{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T14:02:08Z","timestamp":1764770528386,"version":"3.46.0"},"reference-count":14,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,3]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>\n                    Malaria predisposes to anemia in endemic areas, and this effect is compounded by other factors, such as malnutrition, HIV-1 infection, and intestinal helminth infestation. An association with human parvovirus B19 (B19V), with its high infectivity and seroprevalence, is also increasingly recognized. A 22-year-old gentleman, a native of West Bengal, India, was diagnosed with complicated falciparum malaria and treated with intravenous artesunate followed by artemether-lumefantrine. However, despite clearance of parasitemia, he developed a persistent hypoproliferative anemia with no evidence of hemolysis and positive antinuclear antibodies. Bone marrow examination showed markedly decreased erythroid cells with giant pronormoblasts typical of pure red cell aplasia, and B19V quantitative polymerase chain reaction testing showed 2.1 \u00d7 10\n                    <jats:sup>3<\/jats:sup>\n                    international units\/mL. He recovered completely after treatment with intravenous immunoglobulin and a tapering course of prednisone. Similar coinfections are uncommon, and infection-related autoimmunity and dyserythropoiesis are features of both malaria and B19V infection. This case highlights that acute B19V coinfection should be considered in malaria patients with persistent anemia despite parasitological clearance.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.25-0223","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T16:52:54Z","timestamp":1761151974000},"page":"1276-1278","source":"Crossref","is-referenced-by-count":0,"title":["Transient Pure Red Cell Aplasia in a Case of Plasmodium falciparum and Parvovirus B19 Coinfection"],"prefix":"10.4269","volume":"113","author":[{"given":"Christy Varghese","family":"John","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Institute of Postgraduate Medical Education and Research, Kolkata, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayan","family":"Basu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Institute of Postgraduate Medical Education and Research, Kolkata, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debdas","family":"Bose","sequence":"additional","affiliation":[{"name":"Institute of Haematology and Transfusion Medicine, Medical College Kolkata, Kolkata, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yogiraj","family":"Ray","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Institute of Postgraduate Medical Education and Research, Kolkata, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"year":"2024","article-title":"World Malaria Report 2024.","key":"b1"},{"key":"b2","series-title":"Malar J","first-page":"371","article-title":"Anaemia and malaria","volume":"17","author":"White","year":"2018"},{"key":"b3","series-title":"Sci Rep","first-page":"15695","article-title":"A cross-sectional study on risk factors for infection with parvovirus B19 and the association with anaemia in a febrile paediatric population in Ghana","volume":"10","author":"Herr","year":"2020"},{"key":"b4","series-title":"Clin Microbiol Rev","first-page":"43","article-title":"Human parvoviruses","volume":"30","author":"Qiu","year":"2017"},{"key":"b5","series-title":"Blood","first-page":"1381","article-title":"Plasmodium falciparum sexual parasites develop in human erythroblasts and affect erythropoiesis","volume":"136","author":"Neveu","year":"2020"},{"key":"b6","series-title":"Front Cell Infect Microbiol","first-page":"262","article-title":"Autoantibodies and malaria: Where we stand? Insights into pathogenesis and protection","volume":"10","author":"Mour\u00e3o","year":"2020"},{"key":"b7","series-title":"Blood","first-page":"167","article-title":"Postartesunate delayed hemolysis is a predictable event related to the lifesaving effect of artemisinins","volume":"124","author":"Jaur\u00e9guiberry","year":"2014"},{"key":"b8","series-title":"J Clin Pathol","first-page":"279","article-title":"The role of parvovirus B19 in the pathogenesis of autoimmunity and autoimmune disease","volume":"69","author":"Kerr","year":"2016"},{"key":"b9","series-title":"Acta Trop","first-page":"107542","article-title":"Human parvovirus B19 infection in a Plasmodium vivax endemic area on the Brazil\u2013French Guiana border","volume":"263","author":"Motta","year":"2025"},{"key":"b10","series-title":"J Clin Microbiol","first-page":"947","article-title":"Identification of past and recent parvovirus B19 infection in immunocompetent individuals by quantitative PCR and enzyme immunoassays: A dual-laboratory study","volume":"52","author":"Maple","year":"2014"},{"key":"b11","series-title":"Clin Infect Dis","first-page":"1449","article-title":"Acute parvovirus B19 infection and anemia during Plasmodium falciparum malaria","volume":"35","author":"Scarlata","year":"2002"},{"key":"b12","series-title":"Haematologica","first-page":"ECR41","article-title":"Parvovirus B19 co-infection with falciparum malaria: A cause of severe anemia","volume":"90","author":"Gupta","year":"2005"},{"key":"b13","series-title":"J Travel Med","first-page":"taac042","article-title":"Parvovirus B19-associated transient aplastic crisis following P. falciparum malaria and post-artesunate delayed haemolysis in a returning traveller","volume":"29","author":"Huits","year":"2022"},{"key":"b14","series-title":"Clin Infect Dis","first-page":"968","article-title":"Intravenous immunoglobulin therapy for pure red cell aplasia related to human parvovirus B19 infection: A retrospective study of 10 patients and review of the literature","volume":"56","author":"Crabol","year":"2013"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/113\/6\/article-p1276.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/113\/6\/article-p1276.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/113\/6\/article-p1276.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T13:32:19Z","timestamp":1764768739000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/113\/6\/article-p1276.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,3]]},"references-count":14,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.25-0223","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"type":"print","value":"0002-9637"},{"type":"electronic","value":"1476-1645"}],"subject":[],"published":{"date-parts":[[2025,12,3]]}}}