{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:11:03Z","timestamp":1783123863235,"version":"3.54.6"},"reference-count":11,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,2]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Opsoclonus myoclonus ataxia syndrome (OMAS) is a rare neuroinflammatory disorder that is typically associated with paraneoplastic and postinfectious processes. Opsoclonus myoclonus ataxia syndrome has not been previously reported in association with tuberculous meningitis (TBM). This report presents a unique case in which TBM manifested as OMAS, highlighting the complex interplay between tuberculosis and autoimmune neurological conditions. A 1.5-year-old previously healthy girl, presented with acute-onset jerky movements, opsoclonus, irritability, and reduced sleep over 4 weeks. A neurological examination revealed opsoclonus, irritability, generalized tremulousness, and fragmentary myoclonus. Neuroimaging was suggestive of TBM. A cerebrospinal fluid (CSF) analysis indicated lymphocytic pleocytosis with positive CSF cartridge-based nucleic acid amplification test results for tuberculosis. The patient was treated with methylprednisolone pulse therapy, intravenous immunoglobulins, and anti-tuberculous therapy (ATT). Significant symptom improvement was observed within 2 weeks. This case underscores a rare association between OMAS and TBM, demonstrating that tuberculosis can trigger OMAS through autoimmune mechanisms. A timely diagnosis and treatment with ATT and immunotherapy can lead to substantial recovery.<\/jats:p>","DOI":"10.4269\/ajtmh.24-0664","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T14:51:07Z","timestamp":1736261467000},"page":"856-858","source":"Crossref","is-referenced-by-count":1,"title":["Opsoclonus Myoclonus Ataxia Syndrome: An Atypical Presentation of Tuberculous Meningitis"],"prefix":"10.4269","volume":"112","author":[{"given":"Diksha","family":"Gupta","sequence":"first","affiliation":[{"name":"Pediatric Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, Rishikesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achanya","family":"Palayullakandi","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, Rishikesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suthiraj","family":"Sopanam","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, Rishikesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prateek Kumar","family":"Panda","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, Rishikesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indar Kumar","family":"Sharawat","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, Rishikesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"J Neurol","first-page":"1541","article-title":"Update on opsoclonus-myoclonus syndrome in adults","volume":"266","author":"Oh","year":"2019"},{"key":"b2","series-title":"Children","first-page":"965","article-title":"Opsoclonus-myoclonus syndrome in children and adolescents: A therapeutic challenge","volume":"8","author":"Auconi","year":"2021"},{"key":"b3","series-title":"Dermatol Ther","first-page":"320","article-title":"Erythema nodosum and erythema induratum (nodular vasculitis): Diagnosis and management","volume":"23","author":"Gilchrist","year":"2010"},{"key":"b4","series-title":"Lancet","first-page":"617","article-title":"Poncet\u2019s disease: Unusual presentation of a common disease","volume":"387","author":"Arora","year":"2016"},{"key":"b5","series-title":"Oral Dis","first-page":"46","article-title":"TB-HIV co-infection: A catastrophic comradeship","volume":"22 (Suppl 1)","author":"Narendran","year":"2016"},{"key":"b6","series-title":"World J Pediatr","first-page":"19","article-title":"Immunological pathogenesis and treatment of systemic lupus erythematosus","volume":"16","author":"Pan","year":"2020"},{"key":"b7","series-title":"Annu Rev Immunol","first-page":"485","article-title":"IL-17 and Th17 cells","volume":"27","author":"Korn","year":"2009"},{"key":"b8","series-title":"BMC Infect Dis","first-page":"788","article-title":"The diagnostic utility of the \u201cThwaites\u2019 system\u201d and \u201clancet consensus scoring system\u201d in tuberculous vs. non-tuberculous subacute and chronic meningitis: Multicenter analysis of 395 adult patients","volume":"20","author":"Sulaiman","year":"2020"},{"key":"b9","series-title":"Nat Immunol","first-page":"132","article-title":"Infectious immunity in the central nervous system and brain function","volume":"18","author":"Klein","year":"2017"},{"key":"b10","series-title":"Ther Adv Neurol Disord","first-page":"1756286420932797","article-title":"Pathophysiology of paraneoplastic and autoimmune encephalitis: Genes, infections, and checkpoint inhibitors","volume":"13","author":"Vogrig","year":"2020"},{"key":"b11","series-title":"Crit Care","first-page":"236","article-title":"Infectious disease-associated encephalopathies","volume":"25","author":"Barbosa-Silva","year":"2021"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/112\/4\/article-p856.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/112\/4\/article-p856.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/112\/4\/article-p856.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T13:37:48Z","timestamp":1743601068000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/112\/4\/article-p856.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,2]]},"references-count":11,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.24-0664","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,2]]}}}