{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:46:22Z","timestamp":1765233982451,"version":"3.41.0"},"reference-count":17,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,4]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Dengue virus produces dengue fever, which can cause severe manifestations. Virus serotype and genotype may impact the epidemiology and severity of the disease. At the Hospital M\u00e9xico (Costa Rica), dengue diagnosis and serotyping are performed with molecular tests, but selected samples are sequenced using Illumina technology. In May 2024, we analyzed two dengue-positive samples through genomic sequencing and detected dengue serotype 2, Cosmopolitan genotype. Phylogenetic comparisons revealed that the Costa Rican genomes are closely related to those from Brazil, Peru, and Colombia. Molecular dating estimated that the sequences from Costa Rica diverged in January 2024, suggesting that this genotype may already have been circulating in the country. The emergence of this genotype could impact the severity and epidemiology of dengue in Costa Rica. Therefore, genomic and epidemiological surveillance of dengue cases locally is important to better understand the public health impact of this new genotype in the country.<\/jats:p>","DOI":"10.4269\/ajtmh.24-0633","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T16:13:38Z","timestamp":1742314418000},"page":"1300-1301","source":"Crossref","is-referenced-by-count":1,"title":["Emergence of Dengue Virus Serotype 2 Cosmopolitan Genotype in Costa Rica"],"prefix":"10.4269","volume":"112","author":[{"given":"Vanessa","family":"Villalobos-Alfaro","sequence":"first","affiliation":[{"name":"Caja Costarricense del Seguro Social, Hospital M\u00e9xico, San Jos\u00e9, Costa Rica;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Uribe-Calvo","sequence":"additional","affiliation":[{"name":"Caja Costarricense del Seguro Social, Hospital M\u00e9xico, San Jos\u00e9, Costa Rica;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenia","family":"Corrales-Aguilar","sequence":"additional","affiliation":[{"name":"Virology Section, Research Centre for Tropical Diseases and Faculty of Microbiology, University of Costa Rica, San Jos\u00e9, Costa Rica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Murillo","sequence":"additional","affiliation":[{"name":"Virology Section, Research Centre for Tropical Diseases and Faculty of Microbiology, University of Costa Rica, San Jos\u00e9, Costa Rica"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Lancet","first-page":"453","article-title":"Dengue","volume":"385","author":"Guzman","year":"2015"},{"article-title":"Bolet\u00edn Epidemiol\u00f3gico N\u00b049 de 2023.","year":"2023","author":"Alfaro-N\u00e1jera","key":"b2"},{"year":"2023","key":"b3","article-title":"Salud Confirma Circulaci\u00f3n Aut\u00f3ctona 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