{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:00:52Z","timestamp":1788217252835,"version":"build-2803163510"},"reference-count":20,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,7]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Reports from endemic regions in Asia indicate that severe fever with thrombocytopenia syndrome virus (SFTSV), a canonically tick-borne virus, can be directly transmitted from infected humans and animals to na\u00efve hosts. To understand this process, using a feline infection model, we observed that both intramuscular inoculation and oral inoculation resulted in adult cats developing viremia, with cats inoculated intramuscularly shedding virus orally. We also observed a potential organ tropism associated with the route of inoculation. Using an immunodeficient murine model, we further demonstrated that noncanonical routes of inoculation can result in lethal infections. However, we could not replicate the organ tropism seen in cats, possibly because of the immunodeficient nature of the mice. Like cats, mice shed SFSTV orally. These results indicate that SFTSV can exist in a vector-free cycle, highlighting a need for increased surveillance and precautions when handling potentially infected animals.<\/jats:p>","DOI":"10.4269\/ajtmh.24-0731","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T21:41:56Z","timestamp":1740519716000},"page":"1036-1039","source":"Crossref","is-referenced-by-count":2,"title":["Exploring Routes of Infection of Severe Fever with Thrombocytopenia Syndrome Virus Using Experimentally Infected Animals"],"prefix":"10.4269","volume":"112","author":[{"given":"Jeffrey M.","family":"Marano","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M.","family":"Bosco-Lauth","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Exp Mol Med","first-page":"713","article-title":"Severe fever with thrombocytopenia syndrome virus: Emerging novel phlebovirus and their control strategy","volume":"53","author":"Casel","year":"2021"},{"key":"b2","series-title":"Exp Appl Acarol","first-page":"305","article-title":"Severe fever with thrombocytopenia syndrome virus from ticks: A molecular epidemiological study of a patient in the Republic of Korea","volume":"89","author":"Kim","year":"2023"},{"key":"b3","series-title":"Int J Environ Res Public Health","first-page":"3092","article-title":"Epidemiological characteristics of severe fever with thrombocytopenia syndrome from 2010 to 2019 in mainland China","volume":"18","author":"Huang","year":"2021"},{"key":"b4","series-title":"Ticks Tick Borne Dis","first-page":"102115","article-title":"Seroprevalence of severe fever with thrombocytopenia syndrome virus 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veterinary personnel","volume":"26","author":"Yamanaka","year":"2020"},{"key":"b9","series-title":"Int J Infect Dis","first-page":"80","article-title":"Human-to-human transmission of severe fever with thrombocytopenia syndrome virus through potential ocular exposure to infectious blood","volume":"123","author":"Wu","year":"2022"},{"key":"b10","series-title":"J Infect Dis","first-page":"736","article-title":"Human-to-human transmission of severe fever with thrombocytopenia syndrome bunyavirus through contact with infectious blood","volume":"207","author":"Tang","year":"2013"},{"key":"b11","series-title":"Int J Infect Dis","first-page":"95","article-title":"Nosocomial outbreak of severe fever with thrombocytopenia syndrome among healthcare workers in a single hospital in Daegu, Korea","volume":"119","author":"Bae","year":"2022"},{"key":"b12","series-title":"Top Companion Anim Med","first-page":"100756","article-title":"Clinical and pathological findings in fatal cases of severe fever 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