{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T15:11:18Z","timestamp":1780499478829,"version":"3.54.1"},"reference-count":158,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,3]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>\n                    Malaria is a major health concern worldwide, with an estimated 282 million infections and 610,000 deaths in 2024.\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    parasites, spread by female\n                    <jats:italic>Anopheles<\/jats:italic>\n                    mosquitoes, are the cause. Several interventions, such as indoor residual spraying, insecticide-treated bed nets, and antimalarial drugs, have reduced transmission; however, challenges such as insecticide resistance, environmental concerns, and climate change have led to the exploration of alternative approaches. To address these limitations, biological control, which involves the use of natural organisms and biological agents to target mosquito vectors, is increasingly accepted as a viable solution. This method involves viruses, fungi, microbial pathogens, natural predators, alkaloids, essential oils, and plants with larvicidal properties. In addition, genetic techniques such as the sterile insect technique and genetically modified mosquitoes offer new approaches to managing mosquito populations. Additionally, entomopathogenic fungi are of particular interest because they can infect and kill mosquito vectors. In the present narrative review, an overview of existing biological approaches and current research progress that may enhance intervention strategies for sustainable malaria control and eventual eradication is presented.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.25-0084","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T17:11:15Z","timestamp":1775581875000},"page":"1013-1021","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the Scope and Status of Biological Interventions in Malaria Control"],"prefix":"10.4269","volume":"114","author":[{"given":"Sushma","family":"Kumari","sequence":"first","affiliation":[{"name":"Indian Council of Medical Research, National Institute of Malaria Research, Field Unit, Bengaluru, India;"},{"name":"Academy of Scientific and Innovative Research, Ghaziabad, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renuka","family":"Siddaramegowda","sequence":"additional","affiliation":[{"name":"Central Research Laboratory, MAHER, Meenakshi Medical College Hospital and Research Institute, Kanchipuram, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmita","family":"Beeranthbail","sequence":"additional","affiliation":[{"name":"Manipal Institute of Virology, Manipal Academy of Higher Education, Manipal, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopal","family":"Shankar","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research, National Institute of Malaria Research, Field Unit, Bengaluru, India;"},{"name":"Academy of Scientific and Innovative Research, Ghaziabad, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mithun","family":"Kumar","sequence":"additional","affiliation":[{"name":"Indian Institute of Public Health, Gandhinagar, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Sinha","sequence":"additional","affiliation":[{"name":"Model Rural Health Research Unit, Angara, Ranchi, India;"},{"name":"Indian Council of Medical Research, National Institute of Malaria Research, Field Unit, Ranchi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupkumar","family":"Anvikar","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research, National Institute of Malaria Research, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vani H.","family":"Chalageri","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research, National Institute of Malaria Research, Field Unit, Bengaluru, India;"},{"name":"Academy of Scientific and Innovative Research, Ghaziabad, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen Kumar","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Academy of Scientific and Innovative Research, Ghaziabad, India;"},{"name":"Indian Council of Medical Research, National Institute of Malaria Research, Field Unit, Ranchi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrinivasa B.","family":"Marinaik","sequence":"additional","affiliation":[{"name":"Indian Council of Medical Research, National Institute of Malaria Research, Field Unit, Bengaluru, India;"},{"name":"Academy of Scientific and Innovative Research, Ghaziabad, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","article-title":"World Malaria Report 2025.","year":"2025"},{"key":"b2","series-title":"Sci Rep","first-page":"2561","article-title":"Adult mosquito predation and potential impact on the sterile insect technique","author":"Bimbil\u00e9 Somda","year":"2022"},{"key":"b3","series-title":"J Insect 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