{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:55:54Z","timestamp":1780545354770,"version":"3.54.1"},"reference-count":110,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,7]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>\n                    Acute undifferentiated febrile illness (AUFI) is associated with several etiological agents, including vector-borne pathogens. In tropical areas endemic for multiple pathogens, it is difficult to efficiently determine the etiology of AUFI. The goal for this study was to diagnose several arboviruses and other pathogens in patients with AUFI in Yucatan, Mexico, during the final phase of the coronavirus disease 2019 pandemic. A total of 215 patients with AUFI were included, with 170 from the urban area of Merida City and 45 from the rural area of the Molas community. Between December 2022 and December 2023, subjects were enrolled at health facilities, one in the rural area and two in the urban area. Overall, 36.7% (79\/215) of AUFI patients were confirmed to have dengue virus (DENV). A significant difference (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05) was found in the prevalence of dengue in the urban area (84.8%) compared with that in the rural area (15.2%). When diagnosed patients were grouped by age, most cases occurred in young adults (17\u201329 years old). Acute infections caused by\n                    <jats:italic>Leptospira interrogans<\/jats:italic>\n                    (\n                    <jats:italic>L. interrogans<\/jats:italic>\n                    ) serovars\n                    <jats:italic>Bratislava<\/jats:italic>\n                    and\n                    <jats:italic>Australis<\/jats:italic>\n                    ,\n                    <jats:italic>Rickettsia<\/jats:italic>\n                    spp., and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were also identified in patients with AUFI. In Merida City, five cases of multiple infections were found with dengue, SARS-CoV-2, and\n                    <jats:italic>L. interrogans<\/jats:italic>\n                    serovars\n                    <jats:italic>Bratislava<\/jats:italic>\n                    and\n                    <jats:italic>Australis.<\/jats:italic>\n                    In conclusion, DENV was confirmed as the main causative agent of AUFI in the present study; however, the simultaneous circulation of other relevant endemic causal agents that cause febrile infections in the area is a key point to consider when making differential diagnoses.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.25-0046","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T17:04:02Z","timestamp":1762448642000},"page":"161-169","source":"Crossref","is-referenced-by-count":1,"title":["Surveillance for Dengue Virus and Other Pathogens in Patients with Acute Undifferentiated Febrile Illnesses in Yucatan, Mexico, During the Final Phase of the Coronavirus Disease 2019 Pandemic"],"prefix":"10.4269","volume":"114","author":[{"given":"Lourdes G.","family":"Talavera-Aguilar","sequence":"first","affiliation":[{"name":"Laboratorio de Arbovirolog\u00eda, Centro de Investigaciones Regionales \u2018\u2018Dr. Hideyo Noguchi,\u2019\u2019 Universidad Aut\u00f3noma de Yucat\u00e1n, Merida, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos M.","family":"Baak-Baak","sequence":"additional","affiliation":[{"name":"Laboratorio de Arbovirolog\u00eda, Centro de Investigaciones Regionales \u2018\u2018Dr. Hideyo Noguchi,\u2019\u2019 Universidad Aut\u00f3noma de Yucat\u00e1n, Merida, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa C.","family":"Cetina-Trejo","sequence":"additional","affiliation":[{"name":"Laboratorio de Arbovirolog\u00eda, Centro de Investigaciones Regionales \u2018\u2018Dr. Hideyo Noguchi,\u2019\u2019 Universidad Aut\u00f3noma de Yucat\u00e1n, Merida, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro E.","family":"Salazar-Vazquez","sequence":"additional","affiliation":[{"name":"Laboratorio de Arbovirolog\u00eda, Centro de Investigaciones Regionales \u2018\u2018Dr. Hideyo Noguchi,\u2019\u2019 Universidad Aut\u00f3noma de Yucat\u00e1n, Merida, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio