{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T17:37:42Z","timestamp":1785173862545,"version":"3.55.0"},"reference-count":23,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4_Suppl","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Finding additional ways to manage lymphedema due to lymphatic filariasis (LF) is a primary concern for the Global Program to Eliminate Lymphatic Filariasis. The WHO-recommended Essential Package of Care (EPC) consists of skin hygiene, elevation of affected limbs, exercise, protective shoe ware, wound care, and supportive therapy for acute phases. The care program has been successful but often hard to maintain. A double-blind study reexamined previous findings that doxycycline treatment could improve the lymphedematous changes in LF patients. The present study was carried out in a semi-urban location of Kerala, southern India, where <jats:italic>Brugia<\/jats:italic> sp. is the predominant parasite, and LF mass drug administration had ceased in many areas. Two hundred individuals (aged 14\u201365\u2009years; 142 females and 58 males) with lymphedema of stages 1\u20133 were instructed in the EPC and were randomly administered either 200\u2009mg doxycycline or an identical-appearing placebo daily for 6\u2009weeks. Data were collected at 0, 3, 6, 12, 18, and 24 months and included the state of the lymphedema (size, cleanliness, skin thickness and changes), occurrence of adenolymphangitis (ADL) attacks, and patients\u2019 quality of life (QOL). The results demonstrated no difference over time between the two arms of the study; virtually all patients of both groups showed either improvement or \u201cno worsening\u201d in the parameters during the 2-year study period. Importantly, this rigorous trial confirmed that the EPC is of substantial benefit to lymphedema patients by reducing acute ADL and improving their QOL and clinical condition.<\/jats:p>","DOI":"10.4269\/ajtmh.24-0337","type":"journal-article","created":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T12:35:43Z","timestamp":1727872543000},"page":"83-93","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and Safety of Adding 6 Weeks of Doxycycline to the Essential Package of Care to Treat Filarial Lymphedema: A Double-Blind, Randomized, Controlled Trial in Southern India"],"prefix":"10.4269","volume":"111","author":[{"given":"Suma","family":"Krishnasastry","sequence":"first","affiliation":[{"name":"WHO Collaborating Centre for Lymphatic Filariasis Morbidity Management and Disability Prevention, Government TD Medical College, Alappuzha, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuja","family":"Ashok","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Lymphatic Filariasis Morbidity Management and Disability Prevention, Government TD Medical College, Alappuzha, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammu","family":"Devidas","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Lymphatic Filariasis Morbidity Management and Disability Prevention, Government TD Medical College, Alappuzha, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Neglected Tropical Disease-Supporting Centre (NTD-SC), Task Force for Global Health, Decatur, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Stephens","sequence":"additional","affiliation":[{"name":"Neglected Tropical Disease-Supporting Centre (NTD-SC), Task Force for Global Health, Decatur, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayla","family":"Norman","sequence":"additional","affiliation":[{"name":"Neglected Tropical Disease-Supporting Centre (NTD-SC), Task Force for Global Health, Decatur, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elianna","family":"Paljug","sequence":"additional","affiliation":[{"name":"Neglected Tropical Disease-Supporting Centre (NTD-SC), Task Force for Global Health, Decatur, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Deathe","sequence":"additional","affiliation":[{"name":"Neglected Tropical Disease-Supporting Centre (NTD-SC), Task Force for Global Health, Decatur, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Majewski","sequence":"additional","affiliation":[{"name":"Neglected Tropical Disease-Supporting Centre (NTD-SC), Task Force for Global Health, Decatur, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Horton","sequence":"additional","affiliation":[{"name":"Tropical Projects, Hitchin, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph P.","family":"Shott","sequence":"additional","affiliation":[{"name":"Division of Neglected Tropical Diseases, Office of Infectious Diseases, Global Health Bureau, US Agency for International Development, Washington, District of Columbia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute","family":"Klarmann-Schultz","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, Immunology and Parasitology, German Centre for Infection Research (DZIF), University Hospital Bonn, Bonn, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim","family":"Hoerauf","sequence":"additional","affiliation":[{"name":"Institute for Medical Microbiology, Immunology and Parasitology, German Centre for Infection Research (DZIF), University Hospital Bonn, Bonn, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Ottesen","sequence":"additional","affiliation":[{"name":"Neglected Tropical Disease-Supporting Centre (NTD-SC), Task Force for Global Health, Decatur, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles D.","family":"Mackenzie","sequence":"additional","affiliation":[{"name":"Neglected Tropical Disease-Supporting Centre (NTD-SC), Task Force for Global Health, Decatur, Georgia;"},{"name":"Reaching the Last Mile Fund (RLMF), The Ending Neglected tropical Diseases (END) Fund, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Int Health","first-page":"S48","article-title":"Caring for patients in the global programme to eliminate lymphatic 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