{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:30:40Z","timestamp":1791570640588,"version":"4.3.4"},"reference-count":37,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,2]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Epstein\u2013Barr virus (EBV) infects over 90% of the global population and establishes lifelong persistence. Although early childhood infections are often asymptomatic, EBV infection during adolescence can cause infectious mononucleosis, several malignancies, and posttransplant lymphoproliferative disorders. The timing of EBV infection and seroprevalence varies globally based on geographic and socioeconomic factors; however, comprehensive and updated data for Thailand are limited. This study investigated EBV seroprevalence across age groups in four provinces representing Thailand\u2019s regions, comparing findings with previous data and exploring correlations with economic and health care indicators. Serum samples (<jats:italic>N<\/jats:italic> = 1,274) were collected between May and August 2024 from participants ages 6 months old to 80 years old in Ayutthaya, Uttaradit, Buri Ram, and Trang provinces. EBV capsid antigen IgG levels were measured using ELISA. Age-specific seroprevalence increased from 35.9% in infants (6 months old to 2 years old) to nearly 100% in adolescents and adults, with varying antibody levels between age groups. Comparisons with historical data illustrated consistent trends of early EBV acquisition in childhood, but the infection increased slightly slower than in the past. Compared with other countries, EBV seroprevalence in Thailand and other developing countries occurred earlier than in developed countries. Linear regression analysis revealed a significant correlation between age at 50% and 75% EBV seropositive and a national economic indicator (gross domestic product per capita). These findings found little changes in EBV epidemiology over time and provided updated information and analysis to support public health strategies.<\/jats:p>","DOI":"10.4269\/ajtmh.24-0857","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T17:39:07Z","timestamp":1745948347000},"page":"86-93","source":"Crossref","is-referenced-by-count":4,"title":["Epstein\u2013Barr Virus Seroprevalence in Thailand: A Temporal and Global Perspective with Health Care and Economic Correlations"],"prefix":"10.4269","volume":"113","author":[{"given":"Lita","family":"Tantipraphat","sequence":"first","affiliation":[{"name":"Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand;"},{"name":"Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narakit","family":"Sudhinaraset","sequence":"additional","affiliation":[{"name":"Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand;"},{"name":"Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanunrat","family":"Thongmee","sequence":"additional","affiliation":[{"name":"Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sitthichai","family":"Kanokudom","sequence":"additional","affiliation":[{"name":"Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pornjarim","family":"Nilyanimit","sequence":"additional","affiliation":[{"name":"Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natthinee","family":"Sudhinaraset","sequence":"additional","affiliation":[{"name":"Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Poovorawan","sequence":"additional","affiliation":[{"name":"Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand;"},{"name":"The Royal Society of Thailand, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Sherris & Ryan\u2019s Medical Microbiology","author":"Admad","year":"2022"},{"key":"b2","series-title":"Harrison\u2019s Principles of Internal Medicine","author":"Cohen","year":"2022"},{"key":"b3","series-title":"Current Medical Diagnosis & Treatment 2024","author":"Clark","year":"2024"},{"key":"b4","series-title":"J Glob Health","first-page":"010404","article-title":"Predictors of Epstein\u2013Barr virus serostatus and implications for vaccine policy: A systematic review of the literature","volume":"10","author":"Winter","year":"2020"},{"key":"b5","series-title":"Asian Pac J Cancer Prev","first-page":"7583","article-title":"Seroprevalence of anti-EBV IgG among various age groups from Khon Kaen Province, Thailand","volume":"16","author":"Suntornlohanakul","year":"2015"},{"key":"b6","series-title":"J Med Assoc Thai","first-page":"850","article-title":"Seroprevalence 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