C.","family":"Tzuc-Dzul","sequence":"additional","affiliation":[{"name":"Laboratorio de Arbovirolog\u00eda, Centro de Investigaciones Regionales \u2018\u2018Dr. Hideyo Noguchi,\u2019\u2019 Universidad Aut\u00f3noma de Yucat\u00e1n, Merida, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilbert A.","family":"Chi-Chim","sequence":"additional","affiliation":[{"name":"Laboratorio de Arbovirolog\u00eda, Centro de Investigaciones Regionales \u2018\u2018Dr. Hideyo Noguchi,\u2019\u2019 Universidad Aut\u00f3noma de Yucat\u00e1n, Merida, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Jimenez-Coello","sequence":"additional","affiliation":[{"name":"Laboratorio de Microbiolog\u00eda, Centro de Investigaciones Regionales \u2018\u2018Dr. Hideyo Noguchi,\u2019\u2019 Universidad Aut\u00f3noma de Yucat\u00e1n, Merida, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Ortega-Pacheco","sequence":"additional","affiliation":[{"name":"Departamento de Salud Animal y Medicina Preventiva, Universidad Aut\u00f3noma de Yucat\u00e1n, Merida, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Melby","sequence":"additional","affiliation":[{"name":"Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas;"},{"name":"Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia V.","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas;"},{"name":"Department of Pathology, University of Texas Medical Branch, Galveston, Texas;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Walker","sequence":"additional","affiliation":[{"name":"Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas;"},{"name":"Department of Pathology, University of Texas Medical Branch, Galveston, Texas;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel Mauricio","family":"Cabada","sequence":"additional","affiliation":[{"name":"Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas;"},{"name":"Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas;"},{"name":"Sede Cusco-Instituto de Medicina Tropical \u201cAlexander von Humboldt,\u201d Universidad Peruana Cayetano Heredia, Lima, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian E.","family":"Garcia-Rejon","sequence":"additional","affiliation":[{"name":"Laboratorio de Arbovirolog\u00eda, Centro de Investigaciones Regionales \u2018\u2018Dr. Hideyo Noguchi,\u2019\u2019 Universidad Aut\u00f3noma de Yucat\u00e1n, Merida, Mexico;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Am J Trop Med Hyg","first-page":"1515","article-title":"Cluster analysis of dengue morbidity and mortality in Mexico from 2007 to 2020: Implications for the probable case definition","volume":"106","author":"Baak-Baak","year":"2022"},{"key":"b2","series-title":"Rev Inst Med Trop Sao Paulo","first-page":"449","article-title":"Epidemic dengue 4 in the Yucat\u00e1n, M\u00e9xico, 1984","volume":"35","author":"Loro\u00f1o Pino","year":"1993"},{"key":"b3","series-title":"Am J Trop Med Hyg","first-page":"896","article-title":"Evidence of coinfections between SARS-CoV-2 and select arboviruses in Guerrero, Mexico, 2020\u20132021","volume":"106","author":"Nunez-Avellaneda","year":"2022"},{"key":"b4","series-title":"Gac Med Mex","first-page":"359","article-title":"Indirect impact of COVID-19 on the incidence rates of vector-borne diseases in Mexico","volume":"158","author":"Cigarroa-Toledo","year":"2022"},{"key":"b5","series-title":"Ann NY Acad Sci","first-page":"327","article-title":"Detection of a typhus group Rickettsia in Amblyomma ticks in the state of Nuevo Leon, Mexico","volume":"1063","author":"Medina-Sanchez","year":"2005"},{"key":"b6","series-title":"Am J Trop Med Hyg","first-page":"157","article-title":"Unrecognized spotted fever group rickettsiosis masquerading as dengue fever in Mexico","volume":"55","author":"Zavala-Velazquez","year":"1996"},{"key":"b7","series-title":"Infez Med","first-page":"517","article-title":"Etiological characterization of acute undifferentiated febrile illness in Apartad\u00f3 and Villeta municipalities, Colombia, during COVID-19 pandemic","volume":"31","author":"Silva-Ramos","year":"2023"},{"key":"b8","series-title":"Am J Trop Med Hyg","first-page":"875","article-title":"Undifferentiated febrile illness in