{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:42:54Z","timestamp":1768869774556,"version":"3.49.0"},"reference-count":20,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,2]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>We report two cases of recurrent malaria in U.S. travelers returning from Africa (Ghana and Central African Republic) despite a full course of artemether\u2013lumefantrine (AL). Both patients presented to New York City hospitals, received AL treatment, and clinically improved. Within 2 weeks, they presented with recurrent <jats:italic>Plasmodium falciparum<\/jats:italic> malaria. Parasite isolates were sequenced, and <jats:italic>P. falciparum kelch 13<\/jats:italic> propeller domain mutations that are validated or candidate markers of artemisinin partial resistance were not identified. Parasites had mutations within the <jats:italic>P. falciparum multidrug resistance protein 1<\/jats:italic> gene. It is crucial to remain vigilant for recurrent malaria in travelers, even from African regions where partial resistance to artemisinin-based combination therapy has only rarely been reported.<\/jats:p>","DOI":"10.4269\/ajtmh.24-0397","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T14:51:15Z","timestamp":1736261475000},"page":"771-774","source":"Crossref","is-referenced-by-count":1,"title":["Recurrent Plasmodium falciparum Malaria in U.S. Travelers Treated with Artemether\u2013Lumefantrine"],"prefix":"10.4269","volume":"112","author":[{"given":"Hendrik","family":"Sy","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Montefiore Medical Center\/Albert Einstein College of Medicine, New York, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharan","family":"Yadav","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Weill Cornell Medicine, New York, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Yangga","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Montefiore Medical Center\/Albert Einstein College of Medicine, New York, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Shaffer","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Montefiore Medical Center\/Albert Einstein College of Medicine, New York, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amie","family":"John","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Montefiore Medical Center\/Albert Einstein College of Medicine, New York, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wesley","family":"Rogers","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Weill Cornell Medicine, New York, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Westblade","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Marrero Rol\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Madison-Antenucci","sequence":"additional","affiliation":[{"name":"Parasitology Laboratory, New York State Department of Health, Albany, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phyu M.","family":"Thwe","sequence":"additional","affiliation":[{"name":"Department of Pathology, Montefiore Medical Center\/Albert Einstein College of Medicine, New York, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Orner","sequence":"additional","affiliation":[{"name":"Department of Pathology, Montefiore Medical Center\/Albert Einstein College of Medicine, New York, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerry","family":"Murphy","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Montefiore Medical Center\/Albert Einstein College of Medicine, New York, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace A.","family":"Maldarelli","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Weill Cornell Medicine, New York, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Kirkman","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Weill Cornell Medicine, New York, New York;"},{"name":"Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna P.","family":"Daily","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Montefiore Medical Center\/Albert Einstein College of Medicine, New York, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"WHO Guidelines for Malaria (WHO\/UCN\/GMP\/2023.01.)","year":"2023"},{"key":"b2","series-title":"Artemisinin Resistance and Artemisinin-Based Combination Therapy Efficacy","year":"2019"},{"key":"b3","series-title":"Malaria: Artemisinin Partial Resistance","year":"2022"},{"key":"b4","series-title":"Clin Infect Dis","first-page":"199","article-title":"High rate of treatment failures in nonimmune travelers treated with artemether\u2013lumefantrine for uncomplicated Plasmodium falciparum malaria in Sweden: Retrospective comparative analysis of effectiveness and case 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