{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:20:51Z","timestamp":1788355251985,"version":"build-2803163510"},"reference-count":29,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>\n                    Management of malaria-negative febrile patients is hampered by a lack of rapid diagnostic tests (RDTs) that guide treatment decisions, increasing the risks of antibiotic overuse and antimicrobial resistance. The simultaneous detection of malaria and C-reactive protein (CRP), a potentially useful host biomarker for distinguishing between bacterial and nonbacterial infections, using RDTs could help address this challenge. A prospective study was conducted at seven sites in India from April to December 2019 to evaluate the performance of the SD BIOSENSOR STANDARD\u2122 Q Malaria\/CRP Duo Test (SD BIOSENSOR, Gyeonggi-do, South Korea) against expert microscopy for malaria and against a commercial biochemistry kit for CRP, with a total of 1,799 patients with suspected malaria included in the analysis. The prevalence of malaria parasitemia according to microscopy was 13.3% (3.3%\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    [\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    ], 10.1%\n                    <jats:italic>Plasmodium vivax<\/jats:italic>\n                    [\n                    <jats:italic>P. vivax<\/jats:italic>\n                    ]). The Duo test was used to diagnose malaria,\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    , and\n                    <jats:italic>P. vivax<\/jats:italic>\n                    infections, with sensitivities of 97.9% (95% CI: 95.2%\u201399.1%), 91.4% (95% CI: 81.4%\u201396.3%), and 95.0% (95% CI: 90.7%\u201397.3%), respectively. The Duo test performed better for detecting pan malaria and\n                    <jats:italic>P. vivax<\/jats:italic>\n                    infections compared with the routine RDT (SD BIOLINE Malaria P.f\/pan antigen test; sensitivity 86.1% [95% CI: 81.1%\u201389.9%] and 79.9% [95% CI: 73.4%\u201385.1%] for malaria and\n                    <jats:italic>P. vivax<\/jats:italic>\n                    , respectively). The Duo test\u2019s sensitivity and specificity for detecting CRP at levels of 20 mg\/L or higher were estimated at 87.4% (95% CI: 84.7%\u201389.7%) and 94.0% (95% CI: 92.4%\u201395.3%), respectively. The satisfactory agreement between test results and standard reference methods suggests that the test can be used in malaria-endemic settings; however, additional studies are needed to assess its impact on malaria testing and antibiotic prescription practices.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.24-0620","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T14:09:08Z","timestamp":1784642948000},"page":"537-544","source":"Crossref","is-referenced-by-count":0,"title":["Prospective Assessment of the Performance of a Combi-Rapid Diagnostic Test to Accurately Diagnose Malaria and Detect C-Reactive Protein in Selected Settings in India"],"prefix":"10.4269","volume":"115","author":[{"given":"Bina","family":"Srivastava","sequence":"first","affiliation":[{"name":"ICMR-National Institute of Malaria Research, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anup","family":"Anvikar","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Malaria Research, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepali","family":"Anvikar","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Malaria Research, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supriya","family":"Sharma","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Malaria Research, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naseem","family":"Ahmed","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Malaria Research, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deendayal","family":"Swarnkar","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Malaria Research, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj K.","family":"Das","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Malaria Research, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khageshwar","family":"Pradhan","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Malaria Research, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuldeep","family":"Singh","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Malaria Research, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Eapen","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Malaria Research, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanal","family":"Kumar","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Malaria Research, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Keller","sequence":"additional","affiliation":[{"name":"ACOMED, Leipzig, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Weber","sequence":"additional","affiliation":[{"name":"ACOMED, Leipzig, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Mace","sequence":"additional","affiliation":[{"name":"FIND, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Ongarello","sequence":"additional","affiliation":[{"name":"FIND, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Dittrich","sequence":"additional","affiliation":[{"name":"FIND, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Incardona","sequence":"additional","affiliation":[{"name":"FIND, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","article-title":"World Malaria Report 2023.","year":"2023"},{"issue":"1","key":"b2","series-title":"Lancet Glob Health","first-page":"e46","article-title":"Causes of non-malarial fever in Laos: A prospective study","volume":"1","author":"Mayxay","year":"2013"},{"key":"b3","series-title":"Ann Clin Microbiol Antimicrob","first-page":"1","article-title":"The effect of malaria rapid diagnostic tests results on antimicrobial prescription practices of health care workers in Burkina Faso","volume":"18","author":"Kiemde","year":"2019"},{"key":"b4","series-title":"Int J Infect Dis","first-page":"276","article-title":"Evaluation of C-reactive protein and myxovirus resistance protein A to guide the rational use of 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