{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T14:02:24Z","timestamp":1764770544937,"version":"3.46.0"},"reference-count":13,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,3]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>\n                    Individuals undergoing cancer treatment represent a vulnerable group either residing in or traveling to dengue endemic regions. Their immunosuppressed state may impair viral clearance, potentially exacerbating disease progression. Additionally, delayed diagnosis may occur because of atypical or masked clinical presentations. In 2024, Brazil faced an unprecedented number of dengue infections. We performed a retrospective observational study conducted at a Brazilian cancer center, an outpatient and inpatient facility, located in S\u00e3o Paulo to evaluate clinical and characteristics of patients with dengue and prior diagnosis of cancer, identify risk factors associated with hospitalization, and determine risk factors associated with in-hospital death. Univariate analyses were performed using the Fisher test or the \u03c7\n                    <jats:sup>2<\/jats:sup>\n                    test, and logistic regression was conducted for the multivariate analysis. A total of 150 patients with diagnoses of dengue and cancer were included in the study. Ninety-eight patients (65.3%) had active cancer or were undergoing oncological treatment. Sixty-nine patients (46%) required hospitalization, with an average length of stay of 9.8 days. Thirteen patients (8.7%) were admitted to the intensive care unit, and five patients (3.3%) died of dengue-related complications. Arterial hypertension (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.001) and elevated liver enzymes (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.004) remained independent risk factors for hospitalization. Multivariate logistic regression did not identify statistically significant predictors for mortality. The high rate of hospitalization may reflect the impact of cancer physiopathology and chemotherapy. Preventive measures, such as early vaccination before starting chemotherapy, should be advised.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.25-0157","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T13:43:08Z","timestamp":1760449388000},"page":"1375-1379","source":"Crossref","is-referenced-by-count":0,"title":["Hospitalization and Mortality in Cancer Patients with Dengue Fever: A Cohort Study from a Brazilian Cancer Center"],"prefix":"10.4269","volume":"113","author":[{"given":"Diego","family":"Feriani","sequence":"first","affiliation":[{"name":"A. C. Camargo Cancer Center, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Paulo","family":"Telles","sequence":"additional","affiliation":[{"name":"A. C. Camargo Cancer Center, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thawani","family":"Andrade de Lima","sequence":"additional","affiliation":[{"name":"A. C. Camargo Cancer Center, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Paula Romero","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"A. C. Camargo Cancer Center, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseanne Lopes","family":"Lima","sequence":"additional","affiliation":[{"name":"A. C. Camargo Cancer Center, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo Reghini","family":"da Silva","sequence":"additional","affiliation":[{"name":"A. C. Camargo Cancer Center, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana","family":"Canteras","sequence":"additional","affiliation":[{"name":"A. C. Camargo Cancer Center, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika Yuki Mogami","family":"Bomfim","sequence":"additional","affiliation":[{"name":"Instituto Em\u00edlio Ribas de Infectologia, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan Leonardo Avelino","family":"Fran\u00e7a e Silva","sequence":"additional","affiliation":[{"name":"A. C. Camargo Cancer Center, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Am J Trop Med Hyg","first-page":"1544","article-title":"A population-based cohort study on chronic comorbidity risk factors for adverse dengue outcomes","volume":"105","author":"Lien","year":"2021"},{"key":"b2","series-title":"Int J Infect Dis","first-page":"107272","article-title":"Dengue fever in immunocompromised patients: A systematic review and meta-analysis","volume":"149","author":"Sohail","year":"2024"},{"key":"b3","series-title":"Lancet","first-page":"311","article-title":"Dengue: The threat to health now and in the future","volume":"404","year":"2024"},{"year":"2024","key":"b4","article-title":"Boletim epidemiol\u00f3gico. Monitoramento das arboviroses e balan\u00e7o de encerramento do Comit\u00ea de Opera\u00e7\u00f5es de Emerg\u00eancia (COE) Dengue e outras Arboviroses 2024"},{"year":"2009","key":"b5","article-title":"Dengue Guidelines, for Diagnosis, Treatment, Prevention and Control"},{"key":"b6","series-title":"BMJ","first-page":"m4087","article-title":"Mortality due to cancer treatment delay: Systematic review and meta-analysis","volume":"371","author":"Hanna","year":"2020"},{"key":"b7","series-title":"Lancet Glob Health","first-page":"e257","article-title":"Long-term efficacy and safety of a tetravalent dengue vaccine (TAK-003): 4\u00b75-year results from a phase 3, randomised, double-blind, placebo-controlled trial","volume":"12","author":"Tricou","year":"2024"},{"key":"b8","series-title":"N Engl J Med","first-page":"2009","article-title":"Efficacy of a tetravalent dengue vaccine in healthy children and adolescents","volume":"381","author":"Biswal","year":"2019"},{"key":"b9","series-title":"N Engl J Med","first-page":"397","article-title":"Live, attenuated, tetravalent butantan-dengue vaccine in children and adults","volume":"390","author":"Kall\u00e1s","year":"2024"},{"key":"b10","series-title":"Int J Infect Dis","first-page":"107192","article-title":"Dengue outbreaks in Brazil and Latin America: The new and continuing challenges","volume":"147","author":"Sansone","year":"2024"},{"key":"b11","series-title":"Am J Trop Med Hyg","first-page":"670","article-title":"Determinants of mortality from severe dengue in Brazil: A population-based case-control study","volume":"88","author":"Moraes","year":"2013"},{"key":"b12","series-title":"Am J Trop Med Hyg","first-page":"102","article-title":"Mortality among hospitalized dengue patients with comorbidities in Mexico, Brazil, and Colombia","volume":"105","author":"Macias","year":"2021"},{"key":"b13","series-title":"Pathogens","first-page":"202","article-title":"Resurgence of Dengue virus serotype 3 in Minas Gerais, Brazil: A case report","volume":"13","author":"Adelino","year":"2024"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/113\/6\/article-p1375.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/113\/6\/article-p1375.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/113\/6\/article-p1375.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T13:33:00Z","timestamp":1764768780000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/113\/6\/article-p1375.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,3]]},"references-count":13,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.25-0157","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"type":"print","value":"0002-9637"},{"type":"electronic","value":"1476-1645"}],"subject":[],"published":{"date-parts":[[2025,12,3]]}}}