{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:45:01Z","timestamp":1791377101620,"version":"4.3.2"},"reference-count":7,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,8]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>With the rise in total joint arthroplasties, prosthetic joint infections (PJIs) have become a significant complication, leading to high morbidity. The causative organisms of PJIs vary by region, and the rates of drug-resistant organisms are growing, thus complicating the initial empiric choice of antibiotics. This retrospective study analyzed records of patients with orthopedic implants and intraoperative tissue samples sent for sonication and culture at a tertiary care hospital in India. The most common organism was <jats:italic>Staphylococcus aureus<\/jats:italic> (14 out of 86 bacterial isolates, 16.3%), followed by <jats:italic>Pseudomonas aeruginosa<\/jats:italic> (12 out of 86, 13.9%), and both <jats:italic>Staphylococcus epidermidis<\/jats:italic> and <jats:italic>Klebsiella pneumoniae<\/jats:italic> (11 each out of 86, 12.8%). There was a high prevalence of multidrug-resistant organisms, and 35% of the gram-negative organisms were carbapenem resistant. Our study reveals that in our setting, PJIs are chiefly driven by multidrug resistant gram-negative bacteria.<\/jats:p>","DOI":"10.4269\/ajtmh.24-0396","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T21:23:52Z","timestamp":1730237032000},"page":"113-115","source":"Crossref","is-referenced-by-count":3,"title":["Microbiological Profile of Periprosthetic Joint Infections: A Retrospective Analysis from North India"],"prefix":"10.4269","volume":"112","author":[{"given":"Souradeep","family":"Chowdhury","sequence":"first","affiliation":[{"name":"Department of Medicine and Microbiology, All India Institute of Medical Sciences, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunit","family":"Sikdar","sequence":"additional","affiliation":[{"name":"Department of Medicine and Microbiology, All India Institute of Medical Sciences, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, All India Institute of Medical Sciences, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benu","family":"Dhawan","sequence":"additional","affiliation":[{"name":"Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Clin Microbiol Rev","first-page":"302","article-title":"Prosthetic joint infection","volume":"27","author":"Tande","year":"2014"},{"key":"b2","series-title":"Skeletal Radiol","first-page":"847","article-title":"Prosthetic joint infections: Diagnosis, management, and complications of the two-stage replacement arthroplasty","volume":"49","author":"Porrino","year":"2020"},{"key":"b3","series-title":"J Bone Joint Surg Am","first-page":"869","article-title":"Diagnosis of periprosthetic infection","volume":"88","author":"Bauer","year":"2006"},{"key":"b4","series-title":"J Arthroplasty","first-page":"1309","article-title":"The 2018 definition of periprosthetic hip and knee infection: An evidence-based and validated criteria","volume":"33","author":"Parvizi","year":"2018"},{"key":"b5","series-title":"Indian J Orthop","first-page":"646","article-title":"A clinico-microbiological study of prosthetic joint infections in an Indian tertiary care hospital: Role of universal 16S rRNA gene polymerase chain reaction and sequencing in diagnosis","volume":"53","author":"Sebastian","year":"2019"},{"key":"b6","series-title":"Clin Orthop Relat Res","first-page":"1710","article-title":"Periprosthetic joint infection: The incidence, timing, and predisposing factors","volume":"466","author":"Pulido","year":"2008"},{"key":"b7","series-title":"N Engl J Med","first-page":"251","article-title":"Periprosthetic joint infection","volume":"388","author":"Patel","year":"2023"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/112\/1\/article-p113.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/112\/1\/article-p113.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/112\/1\/article-p113.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T13:05:43Z","timestamp":1736341543000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/112\/1\/article-p113.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,8]]},"references-count":7,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.24-0396","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,8]]}}}