{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T21:09:34Z","timestamp":1776114574711,"version":"3.50.1"},"reference-count":10,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,8]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Enteric fever is an endemic disease in developing and low-middle income countries due to poor sanitation and hygiene. The majority of cases have mild symptoms and resolve with oral or intravenous antibiotics. However, multisystemic involvement due to enteric fever requiring intensive care is not uncommon and is associated with high mortality and morbidity. We report a 5-year-old boy from Mohali, Punjab, India with enteric fever who had fulminant course with several complications including transient intussusception, myocardial dysfunction, encephalopathy, and secondary hemophagocytic lymphohistiocytosis. He was treated with ceftriaxone, vasoactive drugs, mechanical ventilation, dexamethasone, and intravenous immunoglobulin and had favorable outcome despite life-threatening complications.<\/jats:p>","DOI":"10.4269\/ajtmh.24-0385","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T15:57:44Z","timestamp":1729007864000},"page":"111-112","source":"Crossref","is-referenced-by-count":1,"title":["Enteric Fever with Intussusception, Myocardial Dysfunction, Encephalopathy, and Hemophagocytic Lymphohistiocytosis in an Indian Child"],"prefix":"10.4269","volume":"112","author":[{"given":"Puspraj","family":"Awasthi","sequence":"first","affiliation":[{"name":"Division of Pediatric Critical Care, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh Kumar","family":"Angurana","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karthi","family":"Nallasamy","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun","family":"Bansal","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"J Infect Dis","first-page":"S469","article-title":"Typhoid in India: An age-old problem with an existing solution","volume":"224","author":"Kumar","year":"2021"},{"key":"b2","series-title":"PLoS Negl Trop Dis","first-page":"e0004616","article-title":"The burden of typhoid and paratyphoid in India: Systematic review and meta-analysis","volume":"10","author":"John","year":"2016"},{"key":"b3","series-title":"Pediatr Infect Dis J","first-page":"e27","article-title":"A tale of complicated enteric fever: Common disease with unusual complications","volume":"43","author":"Mylavarapu","year":"2024"},{"key":"b4","series-title":"N Engl J Med","first-page":"1491","article-title":"Burden of typhoid and paratyphoid fever in India","volume":"388","author":"John","year":"2023"},{"key":"b5","series-title":"Pediatr Crit Care Med","first-page":"e44","article-title":"Hemophagocytic lymphohistiocytosis in a PICU of a developing economy: Clinical profile, intensive care needs, outcome, and predictors of mortality","volume":"22","author":"Parajuli","year":"2021"},{"key":"b6","series-title":"Open Forum Infect Dis","first-page":"S67","article-title":"Characterization of typhoid intestinal perforation in Africa: Results from the severe typhoid fever surveillance in Africa","volume":"10","author":"Birkhold","year":"2023"},{"key":"b7","series-title":"Am J Trop Med Hyg","first-page":"82","article-title":"Outbreak of typhoid fever in children of urban Vellore: A report from the Surveillance for Enteric Fever in India cohort","volume":"107","author":"Srinivasan","year":"2022"},{"key":"b8","series-title":"Pediatr Infect Dis J","first-page":"e49","article-title":"High-dose dexamethasone in a child with enteric encephalopathy caused by Salmonella enterica serovar Typhi","volume":"39","author":"Laps","year":"2020"},{"key":"b9","series-title":"Cureus","first-page":"e5049","article-title":"From gut to heart: Havoc in a young patient with typhoid-associated cardiomyopathy","volume":"11","author":"Majid","year":"2019"},{"key":"b10","series-title":"Am J Trop Med Hyg","first-page":"1098","article-title":"Cardiac involvement in travelers with enteric fever","volume":"100","author":"Biber","year":"2019"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/112\/1\/article-p111.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/112\/1\/article-p111.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/112\/1\/article-p111.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T13:05:56Z","timestamp":1736341556000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/112\/1\/article-p111.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,8]]},"references-count":10,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.24-0385","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,8]]}}}