s Central Clinical Microbiology Laboratory, Navi Mumbai, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Rai","sequence":"additional","affiliation":[{"name":"Department of Pediatrics & Neonatology, Dr. D.Y. Patil Medical College and Hospital, Navi Mumbai, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha","family":"Rathod","sequence":"additional","affiliation":[{"name":"Rajmata Jijau Hospital, Airoli (NMMC), Navi Mumbai, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keertana","family":"Shetty","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Dr. D.Y. Patil Medical College and Hospital, Navi Mumbai, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divyalatha S.","family":"Warrier","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Mathadi Trust Hospital, Navi Mumbai, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Microbiology, MGM New Bombay Hospital, Navi Mumbai, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Shimpi","sequence":"additional","affiliation":[{"name":"World Health Organization-Country Office for India, National Public Health Surveillance Project, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niniya","family":"Jayaprasad","sequence":"additional","affiliation":[{"name":"World Health Organization-Country Office for India, National Public Health Surveillance Project, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily","family":"Horng","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Fagerli","sequence":"additional","affiliation":[{"name":"Global Immunization Division, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Borhade","sequence":"additional","affiliation":[{"name":"World Health Organization-Country Office for India, National Public Health Surveillance Project, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debjit","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"National Institute of Cholera and Enteric Diseases, Indian Council of Medical Research, Kolkata, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Katkar","sequence":"additional","affiliation":[{"name":"World Health Organization-Country Office for India, National Public Health Surveillance Project, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Kunwar","sequence":"additional","affiliation":[{"name":"World Health Organization-Country Office for India, National Public Health Surveillance Project, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason R.","family":"Andrews","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Bahl","sequence":"additional","affiliation":[{"name":"World Health 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