{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T19:22:29Z","timestamp":1746386549311,"version":"3.37.0"},"reference-count":43,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","license":[{"start":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T00:00:00Z","timestamp":1738713600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,5]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Malaria in pregnancy increases maternal and perinatal morbidity and mortality. Indoor residual spraying (IRS) is a core vector control strategy used to reduce transmission in endemic areas; however, its efficacy in reducing the sequelae of malaria in pregnancy is not well described. PubMed, Embase, Cochrane, and Web of Science were searched for all studies assessing IRS exposure during pregnancy. Abstracts and full texts were reviewed independently by two researchers, with discrepancies adjudicated by a third. Of 3,319 studies that met the search criteria, 17 met the inclusion criteria. Thirteen studies reported on the effect of IRS on malaria endpoints during pregnancy, five on birth outcomes, and one on a fetal anomaly. Twelve of the 13 studies exploring maternal malaria and 3 of 3 studies reporting on placental malaria demonstrated a reduction among those exposed to IRS during pregnancy. Results were more mixed for obstetric outcomes. Two of the best-quality studies showed reductions in preterm birth, low birthweight, and fetal\/neonatal mortality; a third high-quality study did not demonstrate a reduction in perinatal mortality but did not evaluate preterm birth. One study found a significantly increased risk of preterm birth in those exposed to IRS, although the study was of lower quality. A final study demonstrated a small, although statistically significant, association between IRS and male urogenital birth defects. In malaria-endemic areas, the published literature suggests that IRS during pregnancy reduces the incidence of malaria parasitemia. However, without high-quality prospective studies directly examining IRS in pregnancy, the impact on birth outcomes is less clear.<\/jats:p>","DOI":"10.4269\/ajtmh.24-0435","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T21:23:51Z","timestamp":1730237031000},"page":"253-265","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Indoor Residual Spraying on Malaria in Pregnancy and Pregnancy Outcomes: A Systematic Review"],"prefix":"10.4269","volume":"112","author":[{"given":"Austin","family":"Oberlin","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tesia G.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Mass General Brigham Medical Center, Boston, Massachusetts;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrienne Pettiette","family":"Erlinger","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Beth Israel Deaconness Medical Center, Boston, Massachusetts;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avina","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Beth Israel Deaconness Medical Center, Boston, Massachusetts;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halimatou","family":"Diawara","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Centre, University of Science Techniques and Technologies of Bamako, Bamako, Mali;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara A.","family":"Healy","sequence":"additional","affiliation":[{"name":"Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alassane","family":"Dicko","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Centre, University of Science Techniques and Technologies of Bamako, Bamako, Mali;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick E.","family":"Duffy","sequence":"additional","affiliation":[{"name":"Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Hacker","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Beth Israel Deaconness Medical Center, Boston, Massachusetts;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blair J.","family":"Wylie","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"year":"2022","series-title":"World Malaria Report 2022","key":"b1"},{"key":"b2","series-title":"Semin Perinatol","first-page":"282","article-title":"An overview of malaria in pregnancy","volume":"43","author":"Bauserman","year":"2019"},{"key":"b3","series-title":"Parasitology","first-page":"1877","article-title":"Plasmodium in the placenta: Parasites, parity, protection, prevention and possibly preeclampsia","volume":"134","author":"Duffy","year":"2007"},{"key":"b4","series-title":"Lancet Infect Dis","first-page":"93","article-title":"Epidemiology and burden of malaria in pregnancy","volume":"7","author":"Desai","year":"2007"},{"year":"2023","series-title":"WHO Consolidated Guidelines for Malaria","key":"b5"},{"year":"2015","series-title":"Indoor Residual Spraying: An Operational Manual for IRS for Malaria Transmission, Control and