Kathmandu, Nepal","volume":"92","author":"Thompson","year":"2015"},{"key":"b9","series-title":"BMJ Open","first-page":"e083560","article-title":"Establishment of a multisite umbrella cohort study protocol to describe the epidemiology and aetiologies of acute undifferentiated febrile illness in Latin America","volume":"14","author":"Cabada","year":"2024"},{"key":"b10","series-title":"Rev Med Inst Mex Seguro Soc","first-page":"347","article-title":"Arbovirus causales de fiebre hemorr\u00e1gica en pacientes del Instituto Mexicano del Seguro Social","volume":"44","author":"Navarrete-Espinosa","year":"2006"},{"key":"b11","article-title":"Panorama Sociodemogr\u00e1fico de Yucat\u00e1n.","year":"2020"},{"key":"b12","series-title":"J Clin Microbiol","first-page":"2172","article-title":"Development of an internally controlled real-time reverse transcriptase PCR assay for pan-dengue virus detection and comparison of four molecular dengue virus detection assays","volume":"51","author":"Waggoner","year":"2013"},{"key":"b13","series-title":"J Med Virol","first-page":"1681","article-title":"Development of multiplex real-time reverse-transcriptase polymerase chain reaction assay for simultaneous detection of Zika, dengue, yellow fever, and chikungunya viruses in a single tube","volume":"90","author":"Wu","year":"2018"},{"key":"b14","series-title":"Diagn Microbiol Infect Dis","first-page":"114894","article-title":"Real-time RT-PCR for the detection and quantitation of oropuche virus","volume":"96","author":"Rojas","year":"2020"},{"key":"b15","series-title":"Am J Trop Med Hyg","first-page":"422","article-title":"Isolation of eastern equine encephalitis virus and West Nile virus from crows during increased arbovirus surveillance in Connecticut, 2000","volume":"66","author":"Beckwith","year":"2002"},{"key":"b16","series-title":"J Virol Methods","first-page":"93","article-title":"Detection of Zika virus by SYBR green one-step real-time RT-PCR","volume":"236","author":"Xu","year":"2016"},{"key":"b17","series-title":"Emerg Infect Dis","first-page":"237","article-title":"Spotted fever group and typhus group rickettsioses in humans, South Korea","volume":"11","author":"Choi","year":"2005"},{"key":"b18","series-title":"Microorganisms","first-page":"674","article-title":"The presence of a virulent clone of Leptospira interrogans serovar canicola in confirmed cases of asymptomatic dog carriers in Mexico","volume":"12","author":"Carmona Gasca","year":"2024"},{"key":"b19","series-title":"Pathogens","first-page":"3","article-title":"Clinical manifestations in a fatal case of probable Rickettsia and Leptospira coinfection in Yucatan, Mexico","volume":"10","author":"Dzul-Rosado","year":"2021"},{"key":"b20","series-title":"PLoS Negl Trop Dis","first-page":"e0007205","article-title":"A simple score to predict severe leptospirosis","volume":"13","author":"Smith","year":"2019"},{"key":"b21","series-title":"Diagnostics","first-page":"1455","article-title":"Diagnosis of human leptospirosis: Comparison of microscopic agglutination test with recombinant LigA\/B antigen-based in-house IgM dot ELISA dipstick test and latex agglutination test using Bayesian latent class model and MAT as gold standard","volume":"12","author":"Behera","year":"2022"},{"key":"b22","article-title":"RStudio: Integrated Development Environment for R","year":"2025"},{"key":"b23","series-title":"Am J Trop Med Hyg","first-page":"940","article-title":"Dengue virus-infected Aedes aegypti in the home environment","volume":"79","author":"Garcia-Rejon","year":"2008"},{"key":"b24","series-title":"Emerg Infect Dis","first-page":"1804","article-title":"Chikungunya virus in febrile humans and Aedes aegypti mosquitoes, Yucatan, Mexico","volume":"22","author":"Cigarroa-Toledo","year":"2016"},{"key":"b25","series-title":"Front Vet Sci","first-page":"1057686","article-title":"Molecular survey of Zika virus in the animal-human interface in traditional farming","volume":"9","author":"Lopez-Apodaca","year":"2022"},{"key":"b26","series-title":"Parasite Epidemiol Control","first-page":"e00088","article-title":"Preliminary epidemiological findings of Leishmania infection in the municipality of Tinum, Yucatan State, Mexico","volume":"4","author":"Lor\u00eda-Cervera","year":"2019"},{"key":"b27","series-title":"Zoonoses