{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:19:37Z","timestamp":1786580377903,"version":"build-2736575974"},"reference-count":38,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,7]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>\n                    Soil-transmitted helminths (STHs) remain a major public health concern, especially in low- and middle-income countries. Although\n                    <jats:italic>Ascaris lumbricoides<\/jats:italic>\n                    ,\n                    <jats:italic>Trichuris trichiura<\/jats:italic>\n                    , and hookworms (\n                    <jats:italic>Ancylostoma duodenale<\/jats:italic>\n                    and\n                    <jats:italic>Necator americanus<\/jats:italic>\n                    ) are commonly identified in humans, emerging evidence using molecular diagnostics capable of differentiating morphologically similar ova suggests zoonotic drivers of transmission, particularly in areas with close human\u2013animal interaction. This pilot study investigated human and animal STH infections across nine villages of Meghalaya in the northeastern region of India, using quantitative polymerase chain reaction with species-specific primers. The estimated STH prevalence was 23.3% (95% CI: 17.9\u201329.9%). Zoonotic potential was evident, with\n                    <jats:italic>Ancylostoma ceylanicum<\/jats:italic>\n                    detected in humans (2.8%), and\n                    <jats:italic>Ascaris<\/jats:italic>\n                    spp. and\n                    <jats:italic>Necator americanus<\/jats:italic>\n                    detected in pigs (64.5% and 3.2%, respectively) and goats (15.2% and 3.0%, respectively). To meet World Health Organization\u2019s target of eliminating STH morbidity by 2030, endemic regions may need to adopt an integrated One Health approach.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.25-0401","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:21:23Z","timestamp":1762874483000},"page":"138-141","source":"Crossref","is-referenced-by-count":3,"title":["Zoonotic Transmission of Soil-Transmitted Helminths in a Setting with Close Human\u2013Animal Interaction: A Cross-Sectional Pilot Study from Meghalaya, India"],"prefix":"10.4269","volume":"114","author":[{"given":"Uniqueky Gratis","family":"Mawrie","sequence":"first","affiliation":[{"name":"Indian Institute of Public Health, Shillong, India;"},{"name":"Department of Disease Control, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malathi","family":"Manuel","sequence":"additional","affiliation":[{"name":"The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter John","family":"Marbaniang","sequence":"additional","affiliation":[{"name":"Indian Institute of Public Health, Shillong, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Innangkyntiew Lyngdoh","family":"Sangriang","sequence":"additional","affiliation":[{"name":"Indian Institute of Public Health, Shillong, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selvi","family":"Laxmanan","sequence":"additional","affiliation":[{"name":"The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sitara Swarna Rao","family":"Ajjampur","sequence":"additional","affiliation":[{"name":"The Wellcome Trust Research Laboratory, Division of Gastrointestinal Sciences, Christian Medical College, Vellore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Indian Institute of Public Health, Shillong, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Infect Dis Poverty","first-page":"77","article-title":"Global burden of soil-transmitted helminth infections, 1990\u20132021","volume":"13","author":"Chen","year":"2024"},{"key":"b2","series-title":"PLoS Negl Trop Dis","first-page":"e0007580","article-title":"Risk profiling of soil-transmitted helminth infection and estimated number of infected people in South Asia: A systematic review and Bayesian geostatistical Analysis","volume":"13","author":"Lai","year":"2019"},{"key":"b3","series-title":"PLOS Glob Public Health","first-page":"e0004614","article-title":"The occurrence of cross-host species soil-transmitted helminth infections in humans and domestic\/livestock animals: A systematic review","volume":"5","author":"Mawrie","year":"2025"},{"key":"b4","article-title":"Ending the Neglect to Attain the Sustainable Development Goals: A Road Map for Neglected Tropical Diseases 