{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T15:07:38Z","timestamp":1784214458960,"version":"3.55.0"},"reference-count":56,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,8]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Over the last 20\u2009years, the U.S. President\u2019s Emergency Plan for AIDS Relief (PEPFAR) has rapidly expanded and made remarkable progress toward the UNAIDS 95-95-95 targets to end the HIV epidemic. Nevertheless, HIV continues to pose a significant health challenge globally, with a particular impact on the African continent. Funded by PEPFAR, the African Cohort Study (AFRICOS) has served as a monitoring and evaluation tool for PEPFAR to help guide HIV policy and PEPFAR programming for the last 10\u2009years since its inception and offers a compelling example of how PEPFAR\u2019s investment in science continues to reap dividends. This paper details and critically reviews the transformative research AFRICOS has had on helping to end the HIV epidemic as a public health threat by 2030.<\/jats:p>","DOI":"10.4269\/ajtmh.24-0249","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T21:23:55Z","timestamp":1730237035000},"page":"45-55","source":"Crossref","is-referenced-by-count":7,"title":["The Transformative Impact of the African Cohort Study (AFRICOS) Toward Reaching HIV 95-95-95 Goals in Sub-Saharan Africa"],"prefix":"10.4269","volume":"112","author":[{"given":"Neha","family":"Shah","sequence":"first","affiliation":[{"name":"U.S. Military HIV Research Program, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor A.","family":"Crowell","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland;"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaclyn","family":"Hern","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland;"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Anyebe","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program, Walter Reed Army Institute of Research Africa, Abuja, Nigeria;"},{"name":"Henry Jackson Foundation Medical Research International, Abuja, Nigeria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Bahemana","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program, Walter Reed Army Institute of Research Africa, Mbeya, Tanzania;"},{"name":"HJF Medical Research International, Mbeya, Tanzania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Kibuuka","sequence":"additional","affiliation":[{"name":"Makerere University Walter Reed Project, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentine","family":"Singoei","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Walter Reed Army Institute of Research Africa, Kisumu, Kenya;"},{"name":"HJF Medical Research International, Kisumu, Kenya;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonah","family":"Maswai","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Walter Reed Army Institute of Research Africa, Kericho, Kenya;"},{"name":"HJF Medical Research International, Kericho, Kenya;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Parikh","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland;"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma R.","family":"Duff","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland;"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph Sean","family":"Cavanaugh","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew L.","family":"Romo","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland;"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Ake","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J. A.","family":"Reid","sequence":"additional","affiliation":[{"name":"Bureau of Global Health Security and Diplomacy, President\u2019s Emergency Plan for AIDS Relief, Washington, District of Columbia;"},{"name":"Institute of Global Health Sciences, University of California at San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AMB John N.","family":"Nkengasong","sequence":"additional","affiliation":[{"name":"Bureau of Global Health Security and Diplomacy, President\u2019s Emergency Plan for AIDS Relief, Washington, District of Columbia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"_","family":"_","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"The Path That Ends AIDS: UNAIDS Global AIDS Update 2023","year":"2023"},{"key":"b2","series-title":"JAMA","first-page":"219","article-title":"PEPFAR at 20\u2012Looking back 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