{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T21:14:54Z","timestamp":1762982094217,"version":"3.41.0"},"reference-count":67,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,4]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Neurocysticercosis (NCC) is the most common helminthic infection of the human central nervous system (CNS), and a major cause of acquired epilepsy in most of the world. Although outcomes of NCC have been improved by advanced diagnostic tests, antiparasitic drugs, and appropriate anti-inflammatory treatment, little attention has been paid to calcified NCC. Calcification is a common outcome in NCC and carries increased risk for seizures and hippocampal atrophy\/sclerosis. The pathophysiological mechanisms leading to calcification instead of complete resolution are basically unknown. Understanding the causes and mechanisms of calcification can lead to improved therapies aimed at reducing the likelihood of residual calcification or the underlying pathological mechanisms, after the resolution of parasitic lesions in the human CNS.<\/jats:p>","DOI":"10.4269\/ajtmh.24-0446","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T16:13:43Z","timestamp":1742314423000},"page":"1187-1192","source":"Crossref","is-referenced-by-count":1,"title":["Calcified Neurocysticercosis: Understanding Dead (Not Necessarily Inactive) Parasites"],"prefix":"10.4269","volume":"112","author":[{"given":"Christina M.","family":"Coyle","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Albert Einstein College of Medicine, Bronx, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier A.","family":"Bustos","sequence":"additional","affiliation":[{"name":"Center for Global Health, Universidad Peruana Cayetano Heredia, Lima, Per\u00fa;"},{"name":"Center for Global Health, School of Health Sciences, Universidad Peruana de Ciencias Aplicadas (UPC), Lima, Per\u00fa;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar H.","family":"Del Brutto","sequence":"additional","affiliation":[{"name":"School of Medicine and Research Center, Universidad Esp\u00edritu Santo \u2013 Ecuador, Samborond\u00f3n, Ecuador;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector H.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Center for Global Health, Universidad Peruana Cayetano Heredia, Lima, Per\u00fa;"},{"name":"Cysticercosis Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Per\u00fa;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodore E.","family":"Nash","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vedantam","family":"Rajshekhar","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, Christian Medical College Ranipet Campus, Vellore, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"ScientificWorldJournal","first-page":"159821","article-title":"Neurocysticercosis: A review","volume":"2012","author":"Del Brutto","year":"2012"},{"key":"b2","series-title":"Continuum (Minneap Minn)","first-page":"943","article-title":"Parasitic infections of the nervous system","volume":"27","author":"Garcia","year":"2021"},{"key":"b3","series-title":"Res Rep Trop Med","first-page":"197","article-title":"Current diagnostic criteria for neurocysticercosis","volume":"12","author":"Guzman","year":"2021"},{"key":"b4","series-title":"Pathogens","first-page":"1212","article-title":"Human neurocysticercosis: An 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