Public Health","first-page":"382","article-title":"Molecular confirmation of Rickettsia parkeri in humans from Southern Mexico","volume":"69","author":"Torres-Castro","year":"2022"},{"key":"b28","series-title":"Emerg Infect Dis","first-page":"1665","article-title":"Human rickettsialpox, southeastern Mexico","volume":"15","author":"Zavala-Castro","year":"2009"},{"key":"b29","series-title":"Emerg Infect Dis","first-page":"672","article-title":"Fatal human infection with Rickettsia rickettsii, Yucat\u00e1n, Mexico","volume":"12","author":"Zavala-Castro","year":"2006"},{"key":"b30","series-title":"BMC Public Health","first-page":"824","article-title":"Rural-urban comparisons of dengue seroprevalence in Malaysia","volume":"16","author":"Chew","year":"2016"},{"key":"b31","series-title":"J Vector Borne Dis","first-page":"176","article-title":"Prevalence of dengue vectors, larval breeding habitats, Stegomyia indices and their correlation with dengue cases in urban and rural areas of Punjab, India","volume":"57","author":"Devi","year":"2020"},{"key":"b32","series-title":"Viruses","first-page":"769","article-title":"Retrospective analysis of severe dengue by dengue virus serotypes in a population with social security, Mexico 2023","volume":"16","author":"Hern\u00e1ndez Bautista","year":"2024"},{"key":"b33","series-title":"Indian J Med Microbiol","first-page":"82","article-title":"A study on gender-related differences in laboratory characteristics of dengue fever","volume":"34","author":"Chakravarti","year":"2016"},{"key":"b34","series-title":"J Vector Borne Dis","first-page":"366","article-title":"Determination of DNA of women and men in the blood meal of Aedes aegypti based on the amelogenin and SRY genes","volume":"57","author":"Garcia-Rejon","year":"2020"},{"key":"b35","series-title":"Drugs Ther Perspect","first-page":"565","article-title":"Self-medication during Covid-19 pandemic: Challenges and opportunities","volume":"36","author":"Malik","year":"2020"},{"key":"b36","article-title":"Guidelines for the Regulatory Assessment of Medicinal Products for Use in Self-Medication.","year":"2000"},{"key":"b37","series-title":"Curr Drug Saf","first-page":"315","article-title":"Risks of self-medication practices","volume":"5","author":"Ruiz","year":"2010"},{"key":"b38","series-title":"Front Public Heal","first-page":"1176730","article-title":"Prevalence and impacts of self-medication in a disadvantaged setting: The importance of multi-dimensional health interventions","volume":"11","author":"Nguyen","year":"2023"},{"key":"b39","series-title":"Pharmacy","first-page":"183","article-title":"Patterns of drug utilization and self-medication practices: A cross sectional study","volume":"11","author":"Al-Omrani","year":"2023"},{"key":"b40","series-title":"Front Public Heal","first-page":"1184882","article-title":"A systematic review of self-medication practice during the COVID-19 pandemic: Implications for pharmacy practice in supporting public health measures","volume":"11","author":"Zheng","year":"2023"},{"key":"b41","series-title":"Travel Med Infect Dis","first-page":"102132","article-title":"Characteristics of patients coinfected with Severe Acute Respiratory Syndrome Coronavirus 2 and dengue virus, Lambayeque, Peru, May \u2013 August 2020: A retrospective analysis","volume":"43","author":"Mej\u00eda-Parra","year":"2021"},{"key":"b42","series-title":"Rev Inst Med Trop Sao Paulo","first-page":"e23","article-title":"Pathology and pathogenesis of human leptospirosis: A commented review","volume":"60","author":"De Brito","year":"2018"},{"key":"b43","series-title":"Rev Panam Salud Publica","first-page":"e126","article-title":"Prevalence of human leptospirosis in the Americas: A systematic review and meta-analysis","volume":"47","author":"Browne","year":"2023"},{"key":"b44","series-title":"Rev Salud Publica (Bogota)","first-page":"1","article-title":"Epidemiologic behavior of leptospirosis in M\u00e9xico during the period 2013\u20132019","volume":"22","author":"Yescas-Ben\u00edtez","year":"2020"},{"key":"b45","series-title":"J Zoonotic Dis","first-page":"1","article-title":"Leptospira spp. in cats from tropical