{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T05:24:43Z","timestamp":1736400283384,"version":"3.32.0"},"reference-count":62,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,8]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Malaria in child travelers caused by <jats:italic>Plasmodium ovale<\/jats:italic> spp. is less well characterized than malaria due to other <jats:italic>Plasmodium<\/jats:italic> species. Commonly used diagnostic tests often lack adequate sensitivity to identify <jats:italic>P. ovale<\/jats:italic> spp., and a missed diagnosis may have serious consequences. We present a case series of eight children in the United States with <jats:italic>P. ovale<\/jats:italic> malaria, all of whom had traveled to or immigrated from malaria-endemic areas. Two children developed clinical malaria, including one with severe malaria; two had isolated splenomegaly; and four were asymptomatic siblings of the children with splenomegaly. Seven of the eight children had negative blood smear readings, and the diagnosis was made by polymerase chain reaction testing. Two children had concurrent <jats:italic>P. malariae<\/jats:italic> infection despite presumptive antimalarial treatment before immigration. These findings suggest a need for reconsideration of screening and diagnostic evaluation for <jats:italic>P. ovale<\/jats:italic> malaria in high-risk groups.<\/jats:p>","DOI":"10.4269\/ajtmh.24-0333","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T11:43:42Z","timestamp":1729683822000},"page":"66-71","source":"Crossref","is-referenced-by-count":0,"title":["Plasmodium ovale Malaria in Travelers and Immigrants to the United States: A Case Series"],"prefix":"10.4269","volume":"112","author":[{"given":"Jonathan A.","family":"Mayhew","sequence":"first","affiliation":[{"name":"Ryan White Center for Global Health and Pediatric Infectious Diseases, Indiana University, Indianapolis, Indiana;"},{"name":"Department of Pediatric & Adolescent Medicine, Western Michigan University School of Medicine, Kalamazoo, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muayad","family":"Alali","sequence":"additional","affiliation":[{"name":"Ryan White Center for Global Health and Pediatric Infectious Diseases, Indiana University, Indianapolis, Indiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie A.","family":"Enane","sequence":"additional","affiliation":[{"name":"Ryan White Center for Global Health and Pediatric Infectious Diseases, Indiana University, Indianapolis, Indiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsey M.","family":"Kirkpatrick","sequence":"additional","affiliation":[{"name":"Ryan White Center for Global Health and Pediatric Infectious Diseases, Indiana University, Indianapolis, Indiana;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandy C.","family":"John","sequence":"additional","affiliation":[{"name":"Ryan White Center for Global Health and Pediatric Infectious Diseases, Indiana University, Indianapolis, 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