Elimination","key":"b6"},{"year":"2024","key":"b7"},{"key":"b8","series-title":"Am J Trop Med Hyg","first-page":"117","article-title":"Reduction of malaria prevalence by indoor residual spraying: A meta-regression analysis","volume":"87","author":"Kim","year":"2012"},{"key":"b9","series-title":"Infect Dis Poverty","first-page":"83","article-title":"Effectiveness of indoor residual spraying on malaria control: A systematic review and meta-analysis","volume":"11","author":"Zhou","year":"2022"},{"key":"b10","series-title":"Toxicol Appl Pharmacol","first-page":"246","article-title":"Biomarkers in assessing residential insecticide exposures during pregnancy and effects on fetal growth","volume":"206","author":"Whyatt","year":"2005"},{"key":"b11","series-title":"Environ Health Perspect","first-page":"1055","article-title":"Associations of prenatal 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Nigeria","volume":"2","author":"Agomo","year":"2013"},{"key":"b16","series-title":"Trop J Pharm Res","first-page":"1103","article-title":"Assessment of knowledge, interventional practices for, and impact of malaria in pregnancy among parturient women in a Nigerian tertiary healthcare facility","volume":"14","author":"Obieche","year":"2015"},{"key":"b17","series-title":"Korean J Parasitol","first-page":"365","article-title":"Use and effects of malaria control measures in pregnancy in Lagos, Nigeria","volume":"49","author":"Efunshile","year":"2011"},{"key":"b18","series-title":"Int J Epidemiol","first-page":"1","article-title":"Plasmodiasis among pregnant women in Enugu, Nigeria: Prevalence and risk factors","volume":"15","author":"Maduakor","year":"2019"},{"key":"b19","series-title":"Sci Afr","first-page":"e01668","article-title":"A cross-sectional study of risk factors associated with malaria diseases in pregnant women attending a state hospital Iwo Osun State, Southwest Nigeria","volume":"20","author":"Oladosu","year":"2023"},{"key":"b20","series-title":"PLoS One","first-page":"e0293420","article-title":"Prevalence and determinants of malaria infection among pregnant women attending antenatal clinic in Ejisu government hospital in Ghana: A cross-sectional study","volume":"18","author":"Dwumfour","year":"2023"},{"key":"b21","series-title":"Pediatr Res","first-page":"1565","article-title":"Association between pesticide usage during pregnancy and neonatal hyperbilirubinemia requiring treatment: The Japan Environment and Children\u2019s Study","volume":"89","author":"Shibazaki","year":"2021"},{"key":"b22","series-title":"Int J Epidemiol","first-page":"1489","article-title":"Association between indoor residual spraying and pregnancy outcomes: A quasi-experimental study from Uganda","volume":"51","author":"Roh","year":"2022"},{"key":"b23","series-title":"Malar J","first-page":"437","article-title":"Reductions in malaria in pregnancy and adverse birth 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urogenital malformations in newborn boys in a malarial area","volume":"106","author":"Bornman","year":"2010"},{"key":"b28","series-title":"Malar J","first-page":"26","article-title":"Pre-elimination of malaria on the island of Pr\u00edncipe","volume":"9","author":"Lee","year":"2010"},{"key":"b29","series-title":"Malar J","first-page":"264","article-title":"Potential threat of malaria epidemics in a low transmission area, as exemplified by S\u00e3o Tom\u00e9 and Pr\u00edncipe","volume":"9","author":"Lee","year":"2010"},{"key":"b30","series-title":"BMC Pregnancy Childbirth","first-page":"60","article-title":"Utilisation of malaria preventive measures during pregnancy and birth outcomes in Ibadan, Nigeria","volume":"11","author":"Tongo","year":"2011"},{"key":"b31","series-title":"PLoS One","first-page":"e0123630","article-title":"Prevalence and predictors of asymptomatic malaria parasitemia among pregnant women in the rural surroundings of Arbaminch Town, South Ethiopia","volume":"10","author":"Nega","year":"2015"},{"key":"b32","series-title":"Trans R Soc Trop Med Hyg","first-page":"514","article-title":"Spatial patterns and determinants of malaria infection during pregnancy in Zambia","volume":"109","author":"Kamuliwo","year":"2015"},{"key":"b33","series-title":"PLoS One","first-page":"e0231477","article-title":"Prevalence of asymptomatic Plasmodium species infection and associated factors among pregnant women attending antenatal care at Fendeka town health facilities, Jawi District, North west Ethiopia: A cross-sectional study","volume":"15","author":"Tilahun","year":"2020"},{"key":"b34","series-title":"PLoS One","first-page":"e0248074","article-title":"Asymptomatic Plasmodium infection and associated factors among pregnant women in the Merti district, Oromia, Ethiopia","volume":"16","author":"Subussa","year":"2021"},{"key":"b35","series-title":"Malar J","first-page":"120","article-title":"Impact of insecticide-treated nets and indoor 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