Mexico","volume":"4","author":"Ortega-Pacheco","year":"2020"},{"key":"b46","series-title":"Vet Med Sci","first-page":"40","article-title":"Serological survey of Leptospira interrogans, Toxoplasma gondii and Trypanosoma cruzi in free roaming domestic dogs and cats from a marginated rural area of Yucatan Mexico","volume":"3","author":"Ortega-Pacheco","year":"2017"},{"key":"b47","series-title":"BMC Infect Dis","first-page":"186","article-title":"Leptospirosis in an asplenic patient -case report","volume":"20","author":"Garc\u00eda-M\u00e9ndez","year":"2020"},{"key":"b48","series-title":"Anthrozoos","first-page":"261","article-title":"A survey of dog populations in Urban and rural areas of Yucatan, Mexico","volume":"20","author":"Ortega-Pacheco","year":"2007"},{"key":"b49","series-title":"Rev Peru Med Exp Salud Publica","first-page":"434","article-title":"Diagnostic performance of the rapid test for the detection of NS1 antigen and IgM and IgG anti-antibodies against dengue virus","volume":"39","author":"Valdivia-Conroy","year":"2022"},{"key":"b50","series-title":"J Microbiol Immunol Infect","first-page":"358","article-title":"Laboratory diagnostics of dengue fever: An emphasis on the role of commercial dengue virus nonstructural protein 1 antigen rapid test","volume":"46","author":"Huang","year":"2013"},{"key":"b51","series-title":"PLoS Negl Trop Dis","first-page":"e3171","article-title":"Evaluation of commercially available diagnostic tests for the detection of dengue virus NS1 antigen and anti-dengue virus IgM antibody","volume":"8","author":"Hunsperger","year":"2014"},{"key":"b52","series-title":"Cochrane Database Syst Rev","first-page":"CD013705","article-title":"Rapid, point-of-care antigen tests for diagnosis of SARS-CoV-2 infection","volume":"7","author":"Dinnes","year":"2022"},{"key":"b53","series-title":"Organ Mund la Salud","first-page":"1","article-title":"Leptospirosis Humana. Gu\u00eda para el diagnostico","volume":"9","year":"2008"},{"key":"b54","series-title":"J Trop Med","first-page":"5567081","article-title":"Clinical features and severity of leptospirosis cases reported in the Hawke\u2019s Bay Region of New Zealand","volume":"2021","author":"Sellors","year":"2021"},{"key":"b55","article-title":"Panorama Epidemiol\u00f3gico de Dengue, Semana Epidemiol\u00f3gica 52 de 2023.","author":"Ceballos","year":"2023"},{"key":"b1","series-title":"Am J Trop Med Hyg","first-page":"1515","article-title":"Cluster analysis of dengue morbidity and mortality in Mexico from 2007 to 2020: Implications for the probable case definition","volume":"106","author":"Baak-Baak","year":"2022"},{"key":"b2","series-title":"Rev Inst Med Trop Sao Paulo","first-page":"449","article-title":"Epidemic dengue 4 in the Yucat\u00e1n, M\u00e9xico, 1984","volume":"35","author":"Loro\u00f1o Pino","year":"1993"},{"key":"b3","series-title":"Am J Trop Med Hyg","first-page":"896","article-title":"Evidence of coinfections between SARS-CoV-2 and select arboviruses in Guerrero, Mexico, 2020\u20132021","volume":"106","author":"Nunez-Avellaneda","year":"2022"},{"key":"b4","series-title":"Gac Med Mex","first-page":"359","article-title":"Indirect impact of COVID-19 on the incidence rates of vector-borne diseases in Mexico","volume":"158","author":"Cigarroa-Toledo","year":"2022"},{"key":"b5","series-title":"Ann NY Acad Sci","first-page":"327","article-title":"Detection of a typhus group Rickettsia in Amblyomma ticks in the state of Nuevo Leon, Mexico","volume":"1063","author":"Medina-Sanchez","year":"2005"},{"key":"b6","series-title":"Am J Trop Med Hyg","first-page":"157","article-title":"Unrecognized spotted fever group rickettsiosis masquerading as dengue fever in Mexico","volume":"55","author":"Zavala-Velazquez","year":"1996"},{"key":"b7","series-title":"Infez Med","first-page":"517","article-title":"Etiological characterization of acute undifferentiated febrile illness in Apartad\u00f3 and Villeta municipalities, Colombia, during COVID-19 pandemic","volume":"31","author":"Silva-Ramos","year":"2023"},{"key":"b8","series-title":"Am J Trop Med Hyg","first-page":"875","article-title":"Undifferentiated febrile illness in Kathmandu, Nepal","volume":"92","author":"Thompson","year":"2015"},{"key":"b9","series-title":"BMJ Open","first-page":"e083560","article-title":"Establishment of a multisite umbrella cohort study protocol to describe the epidemiology and aetiologies of acute undifferentiated febrile illness in Latin America","volume":"14","author":"Cabada","year":"2024"},{"key":"b10","series-title":"Rev Med Inst Mex Seguro Soc","first-page":"347","article-title":"Arbovirus causales de fiebre hemorr\u00e1gica en pacientes del Instituto Mexicano del Seguro Social","volume":"44","author":"Navarrete-Espinosa","year":"2006"},{"key":"b11","article-title":"Panorama Sociodemogr\u00e1fico de Yucat\u00e1n.","year":"2020"},{"key":"b12","series-title":"J Clin Microbiol","first-page":"2172","article-title":"Development of an internally controlled real-time reverse transcriptase PCR assay for pan-dengue virus detection and comparison of four molecular dengue virus detection assays","volume":"51","author":"Waggoner","year":"2013"},{"key":"b13","series-title":"J Med Virol","first-page":"1681","article-title":"Development of multiplex real-time reverse-transcriptase polymerase chain reaction assay for simultaneous detection of Zika, dengue, yellow fever, and chikungunya viruses in a single tube","volume":"90","author":"Wu","year":"2018"},{"key":"b14","series-title":"Diagn Microbiol Infect Dis","first-page":"114894","article-title":"Real-time RT-PCR for the detection and quantitation of oropuche virus","volume":"96","author":"Rojas","year":"2020"},{"key":"b15","series-title":"Am J Trop Med Hyg","first-page":"422","article-title":"Isolation of eastern equine encephalitis virus and West Nile virus from crows during increased arbovirus surveillance in Connecticut, 2000","volume":"66","author":"Beckwith","year":"2002"},{"key":"b16","series-title":"J Virol Methods","first-page":"93","article-title":"Detection of Zika virus by SYBR green one-step real-time RT-PCR","volume":"236","author":"Xu","year":"2016"},{"key":"b17","series-title":"Emerg Infect Dis","first-page":"237","article-title":"Spotted fever group and typhus group rickettsioses in humans, South Korea","volume":"11","author":"Choi","year":"2005"},{"key":"b18","series-title":"Microorganisms","first-page":"674","article-title":"The presence of a virulent clone of Leptospira interrogans serovar canicola in confirmed cases of asymptomatic dog carriers in Mexico","volume":"12","author":"Carmona Gasca","year":"2024"},{"key":"b19","series-title":"Pathogens","first-page":"3","article-title":"Clinical manifestations in a fatal case of probable Rickettsia and Leptospira coinfection in Yucatan, Mexico","volume":"10","author":"Dzul-Rosado","year":"2021"},{"key":"b20","series-title":"PLoS Negl Trop Dis","first-page":"e0007205","article-title":"A simple score to predict severe leptospirosis","volume":"13","author":"Smith","year":"2019"},{"key":"b21","series-title":"Diagnostics","first-page":"1455","article-title":"Diagnosis of human leptospirosis: Comparison of microscopic agglutination test with recombinant LigA\/B antigen-based in-house IgM dot ELISA dipstick test and latex agglutination test using Bayesian latent class model and MAT as gold standard","volume":"12","author":"Behera","year":"2022"},{"key":"b22","article-title":"RStudio: Integrated Development Environment for R","year":"2025"},{"key":"b23","series-title":"Am J Trop Med Hyg","first-page":"940","article-title":"Dengue virus-infected Aedes aegypti in the home environment","volume":"79","author":"Garcia-Rejon","year":"2008"},{"key":"b24","series-title":"Emerg Infect Dis","first-page":"1804","article-title":"Chikungunya virus in febrile humans and Aedes aegypti mosquitoes, Yucatan, Mexico","volume":"22","author":"Cigarroa-Toledo","year":"2016"},{"key":"b25","series-title":"Front Vet Sci","first-page":"1057686","article-title":"Molecular survey of Zika virus in the animal-human interface in traditional farming","volume":"9","author":"Lopez-Apodaca","year":"2022"},{"key":"b26","series-title":"Parasite Epidemiol Control","first-page":"e00088","article-title":"Preliminary epidemiological findings of Leishmania infection in the municipality of Tinum, Yucatan State, Mexico","volume":"4","author":"Lor\u00eda-Cervera","year":"2019"},{"key":"b27","series-title":"Zoonoses Public