{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T05:57:07Z","timestamp":1780725427008,"version":"3.54.1"},"reference-count":20,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,3]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>Zika virus (ZIKV) infection is a mosquito-borne disease produced by a virus of the Flaviviridae family. It can either be asymptomatic or cause mild febrile illness similar to dengue fever. This study collected 188 serum samples from acute febrile patients in Kota Kinabalu and Lahad Datu, Sabah, Malaysia. The ZIKV genome was detected in 13 (6.9%) patients, and among these, dengue virus (DENV) was detected by quantitative reverse transcription polymerase chain reaction in 6 (3.2%) patients. Thirty-seven patients (19.7%) tested positive for IgM against ZIKV, and 11 patients (5.9%) showed positive neutralization against ZIKV. The positive rate included 7 (3.7%) individuals with coinfection of ZIKV\u2013DENV, 12 (6.4%) individuals with confirmed ZIKV, and 3 (1.6%) individuals with probable ZIKV. Our study concludes that ZIKV infection and DENV\u2013ZIKV coinfection were detected among febrile patients in Kota Kinabalu, Sabah during 2019\u20132020. Therefore, a serosurveillance system is essential to determine the circulation of ZIKV in this area.<\/jats:p>","DOI":"10.4269\/ajtmh.25-0066","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T19:17:29Z","timestamp":1760037449000},"page":"1380-1384","source":"Crossref","is-referenced-by-count":1,"title":["Molecular and Serological Detection of Zika Virus and Zika\u2013Dengue Virus Coinfections in Febrile Patients in Sabah, Malaysia, 2019\u20132020"],"prefix":"10.4269","volume":"113","author":[{"given":"Mya Myat","family":"Ngwe Tun","sequence":"first","affiliation":[{"name":"Department of Tropical Viral Vaccine Development, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan;"},{"name":"Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan;"},{"name":"Center for Vaccines and Therapeutic Antibodies for Emerging Infectious Diseases, Shimane University, Izumo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khine Mya","family":"Nwe","sequence":"additional","affiliation":[{"name":"Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jecelyn Leaslie","family":"John","sequence":"additional","affiliation":[{"name":"Borneo Medical and Health Research Centre, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Malaysia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurine","family":"Mumo","sequence":"additional","affiliation":[{"name":"Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Marsudi","family":"Manah","sequence":"additional","affiliation":[{"name":"Sabah State Health Department, Kota Kinabalu, Malaysia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Takamatsu","sequence":"additional","affiliation":[{"name":"Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Urano","sequence":"additional","affiliation":[{"name":"Center for Vaccines and Therapeutic Antibodies for Emerging Infectious Diseases, Shimane University, Izumo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouichi","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Tropical Viral Vaccine Development, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan;"},{"name":"Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan;"},{"name":"Center for Vaccines and Therapeutic Antibodies for Emerging Infectious Diseases, Shimane University, Izumo, Japan;"},{"name":"Sabah State Health Department, Kota Kinabalu, Malaysia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamruddin","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Borneo Medical and Health Research Centre, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Malaysia;"},{"name":"DEJIMA Infectious Diseases Research Alliance, Nagasaki University, Nagasaki, Japan;"},{"name":"Department of Pathology and Microbiology, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Pathogens","first-page":"74","article-title":"Arboviral disease outbreaks in the Pacific Islands countries and areas, 2014 to 2020. 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