{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T04:45:50Z","timestamp":1782017150354,"version":"3.54.5"},"reference-count":21,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,4]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Drug-resistant invasive non-typhoidal <jats:italic>Salmonella<\/jats:italic> poses a significant challenge to the management of acute febrile illnesses in Uganda. However, the characteristics of invasive non-typhoidal <jats:italic>Salmonella<\/jats:italic> strains are not yet well understood. This study aimed to determine the serotypes and antimicrobial resistance patterns of invasive non-typhoidal <jats:italic>Salmonella<\/jats:italic> isolates from a local health center in Uganda. Invasive non-typhoidal <jats:italic>Salmonella<\/jats:italic> isolates archived over 5 years from febrile patients at a local health center were characterized for serotypes and antimicrobial susceptibility patterns using conventional methods. Among the 80 archived isolates, 18 serotypes of invasive non-typhoidal <jats:italic>Salmonella<\/jats:italic> were identified, with <jats:italic>Salmonella<\/jats:italic> Typhimurium (42.5%), <jats:italic>Salmonella<\/jats:italic> Enteritidis (20%), and <jats:italic>Salmonella<\/jats:italic> Haifa (8.8%) being the most prevalent. A total of 81.3% (65\/80) of the isolates exhibited resistance to at least one antibiotic, with the highest resistance rates observed for streptomycin (72.5%), trimethoprim-sulfamethoxazole (66.2%), and ampicillin (56.2%). The most common antimicrobial resistance profile, found in 23.1% (15\/65) of resistant isolates, was Amp-C-S10-S300-SXT. Notably, 81.5% of the drug-resistant isolates were multi-drug resistant. Invasive non-typhoidal <jats:italic>Salmonella<\/jats:italic> in this setting have a high rate of antimicrobial resistance to commonly used antibiotics. Improved treatment guidelines could be adapted for better clinical outcomes.<\/jats:p>","DOI":"10.4269\/ajtmh.24-0772","type":"journal-article","created":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T14:10:50Z","timestamp":1743516650000},"page":"1256-1259","source":"Crossref","is-referenced-by-count":1,"title":["Serotypes and Antimicrobial Resistance Patterns of Invasive Non-Typhoidal Salmonella in Uganda"],"prefix":"10.4269","volume":"112","author":[{"given":"John Bosco","family":"Kalule","sequence":"first","affiliation":[{"name":"Department of Biotechnical and Diagnostic Sciences (BDS), College of Veterinary Medicine, Animal Resources and Biosecurity (CoVAB), Makerere University, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Nakintu Zalwango","sequence":"additional","affiliation":[{"name":"Department of Biotechnical and Diagnostic Sciences (BDS), College of Veterinary Medicine, Animal Resources and Biosecurity (CoVAB), Makerere University, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Kyazike","sequence":"additional","affiliation":[{"name":"Department of Biotechnical and Diagnostic Sciences (BDS), College of Veterinary Medicine, Animal Resources and Biosecurity (CoVAB), Makerere University, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Majalija","sequence":"additional","affiliation":[{"name":"National Livestock Resources Research Institute (NALIRRI), National Agricultural Research Organization (NARO), Namulonge, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Lancet Infect Dis","first-page":"P1312","article-title":"The global burden of non-typhoidal Salmonella invasive disease: A systematic analysis for the Global Burden of Disease Study 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Serovars","first-page":"1","author":"Grimont","year":"2007"},{"key":"b12","article-title":"RStudio.","year":"2024"},{"key":"b13","series-title":"Emerg Infect Dis","first-page":"941","article-title":"Global burden of invasive nontyphoidal Salmonella disease, 2010(1)","volume":"21","author":"Ao","year":"2015"},{"key":"b14","series-title":"Lancet Infect Dis","first-page":"692","article-title":"Complications and mortality of non-typhoidal Salmonella invasive disease: A global systematic review and meta-analysis","volume":"22","author":"Marchello","year":"2022"},{"key":"b15","series-title":"Clin Infect Dis","first-page":"S317","article-title":"Epidemiology and genomics of invasive nontyphoidal Salmonella infections in Kenya","volume":"61 Suppl 4","author":"Kariuki","year":"2015"},{"key":"b16","series-title":"BMC Med","first-page":"212","article-title":"Invasive non-typhoidal Salmonella infections in sub-Saharan Africa: A systematic review on antimicrobial resistance and 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