Health","first-page":"382","article-title":"Molecular confirmation of Rickettsia parkeri in humans from Southern Mexico","volume":"69","author":"Torres-Castro","year":"2022"},{"key":"b28","series-title":"Emerg Infect Dis","first-page":"1665","article-title":"Human rickettsialpox, 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practices","volume":"5","author":"Ruiz","year":"2010"},{"key":"b38","series-title":"Front Public Heal","first-page":"1176730","article-title":"Prevalence and impacts of self-medication in a disadvantaged setting: The importance of multi-dimensional health interventions","volume":"11","author":"Nguyen","year":"2023"},{"key":"b39","series-title":"Pharmacy","first-page":"183","article-title":"Patterns of drug utilization and self-medication practices: A cross sectional study","volume":"11","author":"Al-Omrani","year":"2023"},{"key":"b40","series-title":"Front Public Heal","first-page":"1184882","article-title":"A systematic review of self-medication practice during the COVID-19 pandemic: Implications for pharmacy practice in supporting public health measures","volume":"11","author":"Zheng","year":"2023"},{"key":"b41","series-title":"Travel Med Infect Dis","first-page":"102132","article-title":"Characteristics of patients coinfected with Severe Acute Respiratory Syndrome Coronavirus 2 and dengue virus, Lambayeque, Peru, May \u2013 August 2020: A retrospective analysis","volume":"43","author":"Mej\u00eda-Parra","year":"2021"},{"key":"b42","series-title":"Rev Inst Med Trop Sao Paulo","first-page":"e23","article-title":"Pathology and pathogenesis of human leptospirosis: A commented review","volume":"60","author":"De Brito","year":"2018"},{"key":"b43","series-title":"Rev Panam Salud Publica","first-page":"e126","article-title":"Prevalence of human leptospirosis in the Americas: A systematic review and meta-analysis","volume":"47","author":"Browne","year":"2023"},{"key":"b44","series-title":"Rev Salud Publica (Bogota)","first-page":"1","article-title":"Epidemiologic behavior of leptospirosis in M\u00e9xico during the period 2013\u20132019","volume":"22","author":"Yescas-Ben\u00edtez","year":"2020"},{"key":"b45","series-title":"J Zoonotic Dis","first-page":"1","article-title":"Leptospira spp. in cats from tropical Mexico","volume":"4","author":"Ortega-Pacheco","year":"2020"},{"key":"b46","series-title":"Vet Med Sci","first-page":"40","article-title":"Serological survey of Leptospira interrogans, Toxoplasma gondii and Trypanosoma cruzi in free roaming domestic dogs and cats from a marginated rural area of Yucatan Mexico","volume":"3","author":"Ortega-Pacheco","year":"2017"},{"key":"b47","series-title":"BMC Infect Dis","first-page":"186","article-title":"Leptospirosis in an asplenic patient -case report","volume":"20","author":"Garc\u00eda-M\u00e9ndez","year":"2020"},{"key":"b48","series-title":"Anthrozoos","first-page":"261","article-title":"A survey of dog populations in Urban and rural areas of Yucatan, Mexico","volume":"20","author":"Ortega-Pacheco","year":"2007"},{"key":"b49","series-title":"Rev Peru Med Exp Salud Publica","first-page":"434","article-title":"Diagnostic performance of the rapid test for the detection of NS1 antigen and IgM and IgG anti-antibodies against dengue virus","volume":"39","author":"Valdivia-Conroy","year":"2022"},{"key":"b50","series-title":"J Microbiol Immunol Infect","first-page":"358","article-title":"Laboratory diagnostics of dengue fever: An emphasis on the role of commercial dengue virus nonstructural protein 1 antigen rapid test","volume":"46","author":"Huang","year":"2013"},{"key":"b51","series-title":"PLoS Negl Trop Dis","first-page":"e3171","article-title":"Evaluation of commercially available diagnostic tests for the detection of dengue virus NS1 antigen and anti-dengue virus IgM antibody","volume":"8","author":"Hunsperger","year":"2014"},{"key":"b52","series-title":"Cochrane Database Syst Rev","first-page":"CD013705","article-title":"Rapid, point-of-care antigen tests for diagnosis of SARS-CoV-2 infection","volume":"7","author":"Dinnes","year":"2022"},{"key":"b53","series-title":"Organ Mund la Salud","first-page":"1","article-title":"Leptospirosis Humana. 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