{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T01:35:24Z","timestamp":1782869724551,"version":"3.54.5"},"reference-count":24,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,5]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>\n                    This study presents a rare case of rhabdomyolysis caused by\n                    <jats:italic>Orthobunyavirus oropoucheense<\/jats:italic>\n                    in a 21-year-old male patient in the Amazon region. The diagnosis was confirmed by the reverse transcription polymerase chain reaction test. Neutropenia, thrombocytopenia, and hepatitis were also identified by laboratory tests, demonstrating the clinical relevance as they are alterations with potential severity. The patient\u2019s good recovery is noteworthy, with only simple analgesia and intravenous hydration. The case highlights the need for better clarification regarding the pathophysiology of this distinct arbovirus.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.25-0107","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T17:44:33Z","timestamp":1755193473000},"page":"1109-1112","source":"Crossref","is-referenced-by-count":2,"title":["Rhabdomyolysis and Hepatitis Associated with Oropouche Fever: Brazil"],"prefix":"10.4269","volume":"113","author":[{"given":"Kalyne Gabrielle","family":"Caetano Ferreira","sequence":"first","affiliation":[{"name":"Hospital Adventista de Manaus, Manaus, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Hugo","family":"Abdalla Santos","sequence":"additional","affiliation":[{"name":"Hospital Adventista de Manaus, Manaus, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geovana","family":"Ribeiro Pinheiro","sequence":"additional","affiliation":[{"name":"Hospital Adventista de Manaus, Manaus, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligia","family":"Fernandes Abdalla","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Amazonas, Manaus, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Carneiro dos Santos","sequence":"additional","affiliation":[{"name":"Hospital Adventista de Manaus, Manaus, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","article-title":"Virus Taxonomy: 2023 Release.","year":"2025"},{"key":"b2","series-title":"Am J Trop Med Hyg","first-page":"1019","article-title":"Oropouche virus: Clinical, epidemiological, and molecular aspects of a neglected Orthobunyavirus.","volume":"96","author":"Travassos da Rosa","year":"2017"},{"key":"b3","doi-asserted-by":"crossref","DOI":"10.1101\/2024.07.23.24310415","article-title":"Emergence of a Novel Reassortant Oropouche Virus Drives Persistent Outbreaks in the Brazilian Amazon Region from 2022 to 2024.","author":"Naveca","year":"2024"},{"key":"b4","series-title":"Textbook of Pediatric Infectious Diseases","first-page":"2418","author":"Pinheiro","year":"2004"},{"key":"b5","series-title":"J Spec Publ Health Service","first-page":"15","article-title":"Oropouche virus epidemic in Bel\u00e9m. (Originally published as a Preliminary Note.)","volume":"12","author":"Pinheiro","year":"1962"},{"key":"b6","series-title":"Rev Virol Trop","first-page":"305","article-title":"Transmission forms of Oropouche fever","volume":"38","author":"Silva","year":"2022"},{"key":"b7","series-title":"J Clin Microbiol","first-page":"1232","article-title":"Detection of Oropouche virus and its association with fever: A study in the Amazon region of Brazil","volume":"52","author":"Souza","year":"2014"},{"key":"b8","series-title":"Viruses","first-page":"175","article-title":"Oropouche fever: A review","volume":"10","author":"Sakkas","year":"2018"},{"key":"b9","series-title":"J Clin Pathol","first-page":"99","article-title":"Rhabdomyolysis in viral infections: A rare complication","volume":"70","author":"Pradip","year":"2017"},{"key":"b10","series-title":"N Engl J Med","first-page":"62","article-title":"Rhabdomyolysis and acute kidney injury","volume":"361","author":"Bosch","year":"2009"},{"key":"b11","series-title":"Mem Inst Oswaldo Cruz","first-page":"510","article-title":"Multiplexed reverse transcription real-time polymerase chain reaction for simultaneous detection of Mayaro, Oropouche, and Oropouche-like viruses","volume":"112","author":"Naveca","year":"2017"},{"key":"b12","series-title":"Rev Bras Epidemiol","first-page":"45","article-title":"Epidemiological history of Oropouche fever in Brazil","volume":"24","author":"Souza","year":"2021"},{"key":"b13","article-title":"Minist\u00e9rio da Sa\u00fade Promotes Webinar on Oropouche Fever.","year":"2025"},{"key":"b14","series-title":"SAJES \u2013 J of Health of AJES","first-page":"11","article-title":"Hematological alterations found in dengue, Zika, and Chikungunya arboviruses","volume":"6","author":"Matos","year":"2020"},{"key":"b15","series-title":"Emerg Infect Dis","first-page":"2370","article-title":"Fatal Oropouche virus infections in nonendemic region, Brazil, 2024","volume":"30","author":"Bandeira","year":"2024"},{"key":"b16","series-title":"J Clin Virol.","article-title":"Hematological changes in patients with dengue virus infection: A prospective study","author":"Kalimuddin","year":"2019"},{"key":"b17","series-title":"Viruses","first-page":"3827","article-title":"Spread of Oropouche virus into the central nervous system in mouse","volume":"6","author":"Santos","year":"2014"},{"key":"b18","series-title":"Factors Associated with Death Due to Dengue in the Federal District, Brazil, from 2007 to 2015: A Hospital-Based Case-Control Study","author":"Janssen","year":"2017"},{"key":"b19","series-title":"Rev Med Suisse","first-page":"2272","article-title":"Rhabdomyolysis: Early management","volume":"16","author":"Dall\u2019Aglio","year":"2020"},{"key":"b20","series-title":"Crit Care","first-page":"158","article-title":"Bench-to-bedside review: Rhabdomyolysis\u2014An overview for clinicians","volume":"9","author":"Huerta-Alard\u00edn","year":"2005"},{"key":"b21","series-title":"Neth J Med","first-page":"78","article-title":"Dengue shock syndrome and rhabdomyolysis","volume":"65","author":"Karakus","year":"2007"},{"key":"b22","article-title":"Clinical Manifestations and Diagnosis of Rhabdomyolysis.","author":"Miller","year":"2021"},{"key":"b23","article-title":"Overview of Viral Myositis.","author":"Salman Bhai","year":"2024"},{"key":"b24","article-title":"Emerging Viruses.","author":"Hughes","year":"2025"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/113\/5\/article-p1109.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/113\/5\/article-p1109.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/113\/5\/article-p1109.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T14:23:49Z","timestamp":1762352629000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/113\/5\/article-p1109.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,5]]},"references-count":24,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.25-0107","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,5]]}}}