{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:05:14Z","timestamp":1789430714646,"version":"build-2803163510"},"reference-count":56,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,6]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>\n                    Scabies, a contagious parasitic skin infestation, is a significant global public health concern and a neglected tropical disease (NTD). Understanding its long-term epidemiological trends, diagnostic accuracy, and treatment outcomes is crucial for effective control. This study aimed to analyze a decade of scabies infection data from Zhanjiang, China. We retrospectively collected clinical data from 2,428 outpatients diagnosed with confirmed scabies at the Affiliated Hospital of Guangdong Medical University (2014\u20132024). Diagnostic methods (dermoscopy and microscopy) were compared. Treatment efficacy of 10% sulfur ointment was assessed via 10-day follow-up in 100 positive patients. Males comprised 78% of cases (male:female ratio 3.5:1), with school-age children (\u22653 and &lt;18 years) accounting for 51.2%. Among 865 compared patients (2021\u20132024), the diagnostic sensitivity of dermoscopy was significantly higher than that of microscopy (99.8% versus 46.8%,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.001). The 10-day follow-up indicated a low 13% cure rate with sulfur ointment. Scabies epidemiology in Zhanjiang, particularly among school-age children, shows a clear upward trend and significant resurgence, aligning with China\u2019s COVID-19 prevention policies. Our findings support dermoscopy\u2019s diagnostic superiority in comparison with microscopic examination. Low cure rates with sulfur ointment necessitate reassessment of current treatment approaches and implementation of effective public health interventions, such as mass drug administration (e.g., ivermectin), to control this NTD.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.25-0478","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T18:49:22Z","timestamp":1775155762000},"page":"937-943","source":"Crossref","is-referenced-by-count":1,"title":["Ten-Year Trends and Clinical Implications of Scabies Infection: A Single-Center Retrospective Analysis in Zhanjiang, China"],"prefix":"10.4269","volume":"114","author":[{"given":"Ping-Ping","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-Di","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Mei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tu-Ming","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","article-title":"Scabies: Resources for Health Professionals.","year":"2024"},{"key":"b2","series-title":"PLoS Negl Trop Dis","first-page":"e0006996","article-title":"Exploration of a simplified clinical examination for scabies to support public health decision-making","volume":"12","author":"Marks","year":"2018"},{"key":"b3","series-title":"Trop Med Int Health","first-page":"1006","article-title":"Prevalence and determinants of scabies: A global systematic review and meta-analysis","volume":"29","author":"Gupta","year":"2024"},{"key":"b4","series-title":"Lancet Infect Dis","first-page":"1247","article-title":"The global burden of scabies: A cross-sectional analysis from the Global Burden of Disease Study 2015","volume":"17","author":"Karimkhani","year":"2017"},{"key":"b5","series-title":"Turkiye Parazitol Derg","first-page":"235","article-title":"The scabies epidemic during the Covid-19 pandemic","volume":"47","author":"Etiz","year":"2023"},{"key":"b6","series-title":"J Infect Dev Ctries","first-page":"S337","article-title":"Impact of COVID-19 lockdowns and refugee influx on scabies presentations to dermatology outpatient clinics in turkey","volume":"18","author":"\u00d6zta\u015f Kara","year":"2024"},{"key":"b7","series-title":"BMC Infect Dis","first-page":"481","article-title":"Status of the scabies outbreak before, during and after the Covid-19 pandemic: A single-center hospital-based retrospective evaluation","volume":"25","author":"Ayhan","year":"2025"},{"key":"b8","series-title":"Life (Basel)","first-page":"1598","article-title":"Increased scabies incidence at the beginning of the 21st century: What do reports from Europe and the world show?","volume":"12","author":"A\u017edaji\u0107","year":"2022"},{"key":"b9","series-title":"Br J Dermatol","first-page":"808","article-title":"The 2020 International Alliance for the Control of Scabies Consensus Criteria for the Diagnosis of Scabies","volume":"183","author":"Engelman","year":"2020"},{"key":"b10","series-title":"Clinical Dermatology","first-page":"693","author":"Zhao","year":"2017"},{"key":"b11","series-title":"Br J Dermatol","first-page":"888","article-title":"Risk factors for treatment failure in scabies: A cohort study","volume":"180","author":"Aussy","year":"2019"},{"key":"b12","series-title":"Arch Dermatol","first-page":"468","article-title":"Comparison of dermoscopy, skin scraping, and the adhesive tape test for the diagnosis of scabies in a resource-poor setting","volume":"147","author":"Walter","year":"2011"},{"key":"b13","series-title":"J Am Acad Dermatol","first-page":"53","article-title":"Accuracy of standard dermoscopy for diagnosing scabies","volume":"56","author":"Dupuy","year":"2007"},{"key":"b14","series-title":"Clin Microbiol Rev","first-page":"268","article-title":"Problems in diagnosing scabies, a global disease in human and animal populations","volume":"20","author":"Walton","year":"2007"},{"key":"b15","series-title":"J Dermatolog Treat","first-page":"774","article-title":"Loss of efficacy of topical 5% permethrin for treating scabies: An Austrian single-center study","volume":"33","author":"Meyersburg","year":"2022"},{"key":"b16","series-title":"J Eur Acad Dermatol Venereol","first-page":"160","article-title":"Comparison of topical benzyl benzoate vs. oral ivermectin in treating scabies: A randomized study","volume":"37","author":"Meyersburg","year":"2023"},{"key":"b17","series-title":"J Drugs Dermatol","first-page":"357","article-title":"Treatment of scabies using 8% and 10% topical sulfur ointment in different regimens of application","volume":"11","author":"Sharquie","year":"2012"},{"key":"b18","series-title":"Int J Dermatol","first-page":"e19","article-title":"Sulfur 17% ointment for topical treatment of scabies in children: Old but gold","volume":"63","author":"Baffa","year":"2024"},{"key":"b19","series-title":"Ann Parasitol","first-page":"79","article-title":"The efficacy of oral ivermectin vs. sulfur 10% ointment for the treatment of scabies","volume":"61","author":"Alipour","year":"2015"},{"key":"b20","series-title":"J Eur Acad Dermatol Venereol","first-page":"1248","article-title":"European guideline for the management of scabies","volume":"31","author":"Salavastru","year":"2017"},{"key":"b21","series-title":"Int J STD AIDS","first-page":"516","article-title":"British Association for Sexual Health and HIV National Guideline on the Management of Scabies in adults 2025","volume":"36","author":"Morris","year":"2025"},{"key":"b22","series-title":"Chin J Dermatol","first-page":"1","article-title":"Chinese expert consensus on the diagnosis and treatment of scabies (2026 edition)","volume":"59","year":"2026"},{"key":"b23","series-title":"J Cutan Med Surg","first-page":"299","article-title":"Comparative trial of oral ivermectin versus sulfur 8% ointment for the treatment of scabies","volume":"17","author":"Goldust","year":"2013"},{"key":"b24","series-title":"N Engl J Med","first-page":"1018","article-title":"Control of neglected tropical diseases","volume":"357","author":"Hotez","year":"2007"},{"key":"b25","series-title":"N Engl J Med","first-page":"2305","article-title":"Mass drug administration for scabies control in a population with endemic disease","volume":"373","author":"Romani","year":"2015"},{"key":"b26","series-title":"Lancet Reg Health West Pac","first-page":"100433","article-title":"Prevention of bacterial complications of scabies using mass drug administration: A population-based, before-after trial in Fiji, 2018\u20132020","volume":"22","author":"Thean","year":"2022"},{"key":"b27","series-title":"J Infect Dev Ctries","first-page":"78S","article-title":"Does mass drug administration for community-based scabies control works? The experience in Ethiopia","volume":"14","author":"Enbiale","year":"2020"},{"key":"b28","series-title":"N Engl J Med","first-page":"717","article-title":"Permethrin and ivermectin for scabies","volume":"362","author":"Currie","year":"2010"},{"key":"b1","article-title":"Scabies: Resources for Health Professionals.","year":"2024"},{"key":"b2","series-title":"PLoS Negl Trop Dis","first-page":"e0006996","article-title":"Exploration of a simplified clinical examination for scabies to support public health decision-making","volume":"12","author":"Marks","year":"2018"},{"key":"b3","series-title":"Trop Med Int Health","first-page":"1006","article-title":"Prevalence and determinants of scabies: A global systematic review and meta-analysis","volume":"29","author":"Gupta","year":"2024"},{"key":"b4","series-title":"Lancet Infect Dis","first-page":"1247","article-title":"The global burden of scabies: A cross-sectional analysis from the Global Burden of Disease Study 2015","volume":"17","author":"Karimkhani","year":"2017"},{"key":"b5","series-title":"Turkiye Parazitol Derg","first-page":"235","article-title":"The scabies epidemic during the Covid-19 pandemic","volume":"47","author":"Etiz","year":"2023"},{"key":"b6","series-title":"J Infect Dev Ctries","first-page":"S337","article-title":"Impact of COVID-19 lockdowns and refugee influx on scabies presentations to dermatology outpatient clinics in turkey","volume":"18","author":"\u00d6zta\u015f Kara","year":"2024"},{"key":"b7","series-title":"BMC Infect Dis","first-page":"481","article-title":"Status of the scabies outbreak before, during and after the Covid-19 pandemic: A single-center hospital-based retrospective evaluation","volume":"25","author":"Ayhan","year":"2025"},{"key":"b8","series-title":"Life (Basel)","first-page":"1598","article-title":"Increased scabies incidence at the beginning of the 21st century: What do reports from Europe and the world show?","volume":"12","author":"A\u017edaji\u0107","year":"2022"},{"key":"b9","series-title":"Br J Dermatol","first-page":"808","article-title":"The 2020 International Alliance for the Control of Scabies Consensus Criteria for the Diagnosis of Scabies","volume":"183","author":"Engelman","year":"2020"},{"key":"b10","series-title":"Clinical Dermatology","first-page":"693","author":"Zhao","year":"2017"},{"key":"b11","series-title":"Br J Dermatol","first-page":"888","article-title":"Risk factors for treatment failure in scabies: A cohort study","volume":"180","author":"Aussy","year":"2019"},{"key":"b12","series-title":"Arch Dermatol","first-page":"468","article-title":"Comparison of dermoscopy, skin scraping, and the adhesive tape test for the diagnosis of scabies in a resource-poor setting","volume":"147","author":"Walter","year":"2011"},{"key":"b13","series-title":"J Am Acad Dermatol","first-page":"53","article-title":"Accuracy of standard dermoscopy for diagnosing scabies","volume":"56","author":"Dupuy","year":"2007"},{"key":"b14","series-title":"Clin Microbiol Rev","first-page":"268","article-title":"Problems in diagnosing scabies, a global disease in human and animal populations","volume":"20","author":"Walton","year":"2007"},{"key":"b15","series-title":"J Dermatolog Treat","first-page":"774","article-title":"Loss of efficacy of topical 5% permethrin for treating scabies: An Austrian single-center study","volume":"33","author":"Meyersburg","year":"2022"},{"key":"b16","series-title":"J Eur Acad Dermatol Venereol","first-page":"160","article-title":"Comparison of topical benzyl benzoate vs. oral ivermectin in treating scabies: A randomized study","volume":"37","author":"Meyersburg","year":"2023"},{"key":"b17","series-title":"J Drugs Dermatol","first-page":"357","article-title":"Treatment of scabies using 8% and 10% topical sulfur ointment in different regimens of application","volume":"11","author":"Sharquie","year":"2012"},{"key":"b18","series-title":"Int J Dermatol","first-page":"e19","article-title":"Sulfur 17% ointment for topical treatment of scabies in children: Old but gold","volume":"63","author":"Baffa","year":"2024"},{"key":"b19","series-title":"Ann Parasitol","first-page":"79","article-title":"The efficacy of oral ivermectin vs. sulfur 10% ointment for the treatment of scabies","volume":"61","author":"Alipour","year":"2015"},{"key":"b20","series-title":"J Eur Acad Dermatol Venereol","first-page":"1248","article-title":"European guideline for the management of scabies","volume":"31","author":"Salavastru","year":"2017"},{"key":"b21","series-title":"Int J STD AIDS","first-page":"516","article-title":"British Association for Sexual Health and HIV National Guideline on the Management of Scabies in adults 2025","volume":"36","author":"Morris","year":"2025"},{"key":"b22","series-title":"Chin J Dermatol","first-page":"1","article-title":"Chinese expert consensus on the diagnosis and treatment of scabies (2026 edition)","volume":"59","year":"2026"},{"key":"b23","series-title":"J Cutan Med Surg","first-page":"299","article-title":"Comparative trial of oral ivermectin versus sulfur 8% ointment for the treatment of scabies","volume":"17","author":"Goldust","year":"2013"},{"key":"b24","series-title":"N Engl J Med","first-page":"1018","article-title":"Control of neglected tropical diseases","volume":"357","author":"Hotez","year":"2007"},{"key":"b25","series-title":"N Engl J Med","first-page":"2305","article-title":"Mass drug administration for scabies control in a population with endemic disease","volume":"373","author":"Romani","year":"2015"},{"key":"b26","series-title":"Lancet Reg Health West Pac","first-page":"100433","article-title":"Prevention of bacterial complications of scabies using mass drug administration: A population-based, before-after trial in Fiji, 2018\u20132020","volume":"22","author":"Thean","year":"2022"},{"key":"b27","series-title":"J Infect Dev Ctries","first-page":"78S","article-title":"Does mass drug administration for community-based scabies control works? The experience in Ethiopia","volume":"14","author":"Enbiale","year":"2020"},{"key":"b28","series-title":"N Engl J Med","first-page":"717","article-title":"Permethrin and ivermectin for scabies","volume":"362","author":"Currie","year":"2010"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/114\/5\/article-p937.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/114\/5\/article-p937.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/114\/5\/article-p937.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T15:37:27Z","timestamp":1778081847000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/114\/5\/article-p937.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,6]]},"references-count":56,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.25-0478","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,6]]}}}