{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:28:46Z","timestamp":1790692126253,"version":"4.1.0"},"reference-count":12,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,2]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Chagas meningoencephalitis can present in immunocompromised patients after organ transplantation. We present the first reported instance in which metagenomic next-generation sequencing (mNGS) of cerebrospinal fluid diagnosed Chagas meningoencephalitis in a patient. The diagnosis of Chagas in this case underscores the role of mNGS in identifying rare or unexpected pathogens.<\/jats:p>","DOI":"10.4269\/ajtmh.24-0553","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T20:33:38Z","timestamp":1746563618000},"page":"32-36","source":"Crossref","is-referenced-by-count":1,"title":["Chagas Meningoencephalitis Diagnosed in Heart Transplant Patient Using Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid"],"prefix":"10.4269","volume":"113","author":[{"given":"Jill","family":"Teitelbaum","sequence":"first","affiliation":[{"name":"Albert Einstein College of Medicine, Bronx, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivank","family":"Madan","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine, Bronx, New York;"},{"name":"Montefiore Medical Center, Bronx, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snehal","family":"Patel","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine, Bronx, New York;"},{"name":"Montefiore Medical Center, Bronx, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Coyle","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine, Bronx, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles Y.","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and UCSF Clinical Microbiology Laboratory, University of California San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyu M.","family":"Thwe","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine, Bronx, New York;"},{"name":"Montefiore Medical Center, Bronx, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayuko","family":"Uehara","sequence":"additional","affiliation":[{"name":"Montefiore Medical Center, Bronx, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Jermyn","sequence":"additional","affiliation":[{"name":"Montefiore Medical Center, Bronx, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vagish","family":"Hemmige","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine, Bronx, New York;"},{"name":"Montefiore Medical Center, Bronx, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Acta Trop","first-page":"22","article-title":"Chagas disease in Spain, the United States and other non-endemic countries","volume":"115","author":"Gascon","year":"2010"},{"key":"b2","series-title":"Trop Med Infect Dis","first-page":"198","article-title":"Chagas disease in people with HIV: A narrative review","volume":"6","author":"Clark","year":"2021"},{"key":"b3","series-title":"Int J Infect Dis","first-page":"587","article-title":"Reactivation of Chagas disease with central nervous system involvement in HIV-infected patients in Argentina, 1992\u20132007","volume":"12","author":"Cordova","year":"2008"},{"key":"b4","series-title":"Transplantation","first-page":"S1","article-title":"Chagas disease recommendations for solid-organ transplant recipients and donors","volume":"102","author":"Pierrotti","year":"2018"},{"key":"b5","series-title":"Transplant Rev (Orlando)","first-page":"91","article-title":"Recommendations for management of Chagas disease in organ and hematopoietic tissue transplantation programs in nonendemic areas","volume":"25","author":"Pinazo","year":"2011"},{"key":"b6","series-title":"Clin Transplant","first-page":"e13546","article-title":"Tissue and blood protozoa including toxoplasmosis, Chagas disease, leishmaniasis, Babesia, 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