2021\u20132030.","year":"2021"},{"key":"b5","article-title":"National Family Health Survey (NFHS-5), 2019\u201321.","year":"2021"},{"key":"b6","series-title":"Int J Sci Res","first-page":"75","article-title":"Prevalence mapping of soil transmitted helminths in north eastern states of India\u2014First report","volume":"8","author":"Ganguly","year":"2019"},{"key":"b7","series-title":"PLoS Negl Trop Dis","first-page":"e0012760","article-title":"Development and validation of a high-throughput qPCR platform for the detection of soil-transmitted helminth infections","volume":"19","author":"Pilotte","year":"2025"},{"key":"b8","series-title":"Am J Trop Med Hyg","first-page":"1041","article-title":"A novel, multi-parallel, real-time polymerase chain reaction approach for eight gastrointestinal parasites provides improved diagnostic capabilities to resource-limited at-risk populations","volume":"88","author":"Mejia","year":"2013"},{"key":"b9","series-title":"PLoS Negl Trop Dis","first-page":"e0004578.10","article-title":"Improved PCR-based detection of soil transmitted helminth infections using a next-generation sequencing approach to assay design","volume":"10","author":"Pilotte","year":"2016"},{"key":"b10","series-title":"PLoS Negl Trop Dis","first-page":"e0005734","article-title":"A novel, species-specific, real-time PCR assay for the detection of the emerging zoonotic parasite Ancylostoma ceylanicum in human stool","volume":"11","author":"Papaiakovou","year":"2017"},{"key":"b11","series-title":"PLoS Negl Trop Dis","first-page":"e0007593","article-title":"Targeting a highly repeated germline DNA sequence for improved real-time PCR-based detection of Ascaris infection in human stool","volume":"13","author":"Pilotte","year":"2019"},{"key":"b12","series-title":"J Stat Soft","first-page":"1","article-title":"Analysis of complex survey samples","volume":"9","author":"Lumley","year":"2004"},{"key":"b13","article-title":"Evidence-Based Impact of National Deworming Day in India.","year":"2020"},{"key":"b14","series-title":"Trends Parasitol","first-page":"844","article-title":"Ancylostoma ceylanicum.","volume":"37","author":"Colella","year":"2021"},{"key":"b15","article-title":"Census.","year":"2023"},{"key":"b16","series-title":"PLoS Negl Trop Dis","first-page":"e0004891","article-title":"Molecular identification of hookworm isolates in humans, dogs and soil in a tribal area in Tamil Nadu, India","volume":"10","author":"George","year":"2016"},{"key":"b17","series-title":"Vet Parasitol","first-page":"233","article-title":"The prevalence and distribution of gastrointestinal parasites of stray and refuge dogs in four locations in India","volume":"205","author":"Traub","year":"2014"},{"key":"b18","series-title":"Zoonoses Public Health","first-page":"474","article-title":"Dogs and pigs are transport hosts of Necator americanus: Molecular evidence for a zoonotic mechanism of human hookworm transmission in Ghana","volume":"67","author":"Boyko","year":"2020"},{"key":"b19","series-title":"J Infect Dis","first-page":"1355","article-title":"Ascaris lumbricoides or Ascaris suum: What\u2019s in a name?","volume":"213","author":"Betson","year":"2016"},{"key":"b1","series-title":"Infect Dis Poverty","first-page":"77","article-title":"Global burden of soil-transmitted helminth infections, 1990\u20132021","volume":"13","author":"Chen","year":"2024"},{"key":"b2","series-title":"PLoS Negl Trop Dis","first-page":"e0007580","article-title":"Risk profiling of soil-transmitted 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tribal area in Tamil Nadu, India","volume":"10","author":"George","year":"2016"},{"key":"b17","series-title":"Vet Parasitol","first-page":"233","article-title":"The prevalence and distribution of gastrointestinal parasites of stray and refuge dogs in four locations in India","volume":"205","author":"Traub","year":"2014"},{"key":"b18","series-title":"Zoonoses Public Health","first-page":"474","article-title":"Dogs and pigs are transport hosts of Necator americanus: Molecular evidence for a zoonotic mechanism of human hookworm transmission in Ghana","volume":"67","author":"Boyko","year":"2020"},{"key":"b19","series-title":"J Infect Dis","first-page":"1355","article-title":"Ascaris lumbricoides or Ascaris suum: What\u2019s in a name?","volume":"213","author":"Betson","year":"2016"}],"container-title":["The American Journal of Tropical Medicine and 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