{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T22:33:59Z","timestamp":1775601239954,"version":"3.50.1"},"reference-count":17,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>There are limited data on vector-borne diseases from the Ecuadorian Amazon, particularly among marginalized Indigenous populations. From a survey of Shuar communities in Ecuador, we measured IgG antibodies to <jats:italic>Trypanosoma cruzi<\/jats:italic>, dengue virus, and <jats:italic>Leishmania<\/jats:italic> spp. The prevalence of IgG antibodies was 7.4% for <jats:italic>T. cruzi<\/jats:italic>, 21.3% for dengue, and 96.8% for <jats:italic>Leishmania<\/jats:italic> spp. There was an increase in the risk of dengue infections with increasing age (per year; adjusted odds ratio [adj. OR]: 1.03, 95% CI: 1.01\u20131.05, <jats:italic>P<\/jats:italic> = 0.001) and among females (adj. OR: 2.17, 95% CI: 1.03\u20134.57, <jats:italic>P<\/jats:italic> = 0.041). There was an increase in <jats:italic>T. cruzi<\/jats:italic> anti-Tc24 IgG antibody levels with greater age (Spearman <jats:italic>r<\/jats:italic> = 0.553, <jats:italic>P<\/jats:italic> = 0.05). This study showed a high prevalence or exposure to Chagas disease, dengue, and <jats:italic>Leishmania<\/jats:italic> spp. There remains an unmet need for surveillance to monitor the transmission of Chagas and other vector-borne diseases and their associated morbidity in marginalized communities in the Ecuadorian Amazon.<\/jats:p>","DOI":"10.4269\/ajtmh.25-0200","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T13:41:01Z","timestamp":1754574061000},"page":"806-808","source":"Crossref","is-referenced-by-count":1,"title":["Chagas and Vector-Borne Disease Exposures in an Indigenous Community in the Ecuadorian Amazon: A Retrospective Study"],"prefix":"10.4269","volume":"113","author":[{"given":"Rojelio","family":"Mejia","sequence":"first","affiliation":[{"name":"Pediatrics\u2013Tropical Medicine, Baylor College of Medicine, Houston, Texas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Zhan","sequence":"additional","affiliation":[{"name":"Pediatrics\u2013Tropical Medicine, Baylor College of Medicine, Houston, Texas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nestor L.","family":"Uzcategui","sequence":"additional","affiliation":[{"name":"Pediatrics\u2013Tropical Medicine, Baylor College of Medicine, Houston, Texas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Lopez","sequence":"additional","affiliation":[{"name":"School of Medicine, Universidad Internacional del Ecuador, Quito, Ecuador;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Cooper","sequence":"additional","affiliation":[{"name":"School of Medicine, Universidad Internacional del Ecuador, Quito, Ecuador;"},{"name":"Institute of Infection and Immunity, City St. George\u2019s University of London, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Romero-Sandoval","sequence":"additional","affiliation":[{"name":"School of Medicine, Universidad Internacional del Ecuador, Quito, Ecuador;"},{"name":"International Network Grups de Recerca d\u2019Am\u00e8rica i \u00c0frica Llatines, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Lancet","first-page":"65","article-title":"Indigenous health part 1: Determinants and disease patterns","volume":"374","author":"Gracey","year":"2009"},{"key":"b2","series-title":"Am J Trop Med Hyg","first-page":"45","article-title":"High rates of exposures to waterborne pathogens in Indigenous communities in the Amazon region of Ecuador","volume":"101","author":"Romero-Sandoval","year":"2019"},{"key":"b3","series-title":"BMJ Open","first-page":"e013626","article-title":"Soil transmitted helminthiasis in Indigenous groups. 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