{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T05:24:40Z","timestamp":1736400280106,"version":"3.32.0"},"reference-count":17,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,8]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Paracoccidioidomycosis is an acute to chronic systemic mycosis caused by the fungi Paracoccidioides. Hypercalcemia is a rare and not fully understood presentation of this infection. We present a case report of paracoccidioidomycosis associated with hypercalcemia and acute kidney injury (AKI) in an immunocompetent patient. An immunocompetent 30-year-old man from Brazil presented with papular erythematous-violaceous skin lesions, disseminated lymphadenopathy, pain in the left hypochondrium, fever with night sweats, and loss of 25 kilograms in 5 months. The result of a biopsy of the lesions was positive for <jats:italic>Paracoccidioides brasiliensis<\/jats:italic>. Laboratory findings were high total calcium and 1,25-dihydroxy vitamin D, with low parathyroid hormone, low albumin, and AKI. Computed tomography scans revealed splenic infarcts without bone lesions. Treatment was performed with methylprednisolone and liposomal amphotericin B. Calcium levels and kidney function normalized within 20 days of hospitalization. The patient was discharged 49 days after admission. A follow-up 6 months later revealed total clinical and serological remission.<\/jats:p>","DOI":"10.4269\/ajtmh.24-0456","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T21:23:54Z","timestamp":1730237034000},"page":"155-157","source":"Crossref","is-referenced-by-count":0,"title":["Hypercalcemia and Acute Kidney Injury Associated with Disseminated Paracoccidioidomycosis"],"prefix":"10.4269","volume":"112","author":[{"given":"Renan Gomes Mendes","family":"Diniz","sequence":"first","affiliation":[{"name":"Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betina Nogueira","family":"Da Silva","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raoni De Oliveira","family":"Domingues-Da-Silva","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina da Universidade Federal do Cear\u00e1, Fortaleza, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Arnone","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Belda J\u00fanior","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth De Francesco","family":"Daher","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina da Universidade Federal do Cear\u00e1, Fortaleza, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Andrade","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"year":"2018","series-title":"Dermatologia de Sampaio e Rivitti","author":"Rivitti","key":"b1"},{"key":"b2","series-title":"An Bras Dermatol","first-page":"700","article-title":"Paracoccidioidomycosis: Epidemiological, clinical, diagnostic and treatment up-dating","volume":"88","author":"Marques","year":"2013"},{"key":"b3","series-title":"Rev Soc Bras Med Trop","first-page":"715","article-title":"Brazilian guidelines for the clinical management of paracoccidioidomycosis","volume":"50","author":"Shikanai-Yasuda","year":"2017"},{"key":"b4","series-title":"Med Chem","first-page":"564","article-title":"Treatment of acute 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