{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T20:01:10Z","timestamp":1772740870116,"version":"3.50.1"},"reference-count":126,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,4]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>Lasting sequelae are identified in 50% of child survivors of cerebral malaria (CM). Rehabilitation options in malaria-endemic regions are scarce and largely focused on physical deficits, leaving children without support for cognitive recovery. Effective and accessible interventions are vital for improving outcomes. Furthermore, the assessment of brain function and recovery after CM is dependent on behavior-based tests that are time-consuming and require substantial training to administer. Objective, easy-to-use alternatives may be impactful. Children aged 3\u201312 years who had survived CM were recruited. Participants underwent a 6-month in-home, tablet-based neurorehabilitation program called Dino Island (DI). Participants also underwent serial assessments of brain health that were conducted by measuring event-related potentials (ERPs) using the Brain Vital Signs system. The feasibility, fidelity, acceptability, appropriateness, and affordability of the interventions were evaluated through interviews with the study nurses and the participants\u2019 families. Both programs were feasible and easy to implement. Acceptability was demonstrated by low attrition rates (5%) and positive family ratings (100%). Appropriateness for DI was confirmed by parent reports of positive behavioral changes in their children (60%). For Brain Vital Signs, appropriateness was confirmed by adequate data acquisition for most participants. Finally, positive indicators of affordability from a healthcare perspective were identified. Neurorehabilitation using a home tablet-based program and objective brain health assessment using ERPs was feasible, well accepted, and appropriate in child CM survivors in sub-Saharan Africa. Further development and research into the program\u2019s ability to improve and measure cognitive recovery is justified.<\/jats:p>","DOI":"10.4269\/ajtmh.25-0492","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T14:28:05Z","timestamp":1765895285000},"page":"458-465","source":"Crossref","is-referenced-by-count":0,"title":["A Pilot Feasibility Study of a Home Tablet-Based Neurorehabilitation Program and Serial Brain Vital Sign Monitoring for Survivors of Pediatric Cerebral Malaria"],"prefix":"10.4269","volume":"114","author":[{"given":"Sarah J.","family":"Macoun","sequence":"first","affiliation":[{"name":"Child Neuropsychology Lab, University of Victoria, Victoria, British Columbia, Canada;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica M.","family":"Silverman","sequence":"additional","affiliation":[{"name":"Child Neuropsychology Lab, University of Victoria, Victoria, British Columbia, Canada;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe R.","family":"Brunet","sequence":"additional","affiliation":[{"name":"Child Neuropsychology Lab, University of Victoria, Victoria, British Columbia, Canada;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica M.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Child Neuropsychology Lab, University of Victoria, Victoria, British Columbia, Canada;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edith","family":"Kafoteka","sequence":"additional","affiliation":[{"name":"The Blantyre Malaria Project, Queen Elizabeth Central Hospital, Blantyre, Malawi;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thereza","family":"Ziba","sequence":"additional","affiliation":[{"name":"The Blantyre Malaria Project, Queen Elizabeth Central Hospital, Blantyre, Malawi;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric D.","family":"Kirby","sequence":"additional","affiliation":[{"name":"Centre for Neurology Studies, HealthTech Connex, Metro Vancouver, British Columbia, Canada;"},{"name":"BrainNET, Faculty of Applied Sciences, Simon Fraser University, Metro Vancouver, British Columbia, Canada;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Ighalo","sequence":"additional","affiliation":[{"name":"BrainNET, Faculty of Applied Sciences, Simon Fraser University, Metro Vancouver, British Columbia, Canada;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan C. N.","family":"D\u2019Arcy","sequence":"additional","affiliation":[{"name":"Centre for Neurology Studies, HealthTech Connex, Metro Vancouver, British Columbia, Canada;"},{"name":"BrainNET, Faculty of Applied Sciences, Simon Fraser University, Metro Vancouver, British Columbia, Canada;"},{"name":"DM Centre for Brain Health, Radiology, University of British Columbia, Metro Vancouver, British Columbia, Canada;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Nationwide Children\u2019s Hospital\/The Ohio State University, Columbus, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Lancet Microbe","first-page":"e214","article-title":"The 2023 WHO world malaria report","volume":"5","author":"Venkatesan","year":"2024"},{"key":"b2","series-title":"BMC Med","first-page":"52","article-title":"What causes severe malaria and its complications in children? 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