{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T13:27:33Z","timestamp":1792848453697,"version":"4.5.0"},"reference-count":33,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,5]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Dengue virus (DENV) is the most common arbovirus globally, with its incidence growing dramatically in recent decades. Although the effects of DENV infection during pregnancy are unclear, reported associations with adverse health outcomes include miscarriage, prematurity, and low birth weight. In this study, we used an IgG ELISA to identify mothers exposed to DENV during pregnancy by testing samples obtained from a previous study that followed a cohort of pregnant women in Kenya to investigate parasitic infections during pregnancy. We compared adverse pregnancy and infant health outcomes between seronegative mothers and those who seroconverted. Of the 289 participants tested for DENV exposure during pregnancy, we estimated that \u223c12 women (4%) would have been exposed to DENV during their gestation period. However, we found that 34 mothers (11.8%) had been exposed to DENV during pregnancy. None of these mothers were hospitalized during pregnancy because of severe DENV infection, suggesting that many may have undergone asymptomatic seroconversion. The demographic risk factors of socioeconomic status, education level, bed net use, and maternal age were not associated with mild or asymptomatic DENV in pregnancy. Although mild or asymptomatic DENV during pregnancy was not associated with late prematurity, reduced postnatal childhood developmental measures, or adverse maternal pregnancy outcomes, we observed an increased risk of low birth weight. The larger-than-expected burden of DENV in pregnancy in this coastal Kenyan cohort and the observed potential risk of low birth weight provide evidence that a more comprehensive study is warranted to fully understand DENV infection during pregnancy.<\/jats:p>","DOI":"10.4269\/ajtmh.24-0387","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T20:35:12Z","timestamp":1733258112000},"page":"396-402","source":"Crossref","is-referenced-by-count":8,"title":["Exposure to Dengue Virus During Pregnancy: Incidence and Impact on Maternal and Child Outcomes"],"prefix":"10.4269","volume":"112","author":[{"given":"Annabelle","family":"Smith","sequence":"first","affiliation":[{"name":"Stanford Medicine, Stanford University, Stanford, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethel Alebel","family":"Bayrau","sequence":"additional","affiliation":[{"name":"Stanford Medicine, Stanford University, Stanford, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Ichura","sequence":"additional","affiliation":[{"name":"Stanford Medicine, Stanford University, Stanford, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Altamirano","sequence":"additional","affiliation":[{"name":"Stanford Medicine, Stanford University, Stanford, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"King","sequence":"additional","affiliation":[{"name":"Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indu","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Mungai","sequence":"additional","affiliation":[{"name":"Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Mutuku","sequence":"additional","affiliation":[{"name":"Department of Environment and Health Sciences, Technical University of Mombasa, Mombasa, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dunstan","family":"Mukoko","sequence":"additional","affiliation":[{"name":"Department of Environment and Health Sciences, Technical University of Mombasa, Mombasa, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. D\u00e9sir\u00e9e","family":"LaBeaud","sequence":"additional","affiliation":[{"name":"Stanford Medicine, Stanford University, Stanford, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Dengue Areas of Risk around the World","year":"2023"},{"key":"b2","series-title":"J Travel Med","first-page":"taae069","article-title":"Discrepancies in dengue burden estimates: A comparative analysis of reported cases and global burden of disease study, 2010\u20132019","volume":"31","author":"Lee","year":"2024"},{"key":"b3","series-title":"Dengue and Severe Dengue","year":"2024"},{"key":"b4","series-title":"Clin Med (Lond)","first-page":"9","article-title":"Dengue infection: Global importance, immunopathology and management","volume":"22","author":"Kularatne","year":"2022"},{"key":"b5","series-title":"Lancet Planet Health","first-page":"e416","article-title":"Climate change could shift disease burden from malaria to arboviruses in Africa","volume":"4","author":"Mordecai","year":"2020"},{"key":"b6","series-title":"J Travel Med","first-page":"taz077","article-title":"Dengue, Zika and chikungunya during pregnancy: Pre- and post-travel advice and clinical management","volume":"26","author":"Vouga","year":"2019"},{"key":"b7","series-title":"Arch Gynecol Obstet","first-page":"91","article-title":"Maternal and fetal outcomes of dengue fever in pregnancy: A large prospective and descriptive observational study","volume":"304","author":"Brar","year":"2021"},{"key":"b8","series-title":"Nagoya J Med Sci","first-page":"241","article-title":"Dengue fever during pregnancy","volume":"80","author":"Trinh","year":"2018"},{"key":"b9","series-title":"Eur J Obstet Gynecol Reprod Biol","first-page":"205","article-title":"Dengue in pregnancy: Review article","volume":"261","author":"Varsha","year":"2021"},{"key":"b10","series-title":"Med J Armed Forces India","first-page":"90","article-title":"Seroprevalence of dengue infection in pregnant women and placental antibody transfer","volume":"75","author":"Nujum","year":"2019"},{"key":"b11","series-title":"Lancet Infect Dis","first-page":"857","article-title":"Dengue during pregnancy and adverse fetal outcomes: A systematic review and meta-analysis","volume":"16","author":"Paix\u00e3o","year":"2016"},{"key":"b12","series-title":"Trop Med Int Health","first-page":"619","article-title":"Maternal and foetal-neonatal outcomes of dengue virus infection during pregnancy","volume":"27","author":"Rathore","year":"2022"},{"key":"b13","series-title":"Viral Immunol","first-page":"48","article-title":"Seroprevalence of dengue virus among pregnant women in Guangdong, China","volume":"33","author":"Liu","year":"2020"},{"key":"b14","series-title":"J Clin Virol","first-page":"105616","article-title":"Arbovirus surveillance in pregnant women in north-central Nigeria, 2019\u20132022","volume":"169","author":"Ogwuche","year":"2023"},{"key":"b15","series-title":"J Pediatr","first-page":"1514","article-title":"Perinatal transmission of dengue: A report of 7 cases","volume":"163","author":"Ribeiro","year":"2013"},{"key":"b16","series-title":"J Clin Virol","first-page":"42","article-title":"Dengue virus infection during pregnancy increased the risk of adverse fetal outcomes? 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