{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:05:30Z","timestamp":1793142330427,"version":"4.5.0"},"reference-count":37,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>Twelve-month mortality in sepsis survivors has not been previously characterized in sub-Saharan Africa. Hospitalized adults with \u22652 modified systemic inflammatory response syndrome criteria (temperature &lt;36\u00b0C or &gt;38\u00b0C, heart rate \u226590 beats per minute, or respiratory rate \u226520 breaths per minute) were enrolled at a tertiary care center from October 2017 to August 2022. Multiple clinical blood and respiratory molecular and antigen assays were used to identify infectious etiologies. Baseline demographics were evaluated for risk of death by 1 month and 12 months using Cox proportional hazards regression. Among 435 participants, the median age was 42.0 years (interquartile range: 28.0\u201357.0 years), 59.1% were female, and 31.7% were living with HIV. Malaria (17.2%), followed by tuberculosis (4.6%) and bacteremia (4.6%), were the most common detected causes of illness. Overall, 49 (11.3%) participants died, and 24 participants died within 1 month to 1 year (49.0% of deaths). Female participants had a decreased risk of death by 12 months (unadjusted hazard ratio: 0.38; 95% CI: 0.21\u20130.68). The mortality of sepsis may be underestimated in sub-Saharan Africa because nearly half of deaths occurred after the first month, underscoring the need for long-term follow-up.<\/jats:p>","DOI":"10.4269\/ajtmh.24-0212","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:24:03Z","timestamp":1783009443000},"page":"616-624","source":"Crossref","is-referenced-by-count":1,"title":["Long-Term Mortality among Hospitalized Adults with Sepsis in Uganda: A Prospective Cohort Study"],"prefix":"10.4269","volume":"115","author":[{"given":"Abdullah","family":"Wailagala","sequence":"first","affiliation":[{"name":"Infectious Diseases Institute, Makerere University, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Okello","sequence":"additional","affiliation":[{"name":"Makerere University Walter Reed Program, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willy","family":"Kayondo","sequence":"additional","affiliation":[{"name":"Makerere University Walter Reed Program, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodgers R.","family":"Ayebare","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, Makerere University, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David F.","family":"Olebo","sequence":"additional","affiliation":[{"name":"Makerere University Walter Reed Program, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mubaraka","family":"Kayiira","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, Makerere University, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Gregory","sequence":"additional","affiliation":[{"name":"Leidos Biomedical Research, Frederick, Maryland, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy M.","family":"Kemigisha","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, Makerere University, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff W.","family":"Koehler","sequence":"additional","affiliation":[{"name":"U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randal J.","family":"Schoepp","sequence":"additional","affiliation":[{"name":"U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Badu","sequence":"additional","affiliation":[{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehkonti","family":"Adams","sequence":"additional","affiliation":[{"name":"Naval Medical Research Center Infectious Diseases Directorate, Silver Spring, Maryland, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prossy","family":"Naluyima","sequence":"additional","affiliation":[{"name":"Makerere University Walter Reed Program, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charmagne","family":"Beckett","sequence":"additional","affiliation":[{"name":"Naval Medical Research Center Infectious Diseases Directorate, Silver Spring, Maryland, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Lamorde","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, Makerere University, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Waitt","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, Makerere University, Kampala, Uganda;"},{"name":"School of Medicine, University of Liverpool, Liverpool, UK;"},{"name":"Wirral University Teaching Hospital NHS Foundation Trust, Upton, UK;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Kibuuka","sequence":"additional","affiliation":[{"name":"Makerere University Walter Reed Program, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle V.","family":"Clark","sequence":"additional","affiliation":[{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.","family":"Blair","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Lancet","first-page":"200","article-title":"Global, regional, and national sepsis incidence and mortality, 1990\u20132017: Analysis for the Global Burden of Disease Study","volume":"395","author":"Rudd","year":"2020"},{"key":"b2","series-title":"Front Immunol","first-page":"605666","article-title":"Why septic patients remain sick after hospital discharge?","volume":"11","author":"Gritte","year":"2020"},{"key":"b3","series-title":"Clin Infect Dis","first-page":"1840","article-title":"A longitudinal observational study of aetiology and long-term outcomes of 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